Ethinylestradiol/megestrol acetate

Ethinylestradiol/megestrol acetate (EE/MGA), sold under the brand name Volidan among others, was a combination of ethinylestradiol (EE), an estrogen, and megestrol acetate (MGA), a progestin, which was used as a birth control pill to prevent pregnancy in women.[1][2] It was taken by mouth and contained 50 to 100 μg EE and 1 to 5 mg MGA per tablet.[2][1] MGA-containing birth control pills were withdrawn after reports in the early 1970s of a high incidence of venous thromboembolism in association with the preparations.[3]

Ethinylestradiol/megestrol acetate
Ethinylestradiol
Megestrol acetate
Combination of
EthinylestradiolEstrogen
Megestrol acetateProgestogen; Progestin
Clinical data
Trade namesNuvacon, Volidan
Other namesEE/MGA
Routes of
administration
By mouth
Drug classEstrogen; Progestin; Progestogen
Legal status
Legal status
Identifiers
CAS Number
PubChem CID

See also

References

  1. Lara Marks (2001). Sexual Chemistry: A History of the Contraceptive Pill. Yale University Press. pp. 77–78. ISBN 978-0-300-08943-1.
  2. Mears E (1963). "A new type of oral contraceptive". Br Med J. 1 (5341): 1318–20. doi:10.1136/bmj.1.5341.1318. PMC 2123904. PMID 13934321.
  3. El Makhzangy MN, Wynn V, Lawrence DM (January 1979). "Sex hormone binding globulin capacity as an index of oestrogenicity or androgenicity in women on oral contraceptive steroids". Clinical Endocrinology. 10 (1): 39–45. doi:10.1111/j.1365-2265.1979.tb03031.x. PMID 571314. S2CID 7262495.



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