POLR2K
POLR2K (RNA polymerase II subunit K) هوَ بروتين يُشَفر بواسطة جين POLR2K في الإنسان.[1]
الوظيفة
المراجع
- "Entrez Gene: POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa"، مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
- Jeang KT (1998)، "Tat, Tat-associated kinase, and transcription."، J. Biomed. Sci.، 5 (1): 24–7، doi:10.1007/BF02253352، PMID 9570510.
- "Transcriptional control: Tat cofactors and transcriptional elongation."، Curr. Biol.، 8 (13): R447–9، 1998، doi:10.1016/S0960-9822(98)70289-1، PMID 9651670.
- "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression."، J. Cell. Biochem.، 75 (3): 357–68، 2000، doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K، PMID 10536359.
- "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator."، IUBMB Life، 51 (3): 175–81، 2002، doi:10.1080/152165401753544241، PMID 11547919.
- Howe KJ (2002)، "RNA polymerase II conducts a symphony of pre-mRNA processing activities."، Biochim. Biophys. Acta، 1577 (2): 308–24، doi:10.1016/s0167-4781(02)00460-8، PMID 12213660.
- "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention."، Med Res Rev، 26 (5): 595–625، 2007، doi:10.1002/med.20081، PMID 16838299.
- "Will diverse Tat interactions lead to novel antiretroviral drug targets?"، Current drug targets، 7 (12): 1595–606، 2007، doi:10.2174/138945006779025338، PMID 17168834.
- "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC."، J. Acquir. Immune Defic. Syndr.، 5 (11): 1142–7، 1992، PMID 1403646.
- "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors."، Genes Dev.، 6 (4): 655–66، 1992، doi:10.1101/gad.6.4.655، PMID 1559613.
- "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein."، Nature، 345 (6276): 640–2، 1990، Bibcode:1990Natur.345..640S، doi:10.1038/345640a0، PMID 2190099.
- "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat"، Proc. Natl. Acad. Sci. U.S.A.، 92 (16): 7153–7، 1995، Bibcode:1995PNAS...92.7153W، doi:10.1073/pnas.92.16.7153، PMC 41297، PMID 7638159.
- "Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae"، Mol. Cell. Biol.، 15 (9): 4702–10، 1995، PMC 230713، PMID 7651387.
- "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor"، J. Virol.، 69 (3): 1612–20، 1995، PMC 188757، PMID 7853496.
- "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex"، Proc. Natl. Acad. Sci. U.S.A.، 93 (6): 2505–10، 1996، Bibcode:1996PNAS...93.2505K، doi:10.1073/pnas.93.6.2505، PMC 39827، PMID 8637904.
- "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function"، J. Virol.، 70 (7): 4576–84، 1996، PMC 190394، PMID 8676484.
- "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB"، J. Mol. Biol.، 261 (5): 599–606، 1996، doi:10.1006/jmbi.1996.0485، PMID 8800208.
- "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat"، Science، 274 (5287): 605–10، 1996، Bibcode:1996Sci...274..605Z، doi:10.1126/science.274.5287.605، PMID 8849451.
- "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II"، Proc. Natl. Acad. Sci. U.S.A.، 93 (21): 11575–9، 1996، Bibcode:1996PNAS...9311575O، doi:10.1073/pnas.93.21.11575، PMC 38099، PMID 8876177.
- "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1"، J. Biol. Chem.، 271 (44): 27888–94، 1996، doi:10.1074/jbc.271.44.27888، PMID 8910388.
- "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain"، Nature، 384 (6607): 375–8، 1996، Bibcode:1996Natur.384..375P، doi:10.1038/384375a0، PMID 8934526.
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي
بوابة طب
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