HLA-B62

HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.[1]


HLA-B62 with bound peptide
major histocompatibility complex (human), class I, B62
Alleles	1501, 1504, 1507, 1525
Structure (See HLA-B)
Shared data
Locus	chr.6 6p21.31

B62 is the largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507 B*1525 and B*1533 allele products.

Serotype

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77
recognition of the HLA B*15 gene products[2]
B*15	B15	B62	B63	B70	B71	B72	B75	B76	B77	Sample
allele	%	%	%	%	%	%	%	%	%	size (N)
*1501	2	96								1906
*1504	10	69								29
*1505	18	64								22
*1506		40		20			11			10
*1507		79								101
*1508		20					18			45
*1511	15	27					21			68
*1512	17	18						8		12
*1515	13	49					28			138
*1520		100								5
*1524		44								54
*1525	7	74					8			116
*1527	7	76								76
*1528	14	57					14			7
*1530	17	64								98
*1531		50								12
*1535		79								34
Allele	B15	B62	B63	B70	B71	B72	B75	B76	B77	N
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

**HLA B*1501 frequencies**
		freq
ref.	Population	(%)
[3]	Japan Ainu Hokkaido	29.0
	Chihuahuan Tarahumara	14.8
	Autonomous Tibetans	12.3
	South Korea ( 3)	10.5
	Japan Central	8.7
	Japan pop3	7.5
	USA North American Natives	7.2
	South Dakota Lakota Sioux	7.1
	Shijiazhuang Tianjian Han	7.0
	China Qinghai Hui	6.8
	Croatia	6.7
	Japan pop5	6.5
	Portugal Centre	6.0
	Taiwan Rukai	6.0
	USA Alaska Yupik Natives	5.8
	Australia New South Wales	5.6
	USA European Americans (2)	5.6
	France South East	5.5
	China Beijing	5.3
	Czech Republic	4.7
	Ireland South	4.6
	Mexico Sonora Seri	4.5
	China Inner Mongolia	4.4
	Russia Tuva (2)	4.2
	Singapore Chinese	4.0
	Taiwan Paiwan	3.9
	China North Han	3.8
	Georgia Svaneti Svans	3.8
	Ireland Northern	3.8
	Italy North Pavia	3.7
	Mexico Mestizos	3.7
	Azores Central Islands	3.6
	Madeira	3.5
	Taiwan Minnan pop 1	3.4
	Azores Terceira Island	3.1
	Taiwan Siraya	2.9
	USA Hispanic	2.8
	Taiwan Hakka	2.7
	Taiwan Pazeh	2.7
	China Yunnan Nu	2.6
	Uganda Kampala	2.5
	Argentina Toba Rosario	2.3
	Romanian	2.3
	Hong Kong Chinese	2.2
	India North Hindus	1.9
	New Caledonia	1.9
	Italy South Campania	1.8
	Taiwan Thao	1.7
	India North Delhi	1.6
	China Guangzhou	1.5
	China Guangxi Maonan	1.4
	China Yunnan Lisu	1.4
	Thailand	1.4
	PNG New Britain Rabaul	1.3
	Brazil Belo Horizonte	1.1
	Cameroon Yaounde	1.1
	Portugal North	1.1
	United Arab Emerates	1.1
	Thailand pop3	1.0
	USA African America	1.0
	USA African Americans	1.0
	Indig. Australian Yuendumu	0.8
	PNG Wanigela	0.8
	Mexico Zaptotec Oaxaca	0.7
	Spain Eastern Andalusia	0.6
	South African Natal Zulu	0.5
	Spain E. Andalusia Gipsy	0.5
	Sudanese	0.5
	Taiwan Bunun	0.5

**HLA B*1515 frequencies**
		freq
ref.	Population	(%)
[3]	Mexico Mestizos	2.4
	Mex. Guadalajara Mestizos (2)	1.9
	Argentina Toba Rosario	1.2
	China Guangdong Meizhou Han	1.0
	China North Han	1.0
	Cape Verde NW Islands	0.8
	USA South Texas Hispanics	0.8
	USA San Antonio Caucasians	0.6
	USA Hispanic	0.4
	USA Asian	0.3
	USA North American Natives	0.3
	USA African America	0.2
	Hong Kong Chinese	0.1

**HLA B*1525 frequencies**
		freq
ref.	Population	(%)
[3]	Taiwan Tao	40.0
	Taiwan Thao	11.7
	Taiwan Pazeh	10.9
	China Yunnan Lisu	8.7
	China Yunnan Nu	8.3
	PNG West Schrader Ranges	8.2
	Indig. Australian Groote Eylandt	8.0
	Taiwan Puyuma	7.0
	Taiwan Rukai	7.0
	Taiwan Bunun	6.4
	Indig. Australian Yuendumu	5.7
	Taiwan Siraya	4.9
	Taiwan Tsou	4.9
	Philippines Ivatan	3.0
	Taiwan Atayal	2.8
	Taiwan Ami	2.6
	Thailand	2.5
	China Guangzhou	2.0
	Thailand pop3	2.0
	Hong Kong Chinese	1.9
	PNG Wanigela	1.5
	PNG Wosera	1.5
	Singapore Thai	1.5
	India Andhra Pradesh Golla	1.4
	PNG Eastern Highlands Goroka	1.4
	China South Han	1.1
	China Inner Mongolia	1.0
	India North Hindus	1.0

**HLA B*1507 frequencies**
		freq
ref.	Population	(%)
[3]	Argentina Toba Rosario	8.1
	New Mexico Canoncito Navajo	3.7
	Brazil Terena	2.6
	USA North American Natives	0.8
	Japan Central	0.7
	South Korea pop 3	0.6
	Japan pop3	0.4
	USA Asian	0.4
	Shijiazhuang Tianjian Han	0.3
	USA Caucasian pop2	0.2
	Hong Kong Chinese	0.1
	Ireland Northern	0.1

References

Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
derived from IMGT/HLA
Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)

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[pmid15787720-1] Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.

[2] rived from IMGT/HLA

[pmid12753660-3] Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)