List of autoimmune diseases
This list of autoimmune diseases is categorized by organ and tissue type to help locate diseases that may be similar.
Autoimmune diseases qualifiers
Overview of the qualifiers for the list.
| Other Qualifiers | |
| A | "Accepted" in prior version of this table. |
| C | A disease, regarded as autoimmune, that is often found in individuals with another autoimmune condition. This designation is given to diseases that are classified by Rose and Bona as having "circumstantial" evidence of autoimmune etiology. Diseases in this list with a "C" are, therefore, actual autoimmune diseases, rather than comorbid symptoms, which appear after this list. |
| E | Disease is an autoimmune response triggered by a specific environmental factor. |
| F | Disease is only caused by autoimmunity in only a fraction of those who suffer from it. |
| I | Described as an autoinflammatory disease. |
| L | Evidence to indicate autoimmunity is extremely limited or circumstantial. |
| M | Disease appears under Autoimmune Diseases in MeSH. |
| N | Not listed in prior version of this table. |
| R | Disease appeared in prior version but has been renamed. In renaming, precedence has been given to scientific names over those based on discoverers. |
| S | "Suspected" in the prior version of this table. |
| T | Disease has a known trigger, such as viral infection, vaccination, or injury. |
| X | An extremely rare disease, which would suggest limited opportunity to study it and conclusively determine whether it is caused by autoimmunity. |
| Y | Listed in the prior version of this table with "Accepted/Suspected" left blank. |
Autoimmune diseases
Major organs
| Organ/Tissue type
Disease name |
Level of acceptance for autoimmunity | Hypersensitivity
(I,II,III,IV) |
ICD-9
Codes |
Notes/Autoantibodies/Synonyms/Rare variants |
|---|---|---|---|---|
| Heart | ||||
| Myocarditis[1][2] | Moderate, F, R, A | 391.2422429.0 | Synonyms: Autoimmune myocarditis, Autoimmune cardiomyopathy, Coxsackie myocarditis | |
| Postmyocardial infarction syndrome[2] | Limited, R, Y | 411.0 | Autoantibodies: Myocardial neo-antigens formed as a result of the MI. Synonym: Dressler's syndrome | |
| Postpericardiotomy syndrome | Limited, N | 429.4 | ||
| Subacute bacterial endocarditis (SBE)[3] | Limited, Y | III | 421.0 | Autoantibodies: essential mixed cryoglobulinemia. |
| Kidney | ||||
| Anti-Glomerular Basement Membrane nephritis[4] | Moderate, R, M, A | II | 446.21 | Autoantibodies: Anti-Basement Membrane Collagen Type IV Protein. Synonyms: Goodpastures Syndrome, Glomerulonephritis Type 1 |
| Lupus nephritis | Comorbidity, N | 583.81 | A comorbidity of Systemic Lupus Erythematosus. | |
| Bladder | ||||
| Interstitial cystitis[5] | Limited, S | 595.1 | Mast cells. | |
| Liver | ||||
| Autoimmune hepatitis[6][7][8] | Moderate, A | cell-mediated | 571.42 | Autoantibodies: ANA and SMA, LKM-1, LKM-2 or LKM-3; antibodies against soluble liver antigen (anti-SLA, anti-LP) no autoantibodies detected (~20%). Synonym: Lupoid hepatitis |
| Primary biliary cholangitis (PBC)[9][10][11][12] | Moderate, A | 571.6 | Autoantibodies: Anti-p62, Anti-sp100, Anti-Mitochondrial(M2), Anti-Ro aka SSA. Note that Sjogren's is classified in some places (e.g. MeSH) as rheumatoid disease, but there is no published evidence to support that classification. | |
| Primary sclerosing cholangitis | Limited, Y | 576.1 | Possible overlap with primary biliary cirrhosis. Autoantibodies: HLA-DR52a. | |
