Rickettsia conorii

Rickettsia conorii
"Rickettsia conorii" observed in Vero cells (red rods; magnification ×1,000)
Rickettsia conorii observed in Vero cells (red rods; magnification ×1,000)[1]
Scientific classification edit
Domain: Bacteria
Phylum: Pseudomonadota
Class: Alphaproteobacteria
Order: Rickettsiales
Family: Rickettsiaceae
Genus: Rickettsia
Species group: Spotted fever group
Species:
R. conorii
Binomial name
Rickettsia conorii
Brumpt 1932[2]

Rickettsia conorii is a Gram-negative, obligate intracellular bacterium of the genus Rickettsia that causes human disease called boutonneuse fever, Mediterranean spotted fever, Israeli tick typhus, Astrakhan spotted fever, Kenya tick typhus, Indian tick typhus, or other names that designate the locality of occurrence while having distinct clinical features.[3][4] It is a member of the spotted fever group and the most geographically dispersed species in the group, recognized in most of the regions bordering on the Mediterranean Sea and Black Sea, Israel, Kenya, and other parts of North, Central, and South Africa, and India.[3] The prevailing vector is the brown dog tick, Rhipicephalus sanguineus. The bacterium was isolated by Emile Brumpt in 1932[5] and named after A. Conor, who in collaboration with A. Bruch, provided the first description of boutonneuse fever in Tunisia in 1910.[6]

The genome of the bacterium has been sequenced and four subspecies have been identified.[7][8][9][10][11]

Genomes of intracellular or parasitic bacteria undergo massive reduction compared to their free-living relatives. Examples include Rickettsia for alpha proteobacteria, T. whipplei for Actinobacteria, Mycoplasma for Firmicutes (the low G+C content Gram-positive), and Wigglesworthia and Buchnera for gamma proteobacteria.[12]

Some of the largest virions like Megavirus chilensis, Pandoravirus, Pithovirus and mimivirus are comparable in size to miniature bacteria like T. whipplei and Rickettsia conorii.

Gimenez staining: smears of infected Rhipicephalus sanguineus salivary glands (with Rickettsia conorii )

References

  1. ↑ Rovery C, Brouqui P, Raoult D (2008). "Questions on Mediterranean Spotted Fever a Century after Its Discovery". Emerg Infect Dis. 14 (9): 1360–1367. doi:10.3201/eid1409.071133. PMC 2603122. PMID 18760001.
  2. ↑ Skerman, VBD; McGowan, V; Sneath, PHA, eds. (1989). Approved Lists of Bacterial Names (amended ed.). Washington, DC: American Society for Microbiology. Archived from the original on 2019-09-15. Retrieved 2022-02-18.
  3. 1 2 Yu, XJ; Walker, DH (2005). "Genus I. Rickettsia da Rocha-Lima 1916, 567AL". In Brenner, DJ; Krieg, NR; Staley, JT; et al. (eds.). Bergey's Manual of Systematic Bacteriology, Volume 2, Part C (2nd ed.). New York: Springer. doi:10.1007/0-387-29298-5_28.
  4. ↑ Parola, P; Paddock, CD; Raoult, D (2005). "Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts". Clin Microbiol Rev. 18 (4): 719–756. doi:10.1128/CMR.18.4.719-756.2005. PMC 1265907. PMID 16223955.
  5. ↑ Brumpt, E (1932). "Longevité du virus de la fièvre boutonneuse (Rickettsia conorii, n. sp.) chez la tique Rhipicephalus sanguineus". C. R. Soc. Biol. 110: 1119–1202.
  6. ↑ Conor, A & A Bruch (1910). "Une fièvre éruptive observée en Tunisie". Bull Soc Pathol Exot Filial. 8: 492–496.
  7. ↑ Zhu Y, Fournier PE, Eremeeva M, Raoult D (2005). "Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conorii". BMC Microbiol. 5: 11. doi:10.1186/1471-2180-5-11. PMC 1079849. PMID 15766388.
  8. ↑ Ogata H, Audic S, Renesto-Audiffren P, et al. (September 2001). "Mechanisms of evolution in Rickettsia conorii and R. prowazekii". Science. 293 (5537): 2093–8. Bibcode:2001Sci...293.2093O. doi:10.1126/science.1061471. PMID 11557893. S2CID 35985908.
  9. ↑ Sentausa E, El Karkouri K, Robert C, Raoult D, Fournier PE (June 2012). "Genome sequence of Rickettsia conorii subsp. indica, the agent of Indian tick typhus". J. Bacteriol. 194 (12): 3288–9. doi:10.1128/JB.00462-12. PMC 3370856. PMID 22628514.
  10. ↑ Sentausa E, El Karkouri K, Robert C, Raoult D, Fournier PE (September 2012). "Genome sequence of Rickettsia conorii subsp. caspia, the agent of Astrakhan fever". J. Bacteriol. 194 (17): 4763–4. doi:10.1128/JB.00992-12. PMC 3415478. PMID 22887666.
  11. ↑ Sentausa E, El Karkouri K, Robert C, Raoult D, Fournier PE (September 2012). "Genome sequence of Rickettsia conorii subsp. israelensis, the agent of Israeli spotted fever". J. Bacteriol. 194 (18): 5130–1. doi:10.1128/JB.01118-12. PMC 3430316. PMID 22933760.
  12. ↑ Raoult, Didier; Ogata, Hiroyuki; Audic, Stéphane; Robert, Catherine; Suhre, Karsten; Drancourt, Michel; Claverie, Jean-Michel (2003). "Tropheryma whipplei Twist: A Human Pathogenic Actinobacteria with a Reduced Genome". Genome Research. 13 (8): 1800–1809. doi:10.1101/gr.1474603. PMC 403771. PMID 12902375. Archived from the original on 2022-04-17. Retrieved 2022-02-18.

Further reading


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