HLA-B50
HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49.[1] The serotype identifies the more common HLA-B*50 gene products.[2] (For terminology help see: HLA-serotype tutorial)
major histocompatibility complex (human), class I, B50 | ||
| Alleles | B*5001, B*5002, | |
| Structure (See HLA-B) | ||
| Symbol(s) | HLA-B | |
| EBI-HLA | B*5001 | |
| B*5002 | ||
| Locus | chr.6 6p21.31 | |
Serotype
| B*50 | B50 | B21 | Sample |
| allele | % | % | size (N) |
| 5001 | 85 | 3 | 1700 |
The B*5002 by serotype definition is a B45 serotype.[4]
Allele distribution
| freq | ||
| ref. | Population | (%) |
| [5] | Saudi Arabia Guraiat and Hail | 17.3 |
| [5] | Tunisia | 10.0 |
| [5] | Israel Arab Druse | 8.5 |
| [5] | Morocco Nador Metalsa (Berber) | 7.3 |
| [5] | Tunisia Tunis | 6.3 |
| [5] | Israel Ashkenazi and Non Ashkenazi Jews | 5.5 |
| [5] | Azores Terceira Island | 5.1 |
| [5] | Georgia Svaneti Svans | 3.8 |
| [5] | India North Delhi | 3.8 |
| [5] | Italy Bergamo | 3.6 |
| [5] | Georgia Tbilisi Kurds | 3.4 |
| [5] | Italy North (1) | 3.3 |
| [5] | Brazil Belo Horizonte | 3.2 |
| [5] | Madeira | 3.2 |
| [5] | Italy North Pavia | 3.1 |
| [5] | Portugal South | 3.1 |
| [5] | Oman | 3.0 |
| [5] | Georgia Tbilisi Georgians | 2.8 |
| [5] | Bulgaria | 2.7 |
| [5] | Azores Santa Maria and Sao Miguel | 2.6 |
| [5] | Spain Eastern Andalusia Gipsy | 2.5 |
| [5] | Sudanese | 2.5 |
| [5] | Czech Republic | 2.4 |
| [5] | Spain Eastern Andalusia | 2.4 |
| [5] | Spain Mallorca and Menorca | 2.2 |
| [5] | Burkina Faso Fulani | 2.0 |
| [5] | China Inner Mongolia | 2.0 |
| [5] | China North Han | 1.9 |
| [5] | India North Hindus | 1.9 |
| [5] | China Qinghai Hui | 1.8 |
| [5] | Jordan Amman | 1.7 |
| [5] | Russia Tuva (2) | 1.7 |
| [5] | Spain Catalonia Girona | 1.7 |
| [5] | Senegal Niokholo Mandenka | 1.6 |
| [5] | Guinea Bissau | 1.5 |
| [5] | India New Delhi | 1.5 |
| [5] | Croatia | 1.3 |
| [5] | Cuban Mulatto | 1.2 |
| [5] | France South East | 1.2 |
| [5] | Burkina Faso Rimaibe | 1.1 |
| [5] | Mali Bandiagara | 1.1 |
| [5] | Belgium | 1.0 |
| [5] | Ireland Northern | 1.0 |
| [5] | Ireland South | 1.0 |
| [5] | Italy Sardinia pop3 | 1.0 |
| [5] | South Africa Natal Tamil | 1.0 |
| B*5002 | ||
| [5] | Morocco Nador Metalsa (Berber) | 4.3 |
| [5] | Portugal North | 1.1 |
| [5] | Portugal South | 1.0 |
| [5] | Madeira | 0.8 |
| [5] | Tunisia Tunis | 0.6 |
References
- Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
- Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
- derived from IMGT/HLA
- Balas A, Santos S, García-Sánchez F, Lillo R, Merino L, Vicario JL (1998). "Characterization and distribution of HLA-B*5002 in a Spanish population sample". Tissue Antigens. 52 (2): 183–6. doi:10.1111/j.1399-0039.1998.tb02283.x. PMID 9756408.
- Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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