| Lung | ||||
| Antisynthetase syndrome | Limited, Y | 279.49 | Autoantibodies: Anti-Jo1, Anti-PL7, Anti-PL12. | |
| Skin | ||||
| Alopecia Areata[13][14] | Moderate, A | 704.01 | Autoantibodies: T-cells. Synonyms: Alopecia areata - Patchy, Totalis, Universalis | |
| Autoimmune Angioedema[15] | Limited, F, N | 277.6 995.1 | ||
| Autoimmune progesterone dermatitis | Limited, X, A | 279.49 | ||
| Autoimmune urticaria[16][17] | Comorbidity, A | 708 | ||
| Bullous pemphigoid[18] | Moderate, Y | 694.5 | Autoantibodies: IgG autoantibodies targeting the type XVII collagen component of hemidesmosomes. | |
| Cicatricial pemphigoid | Limited, R, X, Y | 694.61 | precipitates C3. Autoantibodies: anti-BP-1, anti-BP-2. Synonyms: Benign Mucosal Pemphigoid, Ocular cicatricial pemphigoid | |
| Dermatitis herpetiformis[19] | Moderate, C, Y | 694.0 | Autoantibodies: IgA Eosinophilia; anti-epidermal transglutaminase antibodies. | |
| Discoid lupus erythematosus[20] | Limited, Y | III | 695.4 | IL-2 and IFN-gamma. |
| Epidermolysis bullosa acquisita | Moderate, Y | 694.8 | COL7A1. | |
| Erythema nodosum | Limited, F, Y | 695.2 | ||
| Gestational pemphigoid | Limited, R, Y | 646.8 | Autoantibodies: IgG and C3 misdirected antibodies intended to protect the placenta. | |
| Hidradenitis suppurativa[21] | Limited, C, S | 705.83 | ||
| Lichen planus | Limited, Y | 697.0 | ||
| Lichen sclerosus | Limited, C, Y | 701.0 | ||
| Linear IgA disease (LAD)[22] | Moderate, Y | 646.8 | ||
| Morphea[23] | Limited, C, S | 701.0 | ||
| Pemphigus vulgaris[4][19] | Moderate, M, A | II | 694.4 | Autoantibodies: Anti-Desmoglein 3 eosinophilia. |
| Pityriasis lichenoides et varioliformis acuta | Limited, C | 696.2 | ||
| Mucha–Habermann disease | Limited, C, Y | 696.2 | T-cells. Synonyms: Pityriasis lichenoides, varioliformis acuta | |
| Psoriasis[24] | Moderate, A | IV? | 696 | CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB. |
| Systemic scleroderma[23][25] | Limited, R, S | 710.1 | COL1A2 and TGF-β1. Autoantibodies: Anti-nuclear antibodies, anti-centromere and anti-scl70/anti-topoisomerase antibodies. Synonyms: Diffuse cutaneous systemic sclerosis, Systemic sclerosis, Scleroderma | |
| Vitiligo[26][27] | Limited, C, S | 709.01 | NALP-1 RERE, PTPN22, LPP, IL2RA, GZMB, UBASH3A and C1QTNF6. | |
Glands
| Organ/Tissue type
Disease name |
Level of acceptance for autoimmunity | Hypersensitivity
(I,II,III,IV) |
ICD-9
Codes |
Notes/Autoantibodies/Synonyms/Rare variants |
|---|---|---|---|---|
| Endocrine | ||||
| Adrenal gland | ||||
| Addison's disease[4] | Moderate, F, Y | 255 | Autoantibodies: 21 hydroxylase. | |
| Multi-glandular | ||||
| Autoimmune polyendocrine syndrome (APS) type 1 | Moderate, A | Unknown or multiple | 258.1 | Synonyms: Whitaker's Syndrome, Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), Addisons Disease, Polyglandular Autoimmune Syndrome 1 (PGAS-1). |
| Autoimmune polyendocrine syndrome (APS) type 2[28] | Moderate, A | 258.1 | DQ2, DQ8 and DRB1*0404. Autoantibodies: anti-21 hydroxylase, anti-17 hydroxylase. Synonyms: Schmidt syndrome, Polyglandular Autoimmune Syndrome 2 (PGAS-2). | |
| Autoimmune polyendocrine syndrome (APS) type 3 | Moderate, A | 258.1 | Synonym: Polyglandular Autoimmune Syndrome 3 (PGAS-3). | |
| Pancreas | ||||
