HLA-B18
HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products.[1] (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.
major histocompatibility complex (human), class I, B18 | ||
| Alleles | B*1801 | |
| Alleles | B*1802 | |
| Alleles | B*1803 | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*1801 | |
| EBI-HLA | B*1802 | |
| EBI-HLA | B*1803 | |
| Locus | chr.6 6p21.31 | |
Serotype
B*18:06 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*46:01, B*55:03, and B*73:01.[2]
| B*18 | B18 | Sample | |
| allele | % | % | size (N) |
| 1801 | 96 | 1641 | |
| 1802 | 90 | 31 | |
| 1803 | 83 | 29 |
Allele frequencies
| freq | ||
| ref. | Population | (%) |
| [4] | Italy North pop 1 | 16.7 |
| [4] | Croatia | 11.3 |
| [4] | Georgia Svaneti Svans | 11.3 |
| [4] | Romanian | 11.3 |
| [4] | Portugal South | 11.2 |
| [4] | Singapore Riau Malay | 9.9 |
| [4] | Bulgaria | 9.1 |
| [4] | Israel Arab Druse | 8.5 |
| [4] | Azores Central Islands | 8.0 |
| [4] | Portugal Centre | 8.0 |
| [4] | Finland | 7.8 |
| [4] | Azores Santa Maria and Sao Miguel | 7.7 |
| [4] | Czech Republic | 7.5 |
| [4] | India Jalpaiguri Toto | 7.5 |
| [4] | Iran Baloch | 7.1 |
| [4] | Philippines Ivatan | 7.0 |
| [4] | Thailand | 6.7 |
| [4] | Tunisia | 6.7 |
| [4] | Portugal North | 6.5 |
| [4] | Zimbabwe Harare Shona | 6.4 |
| [4] | Madeira | 6.2 |
| [4] | Mexico Mestizos | 6.1 |
| [4] | Kenya | 5.9 |
| [4] | Belgium | 5.1 |
| [4] | Morocco Nador Metalsa Class I | 5.1 |
| [4] | Singapore Javanese Indonesians | 5.1 |
| [4] | Israel Ashkenazi and Non Ashkenazi Jews | 5.0 |
| [4] | Uganda Kampala | 5.0 |
| [4] | Kenya Nandi | 4.8 |
| [4] | Oman | 4.7 |
| [4] | Georgia Tbilisi Georgians | 4.6 |
| [4] | Bulgaria Gipsy | 4.5 |
| [4] | France South East | 4.3 |
| [4] | Kenya Luo | 4.3 |
| [4] | Ireland South | 4.2 |
| [4] | Russia Arkhangelsk Pomors | 4.0 |
| [4] | Azores Terceira Island | 3.9 |
| [4] | Guinea Bissau | 3.8 |
| [4] | India New Delhi | 3.8 |
| [4] | Spain Eastern Andalusia Gipsy | 3.5 |
| [4] | Australia New South Wales | 3.4 |
| [4] | Georgia Tbilisi Kurds | 3.4 |
| [4] | Zambia Lusaka | 3.4 |
| [4] | Cameroon Yaounde | 2.7 |
| [4] | Senegal Niokholo Mandenka | 2.7 |
| [4] | Cameroon Beti | 2.3 |
| [4] | Ivory Coast Akan Adiopodoume | 2.3 |
| [4] | Sudanese | 2.3 |
| [4] | Saudi Arabia Guraiat and Hail | 2.2 |
| [4] | South African Natal Zulu | 2.0 |
| [4] | Thailand | 2.0 |
| [4] | India Mumbai Marathas | 1.9 |
| [4] | New Caledonia | 1.9 |
| [4] | Papua New Guinea Wanigela | 1.5 |
| [4] | Cameroon Bamileke | 1.3 |
References
- Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.
- derived from IMGT/HLA
- Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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