AR-231,453

AR-231,453 is an agonist for the suggested novel cannabinoid receptor GPR119.[1]

AR-231,453
Identifiers
IUPAC name
  • N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl)amine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H24FN7O5S
Molar mass505.53 g·mol−1
3D model (JSmol)
SMILES
  • Fc2cc(S(=O)(C)=O)ccc2Nc1ncnc(c1N(=O)=O)N(CC3)CCC3c(n4)onc4C(C)C
InChI
  • InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25) Y
  • Key:DGBKNTVAKIFYNU-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

See also

References

  1. Semple G, Fioravanti B, Pereira G, Calderon I, Uy J, Choi K, Xiong Y, Ren A, Morgan M, Dave V, Thomsen W, Unett DJ, Xing C, Bossie S, Carroll C, Chu ZL, Grottick AJ, Hauser EK, Leonard J, Jones RM (2008). "Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119". J Med Chem. 51 (17): 5172–5175. doi:10.1021/jm8006867. PMID 18698756.
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