| Autoimmune pancreatitis (AIP) | Moderate, A | 577.1 | Autoantibodies: ANA, anti-lactoferrin antibodies, anti-carbonic anhydrase antibodies, rheumatoid factor. | |
| Diabetes mellitus type 1[4] | Moderate, A | IV | 250.01 | HLA-DR3, HLA-DR4. Autoantibodies: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), insulinoma-associated autoantibodies (IA-2), anti-insulin antibodies. |
| Thyroid gland | ||||
| Autoimmune thyroiditis | Strong, A | IV | 245.8 | HLADR5, CTLA-4. Autoantibodies: Antibodies against thyroid peroxidase and/or thyroglobulin. Synonyms: Chronic lymphocytic thyroiditis, Hashimoto's thyroiditis. |
| Ord's thyroiditis | Moderate, Y | 245.8 | ||
| Graves' disease[4] | Moderate, M, A | II | 242.0 | Autoantibodies: Thyroid autoantibodies (TSHR-Ab) that activate the TSH-receptor (TSHR). |
| Exocrine | ||||
| Reproductive organs | ||||
| Autoimmune oophoritis | Moderate, N | 614.2 | ||
| Endometriosis[29] | Limited, S | 617.0 | ||
| Autoimmune orchitis | Limited, N | 604.0 | ||
| Salivary glands | ||||
| Sjögren syndrome[4][10][11][12] | Moderate, A | 710.2 | Autoantibodies: Anti-Ro (often present also in Systemic Lupus Erythematosus). | |
Digestive system
| Organ/Tissue Type
Disease Name |
Level of Acceptance for Autoimmunity | Hypersensitivity
(I,II,III,IV) |
ICD-9
Codes |
Notes/Autoantibodies/Synonyms/Rare Variants |
|---|---|---|---|---|
| Digestive System | ||||
| Autoimmune enteropathy | Moderate, X, Y | |||
| Coeliac disease[30][31][32] | Moderate, A,E | IV?? | 579.0 | HLA-DQ8 and DQ2.5. Autoantibodies: Anti-tissue transglutaminase antibodies, anti-endomysial IgA, anti-gliadin IgA. |
| Crohn's disease[33] | Moderate, Y | IV | 555 | Innate immunity; Th17; Th1; ATG16L1; CARD15; XBP1. |
| Esophageal achalasia | -Limited, X | [34] | ||
| Microscopic colitis | Limited, S | 558.9 | ||
| Ulcerative colitis[4] | Limited, A | IV | 556 | |
Tissue
| Organ/Tissue type
Disease name |
Level of acceptance for autoimmunity | Hypersensitivity
(I,II,III,IV) |
ICD-9
Codes |
Notes/Autoantibodies/Synonyms/Rare variants |
|---|---|---|---|---|
| Blood | ||||
| Antiphospholipid syndrome (APS, APLS)[4] | Moderate, M, A | 289.81 | HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3. Autoantibodies: Anti-cardiolipin; anti-pyruvate dehydrogenase; β2 glycoprotein I; phosphatidylserine; anti-apoH; Annexin A5. Synonym: Hughes syndrome. | |
| Aplastic anemia | Limited, F, Y | 284 | ||
| Autoimmune hemolytic anemia | Moderate, M, A | II | 283.0 | Complement activation. |
| Autoimmune lymphoproliferative syndrome | Moderate, A | 279.41 | TNFRSF6; defective Fas-CD95 apoptosis. Synonym: Canale-Smith syndrome. | |
| Autoimmune neutropenia | Moderate, F, N | 288.09 | ||
| Autoimmune thrombocytopenic purpura[4] | Moderate, M, R, A | 287.31 | Autoantibodies: Anti gpIIb-IIIa or 1b-IX. Synonym: Idiopathic Thrombocytopenic Purpura (ITP) | |
| Cold agglutinin disease | Moderate, M, A | II | 283.0 | Idiopathic or secondary to leukemia or infection. Autoantibodies: IgM. Synonym: Autoimmune hemolytic anemia. |
| Essential mixed cryoglobulinemia | Limited, C, Y | 273.2 | ||
| Evans syndrome | Moderate, Y | 287.32 | Syndrome with a combination of hemolytic anemia and thrombocytopenic purpura | |
| Pernicious anemia[35] | Moderate, A | II | 281.0 | Autoantibodies: Anti-parietal cell antibody. |
| Pure red cell aplasia | Limited, Y | 284.81 | ||
