HLA-B*83

HLA-B*83 (B83) is an HLA-B allele-group composed of a single allele, B*8301. There is no useful serology associated with this allele.[1]

Further information: HLA-serotype tutorial
Illustration of HLA-B with bound peptide
major histocompatibility complex (human), class I, B*83
Alleles B*8301
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B**8301
Locus chr.6 6p21.31

It is found in a single Mbenzele Pygmy tribe of the Central Africa Republic at 1.5%.[2] B*8301 appears to be the result of the replacement of exon 2 from B*4402 with exon 2 from B*5603.[3] (For terminology help see: HLA-serotype tutorial)

Location of Central African Republic
Location of Africa's Pygmy Tribes

References
  1. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. Bruges Armas J, Destro-Bisol G, López-Vazquez A, et al. (2003). "HLA class I variation in the West African Pygmies and their genetic relationship with other African populations". Tissue Antigens. 62 (3): 233–42. doi:10.1034/j.1399-0039.2003.00100.x. PMID 12956877.
  3. Steiner NK, Gans CP, Kosman C, et al. (2001). "New alleles in the B44 family including B*44022, B*44032, B*4411, B*4420, B*4421, B*4424, and B*8301". Tissue Antigens. 57 (4): 376–9. doi:10.1034/j.1399-0039.2001.057004376.x. PMID 11380952.
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