Triethylenemelamine

Triethylenemelamine
Clinical data
ATC code	None;
Identifiers
	IUPAC name 2,4,6-Tris(aziridin-1-yl)-1,3,5-triazine;
CAS Number	51-18-3 ;
PubChem CID	5799;
ChemSpider	5594 ;
UNII	F7IY6HZG9D;
KEGG	C07642 ;
ChEMBL	ChEMBL502384 ;
CompTox Dashboard (EPA)	DTXSID3026225 ;
ECHA InfoCard	100.000.076
Chemical and physical data
Formula	C9H12N6
Molar mass	204.237 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CN1c2nc(nc(n2)N3CC3)N4CC4;
	InChI InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2 ; Key:IUCJMVBFZDHPDX-UHFFFAOYSA-N ;
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Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy.[1]

It can cause chromatid aberrations in cell models.[2]

References

Wong, Jeannette R.; Morton, Lindsay M.; Tucker, Margaret A.; Abramson, David H.; Seddon, Johanna M.; Sampson, Joshua N.; Kleinerman, Ruth A. (2014). "Risk of Subsequent Malignant Neoplasms in Long-Term Hereditary Retinoblastoma Survivors After Chemotherapy and Radiotherapy". Journal of Clinical Oncology. 32 (29): 3284–3290. doi:10.1200/JCO.2013.54.7844. PMC 4178525. PMID 25185089.
Luippold HE, Gooch PC, Brewen JG (February 1978). "The production of chromosome aberrations in various mammalian cells by triethylenemelamine". Genetics. 88 (2): 317–26. doi:10.1093/genetics/88.2.317. PMC 1213803. PMID 565312.

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