ZEB1

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[5][6][7]

ZEB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDsOMIM: 189909 MGI: 1344313 HomoloGene: 31779 GeneCards: ZEB1
Orthologs
SpeciesHumanMouse
Entrez

6935

21417

Ensembl

ENSG00000148516

ENSMUSG00000024238

UniProt

P37275

Q64318

RefSeq (mRNA)

NM_011546
NM_001360981
NM_001360982

RefSeq (protein)

NP_035676
NP_001347910
NP_001347911

Location (UCSC)Chr 10: 31.32 – 31.53 MbChr 18: 5.59 – 5.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[7][6] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[8] The structure of the homeodomain is shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas[9] A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[10] Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.[11]

References
  1. GRCh38: Ensembl release 89: ENSG00000148516 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024238 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
  6. Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. Bibcode:1991Sci...254.1791W. doi:10.1126/science.1840704. PMID 1840704.
  7. "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
  8. Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.
  9. Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R (March 2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells". Oncogene. 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.
  10. Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.
  11. Lu J, Fei F, Wu C, Mei J, Xu J, Lu P (September 2022). "ZEB1: Catalyst of immune escape during tumor metastasis". Biomed Pharmacother. 153: 113490. doi:10.1016/j.biopha.2022.113490. PMID 36076506.

Further reading


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