| Thrombocytopenia[36][37] | Limited, F, Y | II | 287.5 | Multiple mechanisms. Autoantibodies: Glycoproteins IIb-IIIa or Ib-IX in ITP anti-ADAMTS13 in TTP. and HUS anti-cardiolipin (anti-cardiolipin antibodies) and β2 glycoprotein I in Antiphospholipid syndrome; anti-HPA-1a, anti-HPA-5b, and others in NAIT. Synonyms: Neonatal thrombocytopenia |
| Connective tissue, systemic, and multi-organ | ||||
| Adiposis dolorosa[38] | Limited, L, S | 272.8 | Lipoid tissue. Synonym: Dercum's disease | |
| Adult-onset Still's disease[39] | Moderate, Y | 714.2 | Macrophage migration inhibitory factor. Autoantibodies: ANA. | |
| Ankylosing spondylitis[15] | Limited, S | 720.0 | CD8; HLA-B27. | |
| CREST syndrome | Limited, Y | 710.1 | Autoantibodies: Anti-centromere antibodies Anti-nuclear antibodies. | |
| Drug-induced lupus | Moderate, Y | 710.0 | Autoantibodies: Anti-histone antibodies. | |
| Enthesitis-related arthritis[40][41][42][43] | Limited, C, Y | MMP3, TRLR2, TLR4, ERAP1. A subtype of Juvenile Rheumatoid Arthritis. | ||
| Eosinophilic fasciitis | Limited, F, A | 728.89 | Synonym: Shulman's syndrome | |
| Felty syndrome[44] | Strong, M, Y | 714.1 | ||
| IgG4-related disease | Limited, C, N | Characteristic histological features (storiform fibrosis, lymphoplasmacytic infiltrate, obliterative phlebitis) are required for definitive diagnosis. Synonyms: IgG4-related systemic disease, IgG4-related sclerosing disease, IgG4-related systemic sclerosing disease, IgG4-related autoimmune disease, IgG4-associated multifocal systemic fibrosis, IgG4-associated disease, IgG4 syndrome, Hyper-IgG4 disease, Systemic IgG4-related plasmacytic syndrome. | ||
| Juvenile arthritis[39] | Strong, M, R, Y | 714.30 | Autoantibodies: inconsistent ANA, Rheumatoid factor. Synonyms: Juvenile rheumatoid arthritis, Juvenile idiopathic arthritis | |
| Lyme disease (chronic)[45] | Limited, L, T, N | 088.81 | ||
| Mixed connective tissue disease (MCTD)[4] | Moderate, M, A | 710.8 | HLA-DR4. Autoantibodies: Anti-nuclear antibody, anti-U1-RNP. | |
| Palindromic rheumatism[46] | Limited, Y | 719.3 | Autoantibodies: Anti-cyclic citrullinated peptide antibodies (anti-CCP) and antikeratin antibodies (AKA). Synonym: Hench-Rosenberg syndrome. | |
| Parry–Romberg syndrome | Limited, Y | 349.89351.8 | Autoantibodies: ANA. | |
| Parsonage–Turner syndrome | Limited, Y | 353.5 | ||
| Psoriatic arthritis[47] | Moderate, C, A | IV? | 696.0 | HLA-B27. |
| Reactive arthritis | Limited, C, F, Y | 099.3 | ||
| Relapsing polychondritis[48] | Strong, A | 733.99 | Synonyms: Atrophic polychondritis, systemic chondromalacia, chronic atrophic polychondritis, Meyenburg-Altherr-Uehlinger syndrome, generalized chondromalacia, systemic chondromalacia | |
| Retroperitoneal fibrosis | Limited, Y | 593.4 | ||
| Rheumatic fever[49][50] | Moderate, T, A | II | 390 | Autoantibodies: Streptococcal M protein cross reacts with human myosin. |
| Rheumatoid arthritis[4] | Strong, M, A | III | 714 | HLA-DR4, PTPN22, depleted B cells, TNF alpha, IL-17, (also maybe IL-1, 6, and 15). Autoantibodies: Rheumatoid factor (anti-IgGFc), Anti-MCV, ACPAs(Vimentin). |
| Sarcoidosis[51][52][53] | Limited, S | IV | 135 | BTNL2; HLA-B7-DR15; HLA DR3-DQ2. |
| Schnitzler syndrome | Limited, L, X, Y | 273.1 | IgM. | |
| Systemic lupus erythematosus (SLE)[4][10][11][12][19][54] | Strong, M, A | III | 695.4 | Autoantibodies: Anti-nuclear antibodies, anti-Ro (often present also in Sjögren syndrome). Eosinophilia. Synonym: Lupus |
