PLAG1
PLAG1 (PLAG1 zinc finger) هوَ بروتين يُشَفر بواسطة جين PLAG1 في الإنسان.[1][2]
الوظيفة
المراجع
- "A 2-Mb YAC contig and physical map covering the chromosome 8q12 breakpoint cluster region in pleomorphic adenomas of the salivary glands"، Genomics، 43 (3): 349–58، نوفمبر 1997، doi:10.1006/geno.1997.4819، PMID 9268638.
- "Entrez Gene: PLAG1 pleiomorphic adenoma gene 1"، مؤرشف من الأصل في 08 مارس 2010.
قراءة متعمقة
- "PLAG1, the prototype of the PLAG gene family: versatility in tumour development (review)"، Int. J. Oncol.، 30 (4): 765–74، 2007، doi:10.3892/ijo.30.4.765، PMID 17332914.
- "Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations"، Nat. Genet.، 15 (2): 170–4، 1997، doi:10.1038/ng0297-170، PMID 9020842.
- "The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter"، Oncogene، 16 (11): 1409–16، 1998، doi:10.1038/sj.onc.1201660، PMID 9525740.
- "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins"، J. Biol. Chem.، 273 (36): 23026–32، 1998، doi:10.1074/jbc.273.36.23026، PMID 9722527.
- "Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene"، Cancer Res.، 59 (4): 918–23، 1999، PMID 10029085.
- "PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II"، Cancer Res.، 60 (1): 106–13، 2000، PMID 10646861.
- "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal"، J. Biol. Chem.، 277 (22): 19673–8، 2002، doi:10.1074/jbc.M112112200، PMID 11882654.
- "The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities"، Cancer Res.، 62 (5): 1510–7، 2002، PMID 11888928.
- "Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas"، Int. J. Oncol.، 20 (4): 713–6، 2002، doi:10.3892/ijo.20.4.713، PMID 11894114.
- "Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma"، Genes Chromosomes Cancer، 39 (2): 126–37، 2004، doi:10.1002/gcc.10307، PMID 14695992.
- "Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation"، J. Biol. Chem.، 279 (34): 36121–31، 2004، doi:10.1074/jbc.M401753200، PMID 15208321.
- "Functional proteomics mapping of a human signaling pathway"، Genome Res.، 14 (7): 1324–32، 2004، doi:10.1101/gr.2334104، PMC 442148، PMID 15231748.
- "Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification"، Cancer Genet. Cytogenet.، 152 (2): 124–8، 2004، doi:10.1016/j.cancergencyto.2003.12.001، PMID 15262430.
- "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11"، Blood، 105 (7): 2900–7، 2005، doi:10.1182/blood-2004-09-3630، PMID 15585652.
- "PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement"، Cancer Genet. Cytogenet.، 156 (2): 183–4، 2005، doi:10.1016/j.cancergencyto.2004.04.017، PMID 15642402.
- "PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry"، Mod. Pathol.، 18 (8): 1048–55، 2005، doi:10.1038/modpathol.3800386، PMID 15920557.
- "Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression"، Cancer Res.، 65 (11): 4544–53، 2005، doi:10.1158/0008-5472.CAN-04-4041، PMID 15930271.
- "Wnt pathway is involved in pleomorphic adenomas induced by overexpression of PLAG1 in transgenic mice"، Int. J. Cancer، 118 (3): 643–8، 2006، doi:10.1002/ijc.21400، PMID 16108035.
- بوابة الكيمياء الحيوية
- بوابة طب
- بوابة علم الأحياء الخلوي والجزيئي
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