HLA-B63

HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.[1]

Further information: HLA-serotype tutorial
Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B63
Alleles *1516, *1517
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

B63 is one of many split antigens of the broad antigen, B15. B63 identifies the B*1516 and B*1517 allele products.

Serotype
Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the
HLA B*15 gene products[2]
B*15B15 B62B63 B70B71B72 B75B76B77Sample
allele % % % % % % % % %size (N)
*1516380816
*1517288797
Alleles link-out to IMGT/HLA Databease at EBI

Alleles
HLA B*1516 frequencies
freq
ref.Population(%)
[3]Ivory Coast Akan Adiopodoume4.6
Cameroon Bamileke3.2
USA African Americans (3)1.9
Italy South Campania1.6
United Arab Emerates1.5
Brazil1.4
Azores S. Maria and S. Miguel1.3
Zimbabwe Harare Shona1.3
Cameroon Beti1.1
Cameroon Yaounde1.1
Mali Bandiagara1.1
Tunisia Tunis1.1
Kenya Nandi1.0
Cape Verde SE Islands0.8
Kenya0.7
Uganda Kampala0.6
Brazil Belo Horizonte0.5
South African Natal Zulu0.5
Sudanese0.5
Tunisia0.5
Kenya Luo0.4
Oman0.4
HLA B*1517 frequencies
freq
ref.Population(%)
[3]India Khandesh Pawra9.0
South Africa Natal Tamil3.1
Saudi Arabia Guraiat and Hail2.7
Mexico Zaptotec Oaxaca2.2
India North Hindus1.9
Bulgaria1.8
India North Delhi1.6
China Inner Mongolia1.5
Georgia Tbilisi Georgians1.4
Kenya Luo1.3
Cuban Mulatto1.2
Brazil Belo Horizonte1.1
Cameroon Yaounde1.1
Portugal North1.1
Tunisia Tunis1.1
Kenya Nandi1.0
Portugal Centre1.0
China Qinghai Hui0.9
Israel Ashk. and Non Ashk.i Jews0.9
Azores Terceira Island0.8
Cape Verde Southeastern Islands0.8
France South East0.8
India New Delhi0.8
Russia Tuva pop 20.8
Sudanese0.8
USA African Americans pop30.8
USA Caucasian pop20.8
Brazil0.7
Cuban White0.7
Thailand0.7
USA Philadelphia Caucasians0.7
Cameroon Beti0.6
Romanian0.6
Czech Republic0.5
Singapore Thai0.5
Spain Eastern Andalusia Gipsy0.5

References
  1. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. derived from IMGT/HLA
  3. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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