| Undifferentiated connective tissue disease (UCTD) | Moderate, C, A | 710.9 | HLA-DR4. Autoantibodies: anti-nuclear antibody. Synonyms: Latent lupus, incomplete lupus | |
| Muscle | ||||
| Dermatomyositis[55][56] | Moderate, F, X, A | 710.3 | B- and T-cell perivascular inflammatory infiltrate on muscle biopsy. Autoantibodies: histidine-tRNA anti-signal recognition peptide Anti-Mi-2 Anti-Jo1. Synonym: Juvenile dermatomyositis | |
| Fibromyalgia | Limited, C, F, N | 729.1 | ||
| Inclusion body myositis | Limited, F, Y | 359.71 | Similar to polymyositis, but does not respond to steroid therapy-activated T8 cells. | |
| Myositis | Limited, F, Y | 729.1 | ||
| Myasthenia gravis[4] | Strong, M, A | II | 358 | HA-B8 HLA-DR3 HLA-DR1. Autoantibodies: Nicotinic acetylcholine receptor MuSK protein. |
| Neuromyotonia[57] | Limited, F, S | II? | 333.90 | Autoantibodies: Voltage-gated potassium channels. Synonym: Isaacs' syndrome |
| Paraneoplastic cerebellar degeneration[58][59][60] | Limited, Y | IV? II? | 334.9 | Autoantibodies: anti-Yo (anti-cdr-2 in purkinje fibers) anti-Hu, anti-Tr, antiglutamate receptor. |
| Polymyositis[55] | Limited, F, A | 710.4 | Autoantibodies: IFN-gamma, IL-1, TNF-alpha, Anti-Jo1, Anti-SRP. | |
| Nervous system | ||||
| Acute disseminated encephalomyelitis (ADEM) | Strong, M, T, A | 323.61323.81 | Synonyms: Perivenous encephalomyelitis, Acute hemorrhagic leukoencephalitis (AHL, AHLE), Acute necrotizing encephalopathy (ANE), Acute hemorrhagic encephalomyelitis (AHEM), Acute necrotizing hemorrhagic leukoencephalitis (ANHLE), Weston-Hurst syndrome, Hurst's disease. | |
| Acute motor axonal neuropathy[61] | Limited, N | 356.8 | ||
| Anti-N-Methyl-D-Aspartate (Anti-NMDA) Receptor Encephalitis[62] | Moderate, N | |||
| Balo concentric sclerosis | Moderate, Y | 341.1 | Synonyms: Balo disease, Schilders disease. | |
| Bickerstaff's encephalitis | Limited, Y | 323.62 | Similar to Guillain–Barré syndrome. Autoantibodies: Anti-GQ1b 2/3 patients. | |
| Chronic inflammatory demyelinating polyneuropathy[63] | Moderate, C, Y | 357.81 | Similar to Guillain–Barré syndrome. Autoantibodies: Anti-ganglioside antibodies. Synonyms: Relapsing polyneuropathy (CRP), chronic inflammatory demyelinating polyradiculoneuropathy, Chronic inflammatory demyelinating polyneuritis. | |
| Guillain–Barré syndrome[4] | Strong, M, A | IV | 357.0 | Autoantibodies: Anti-ganglioside, anti-GQ1b. Synonyms: Miller–Fisher syndrome, Landry's paralysis. |
| Hashimoto's encephalopathy[4][64] | Moderate, C, X, A | IV | Autoantibodies: Alpha-enolase. Synonyms: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), Nonvasculitic autoimmune meningoencephalitis (NAIM), Encephalopathy Associated with Autoimmune Thyroid Disease (EAATD). | |
| Idiopathic inflammatory demyelinating diseases | Limited, F, Y | 356.8 | A set of different variants of multiple sclerosis. | |
| Lambert–Eaton myasthenic syndrome | Strong, M, Y | 358.1 | HLA-DR3-B8. Autoantibodies: Voltage-gated calcium channels; Q-type calcium channel, synaptogagmin, muscarinic acetylcholine receptor M1. | |
| Multiple sclerosis, pattern II[65][66] | Strong, M, A | IV | 340 | Autoantibody against potassium channel has been reported to present demyelination pattern II. Other cases present autoimmunity against MOG[67] and Anoctamin-2.[68] The three reported autoimmune variants belong to MS pattern II. Also involved HLA-DR2, PECAM-1, Anti-myelin basic protein. Autoantibodies: Anti-Kir4.1, Anti-MOG, Anti-ANO2 (heterogeneous). Synonyms: Primary progressive multiple sclerosis, Relapsing-remitting multiple sclerosis, disseminated sclerosis, encephalomyelitis disseminata. Also interesting is Multiple sclerosis with HLA-DRB3 histocompatibility. In this case the auto-antigen has been found and is GDP-L-fucose synthase[69] |
