INSM1
INSM1 (INSM transcriptional repressor 1) هوَ بروتين يُشَفر بواسطة جين INSM1 في الإنسان.[1][2][3][3]
الوظيفة
المراجع
- "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases"، Biochem J، 397 (1): 169–77، يونيو 2006، doi:10.1042/BJ20051669، PMC 1479746، PMID 16569215.
- "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1"، J Biol Chem، 269 (19): 14170–4، يونيو 1994، PMID 8188699.
- "Entrez Gene: INSM1 insulinoma-associated 1"، مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
- "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs."، J. Biol. Chem.، 267 (21): 15252–7، 1992، PMID 1634555.
- "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1."، Biochem. Biophys. Res. Commun.، 236 (3): 776–81، 1997، doi:10.1006/bbrc.1997.7054، PMID 9245732.
- "The DNA sequence and comparative analysis of human chromosome 20."، Nature، 414 (6866): 865–71، 2002، Bibcode:2001Natur.414..865D، doi:10.1038/414865a، PMID 11780052.
- "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence."، Nucleic Acids Res.، 30 (4): 1038–45، 2002، doi:10.1093/nar/30.4.1038، PMC 100352، PMID 11842116.
- "Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells."، Pancreas، 24 (2): 139–45، 2002، doi:10.1097/00006676-200203000-00004، PMID 11854618.
- "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein."، Genomics، 80 (1): 54–61، 2003، doi:10.1006/geno.2002.6800، PMC 1237014، PMID 12079283.
- "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system."، J. Biol. Chem.، 278 (40): 38991–7، 2003، doi:10.1074/jbc.M306795200، PMC 1236987، PMID 12890672.
- Tao Zhang؛ Breslin MB؛ Lan MS (2009)، "Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest."، J. Biol. Chem.، 284 (9): 5574–81، doi:10.1074/jbc.M808843200، PMC 2645817، PMID 19124461.
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي
بوابة طب
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