HLA-B49

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50.[1] The serotype identifies the more common HLA-B*50 gene products.[2] (For terminology help see: HLA-serotype tutorial)

major histocompatibility complex (human), class I, B49
Alleles B*4901, B*4902, B*4903
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*4901
B*4902
B*4903
Locus chr.6 6p21.31

Serotype

B49 and B21 serotype recognition of some more common HLA B*49 alleles[3]
B*49B49 B21Sample
allele % %size (N)
49019413002

Allele distribution

HLA B*4901 frequencies
freq
ref.Population(%)
[4]Portugal North8.7
[4]Spain Basque Gipuzkoa Province6.1
[4]Madeira5.9
[4]Cameroon Yaounde5.4
[4]Morocco Nador Metalsa (Berber)5.1
[4]Kenya Nandi4.6
[4]Sudanese4.3
[4]Portugal South4.1
[4]Tunisia Tunis4.0
[4]India Jalpaiguri Toto3.8
[4]Senegal Niokholo Mandenka3.7
[4]Uganda Kampala3.7
[4]Spain Eastern Andalusia3.5
[4]Tunisia3.5
[4]Georgia Tbilisi Kurds3.4
[4]Spain Catalonia Girona3.4
[4]Italy North (1)3.3
[4]Cameroon Beti3.2
[4]Israel Ashkenazi and Non Ashkenazi Jews3.2
[4]Guinea Bissau3.1
[4]France South East2.7
[4]Israel Arab Druse2.5
[4]Mali Bandiagara2.5
[4]Jordan Amman2.4
[4]Tunisia Ghannouch2.4
[4]Georgia Tbilisi Georgians2.3
[4]Saudi Arabia Guraiat and Hail2.2
[4]Cameroon Bamileke1.9
[4]Czech Republic1.9
[4]Georgia Svaneti Svans1.9
[4]Macedonia (4)1.9
[4]Bulgaria1.8
[4]Romanian1.6
[4]Italy Bergamo1.1
[4]Zambia Lusaka1.1
[4]Belgium1.0
[4]China North Han1.0
[4]India Andhra Pradesh Golla1.0
[4]Ireland Northern1.0
[4]South African Natal Zulu1.0

References

  1. Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
  2. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  3. derived from IMGT/HLA
  4. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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