| Oshtoran syndrome[70] | X | F06.9 | Heritable, abnormalities in the kynurenine and glutamate metabolism. | |
| Progressive inflammatory neuropathy | Limited, X, S | 356.4 | Similar to Guillain–Barré syndrome. Autoantibodies: Anti-ganglioside antibodies:anti-GM1, anti-GD1a, anti-GQ1b. | |
| Restless legs syndrome | Limited, C, S | 333.94 | May occur in Sjögren syndrome, coeliac disease and rheumatoid arthritis, or in derangements of iron metabolism. | |
| Stiff-person syndrome[71] | Limited, S | 333.91 | GLRA1 (glycine receptor). Autoantibodies: Glutamic acid decarboxylase (GAD). | |
| Sydenham's chorea | Limited, T, Y | 392 | ||
| Transverse myelitis | Limited, M, A | 323.82341.2 | ||
| Eyes | ||||
| Autoimmune retinopathy[72] | Limited, X, N | |||
| Autoimmune uveitis | Moderate, F, A | 364 | Autoantibodies: HLAB-27. | |
| Cogan syndrome | Limited, F, Y | 370.52 | ||
| Graves' ophthalmopathy | Moderate, M, N | 242.9 | ||
| Intermediate uveitis | Limited, L, Y | 364.3 | Synonyms: Pars planitis, peripheral uveitis. | |
| Ligneous conjunctivitis | Limited, L, N | 372.39 | ||
| Mooren's ulcer | Limited, L, N | 370.07 | ||
| Neuromyelitis optica[73][74] | Limited, M, Y | II? | 341.0 | Autoantibodies: NMO-IgG aquaporin 4. Synonym: Devic's disease. |
| Opsoclonus myoclonus syndrome[75] | Limited, X, S | IV? | 379.59 | Lymphocyte recruitment to CSF. |
| Optic neuritis | Limited, C, Y | 377.30 | ||
| Scleritis | Limited, C, Y | 379.0 | ||
| Susac's syndrome | Limited, C, Y | 348.39 | Synonym: Retinocochleocerebral vasculopathy. | |
| Sympathetic ophthalmia | Limited, I, Y | 360.11 | Autoantibodies: ocular antigens following trauma. | |
| Tolosa–Hunt syndrome | Limited, I, X, Y | 378.55 | ||
| Ears | ||||
| Autoimmune inner ear disease (AIED)[76] | Limited, A | 388.8 | ||
| Ménière's disease[77] | Limited, Y | III? | 386.00 | Autoantibodies: Major peripheral myelin protein P0. |
| Vascular system | ||||
| Behçet's disease | Limited, I, X, A | 136.1 | An immune-mediated systemic vasculitis; linkage to HLA-B51 (HLA-B27); very variable manifestations, with ulcers as common symptom. Synonyms: Morbus Adamandiades-Behçet. Rare variant: Hughes–Stovin syndrome. | |
| Eosinophilic granulomatosis with polyangiitis (EGPA)[19][78] | Limited, I, X, Y | 446.4 | Autoantibodies: p-ANCA Eosinophilia. | |
| Giant cell arteritis[4] | Limited, I, R, A | IV | 446.5 | Synonyms: Cranial arteritis, temporal arteritis. |
| Granulomatosis with polyangiitis (GPA)[78] | Strong, M, A | 446.4 | Autoantibodies: Anti-neutrophil cytoplasmic (cANCA). | |
| IgA vasculitis (IgAV)[78] | Limited, L, Y | 287.0 | Autoantibodies: IgA and complement component 3 (C3). Synonyms: Anaphylactoid purpura, Henoch-Schonlein purpura, purpura rheumatica, Schönlein–Henoch purpura. | |
| Kawasaki disease | Moderate, S,E[79] | 446.1 | ITPKC HLA-B51. Synonyms: Kawasaki syndrome, lymph node syndrome, mucocutaneous lymph node syndrome. | |
| Leukocytoclastic vasculitis | Limited, L, Y | 447.6 | ||
| Lupus vasculitis | Moderate, C, N | 583.81 | A comorbidity of systemic lupus erythematosus. | |
