HLA-B8

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products.[1] (For terminology help see: HLA-serotype tutorial) HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

Further information: B8-DR3 in autoimmune diseases
Computer illustration of HLA-B*0801 with EBV peptide in the binding pocket.
B*0801-β2MG with bound peptide1m05​
major histocompatibility complex (human), class I, B8
Alleles B*0801
Structure (See HLA-B)Avail. 3D structures
EBI-HLA B*08011mi5​, 1m05​
1agf​, 1age​
1agd​, 1agc​
1agb​,1a9b​
Symbol(s) HLA-B
Locus chr.6 6p21.31

Serotype
B8 serotype recognition of Some HLA B*08 allele-group gene products[2]
B*08B8 Sample
allele %size (N)
*0801996508
*0804297
Allele links out to IMGT/HLA Databease at EBI

Alleles
HLA B*0801 frequencies
freq
ref.Population(%)
[3]Ireland South18.2
[3]Australia New South Wales17.3
[3]Ireland Northern16.2
[3]Belgium12.6
[3]Oman11.0
[3]Spain Basque Gipuzkoa Province9.1
[3]Finland8.9
[3]France South East8.9
[3]Scotland Orkney8.8
[3]Morocco Nador Metalsa Class I8.7
[3]India New Delhi8.3
[3]Spain Eastern Andalusia Gipsy8.1
[3]Madeira7.8
[3]Guinea Bissau7.7
[3]Iran Baloch7.6
[3]South African Natal Zulu7.5
[3]Brazil Belo Horizonte7.4
[3]Cape Verde Southeastern Islands7.3
[3]Romanian7.3
[3]Saudi Arabia Guraiat and Hail7.1
[3]South Africa Natal Tamil7.1
[3]Georgia Svaneti Svans6.9
[3]India Andhra Pradesh Golla6.7
[3]Portugal North6.5
[3]Azores Santa Maria and Sao Miguel6.4
[3]Uganda Kampala6.2
[3]Cape Verde Northwestern Islands5.6
[3]Cameroon Yaounde5.4
[3]Italy Bergamo5.3
[3]Czech Republic5.2
[3]Cameroon Pygmy Baka5.0
[3]Senegal Niokholo Mandenka4.8
[3]Kenya Nandi4.6
[3]Spain Catalonia Girona4.6
[3]Tunisia4.6
[3]Bulgaria Gipsy4.5
[3]Tunisia Tunis4.5
[3]Brazil4.3
[3]Portugal Centre4.0
[3]Sudanese4.0
[3]Cameroon Sawa3.8
[3]Jordan Amman3.8
[3]Indig. Australian, Cape York Peninsula3.5
[3]Georgia Tbilisi Kurds3.4
[3]Zambia Lusaka3.4
[3]Kenya3.1
[3]Zimbabwe Harare Shona3.1
[3]Kenya Luo3.0
[3]Mexico Zaptotec Oaxaca3.0
[3]India North Hindus2.9
[3]Mexico Mestizos2.4
[3]Ivory Coast Akan Adiopodoume2.3
[3]Indig. Australian, Groote Eylandt2.0
[3]Portugal South2.0
[3]Georgia Tbilisi Georgians1.9
[3]Azores Central Islands1.8
[3]Bulgaria1.8
[3]Argentina Toba Rosario1.7
[3]Croatia1.7
[3]India North Delhi1.6
[3]China North Han1.4
[3]Cameroon Beti1.1
[3]Cameroon Bakola Pygmy1.0
[3]India West Coast Parsis1.0
[3]Taiwan Siraya1.0

References
  1. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. derived from IMGT/HLA
  3. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)
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