Transcription factor II F

Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1][2][3]

general transcription factor IIF, polypeptide 1, 74kDa
Identifiers
SymbolGTF2F1
Alt. symbolsTFIIF, BTF4, RAP74
NCBI gene2962
HGNC4652
OMIM189968
RefSeqNM_002096
UniProtP35269
Other data
LocusChr. 19 p13.3
Search for
StructuresSwiss-model
DomainsInterPro
general transcription factor IIF, polypeptide 2, 30kDa
Identifiers
SymbolGTF2F2
Alt. symbolsTFIIF, BTF4, RAP30
NCBI gene2963
HGNC4653
OMIM189969
RefSeqNM_004128
UniProtP13984
Other data
LocusChr. 13 q14
Search for
StructuresSwiss-model
DomainsInterPro
general transcription factor IIF, polypeptide 2-like
Identifiers
SymbolGTF2F2L
Alt. symbolsTFIIF
NCBI gene2964
HGNC4654
RefSeqNG_003013
Other data
LocusChr. 4 q31.22

TFIIF is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes.[4][5][6]

TFIIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB.

See also

References
  1. Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X.
  2. Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
  3. Kim TK, Lagrange T, Wang YH, Griffith JD, Reinberg D, Ebright RH (1997). "Trajectory of DNA in the RNA polymerase II transcription preinitiation complex". Proc Natl Acad Sci USA. 94 (23): 12268–73. Bibcode:1997PNAS...9412268K. doi:10.1073/pnas.94.23.12268. PMC 24903. PMID 9356438.
  4. Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode:1992Natur.355..464F. doi:10.1038/355464a0. PMID 1734284. S2CID 1241044.
  5. Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. doi:10.1093/hmg/3.1.61. PMID 8162052.
  6. Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH (1995). "Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens". Cytogenet. Cell Genet. 69 (1–2): 75–80. doi:10.1159/000133942. PMID 7835093.


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