SIB-1553A

SIB-1553A
Names
	Preferred IUPAC name 4-{[2-(1-Methylpyrrolidin-2-yl)ethyl]sulfanyl}phenol
Identifiers
CAS Number	191611-76-4 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL47850;
ChemSpider	4470512;
PubChem CID	5310968;
CompTox Dashboard (EPA)	DTXSID70940803 ;
	InChI InChI=1S/C13H19NOS/c1-14-9-2-3-11(14)8-10-16-13-6-4-12(15)5-7-13/h4-7,11,15H,2-3,8-10H2,1H3 Key: NVZGJSVPOOILDI-UHFFFAOYSA-N; InChI=1/C13H19NOS/c1-14-9-2-3-11(14)8-10-16-13-6-4-12(15)5-7-13/h4-7,11,15H,2-3,8-10H2,1H3 Key: NVZGJSVPOOILDI-UHFFFAOYAV;
	SMILES OC1=CC=C(SCCC2CCCN2C)C=C1;
Properties
Chemical formula	C13H19NOS
Molar mass	237.36 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

SIB-1553A is a nicotinic acetylcholine receptor agonist that is selective for receptors with a β₄ subunit. Administration of SIB-1553A improved memory and attention in a Parkinson's disease model.^[1]

References

↑ Schneider, JS (July 2003). "The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys". Journal of Pharmacology and Experimental Therapeutics. 306 (1): 401–6. doi:10.1124/jpet.103.051912. PMID 12721323. S2CID 7060934.

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[Schneider-1] Schneider, JS (July 2003). "The Subtype-Selective Nicotinic Acetylcholine Receptor Agonist SIB-1553A Improves Both Attention and Memory Components of a Spatial Working Memory Task in Chronic Low Dose 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Monkeys". Journal of Pharmacology and Experimental Therapeutics. 306 (1): 401–6. doi:10.1124/jpet.103.051912. PMID 12721323. S2CID 7060934.

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