| Rheumatoid vasculitis | Moderate, C, N | 447.6 | A symptom of lupus. | |
| Microscopic polyangiitis (MPA) | Limited, Y | 446.0 | Binds to neutrophils causing them to degranulate and damages endothelium. Autoantibodies: p-ANCA myeloperoxidase. Synonyms: Microscopic polyarteritis, microscopic polyarteritis nodosa. | |
| Polyarteritis nodosa (PAN) | Limited, L, Y | 446.0 | Synonyms: Panarteritis nodosa, periarteritis nodosa, Kussmaul disease, Kussmaul–Maier disease. | |
| Polymyalgia rheumatica | Limited, L, Y | 725 | ||
| Urticarial vasculitis[80] | Limited, X, Y | II? | 708.9 | Clinically may resemble type I hypersensitivity. Autoantibodies: anti C1q antibodies. |
| Vasculitis[18] | Strong, I, M, F, A | III | 447.6 | Autoantibodies: ANCA (sometimes). |
| Systemic | ||||
| Primary immunodeficiency | Limited, N | |||
Autoimmune comorbidities
This list includes conditions that are not diseases but signs common to autoimmune disease. Some, such as chronic fatigue syndrome, are controversial.[2] These conditions are included here because they are frequently listed as autoimmune diseases but should not be included in the list above until there is more consistent evidence.
| Organ/Tissue Type
Disease Name |
Level of Acceptance for Autoimmunity | Hypersensitivity
(I,II,III,IV) |
ICD-9
Codes |
Notes/Autoantibodies/Synonyms |
|---|---|---|---|---|
| Chronic fatigue syndrome | Comorbidity, N | Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease. | ||
| Complex regional pain syndrome | Comorbidity, N | Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease. Synonyms: Amplified Musculoskeletal Pain Syndrome, Reflex Neurovascular Dystrophy, Reflex sympathetic dystrophy | ||
| Eosinophilic esophagitis | Comorbidity, N | 530.13 | ||
| Gastritis | Comorbidity, Y | Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease. Autoantibodies: serum antiparietal and anti-IF antibodies. | ||
| Interstitial lung disease | Comorbidity, N | Associated with several autoimmune connective tissue diseases. | ||
| POEMS syndrome[81] | Comorbidity, Y | Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease. Autoantibodies: interleukin 1β, interleukin 6 and TNFα. vascular endothelial growth factor (VEGF), given the .. | ||
| Raynaud's phenomenon | Comorbidity, S | Symptomatic of autoimmune diseases or autoimmune activity, but not a disease or a cause of disease. | ||
| Primary immunodeficiency[82] | Comorbidity, N | 279.8 | The condition is inherited, but it is associated with several autoimmune diseases. | |
| Pyoderma gangrenosum | Comorbidity, Y | Possibly symptomatic of autoimmune diseases, but not a disease or a cause of disease. |
Non-autoimmune
At this time, there is not sufficient evidence—direct, indirect, or circumstantial—to indicate that these diseases are caused by autoimmunity. These conditions are included here because:
- The disease was listed in the prior version of this table
- The disease is included in several widely used lists of autoimmune disease and is shown here to ensure that a person visiting this page does not conclude that the disease was not considered. Before moving a condition from here to the list of autoimmune diseases, references should be provided in the Wikipedia page for the condition that point to evidence, direct or indirect, that it is an autoimmune disease.
| Organ/Tissue Type
Disease Name |
Level of Acceptance for Autoimmunity | Hypersensitivity
(I,II,III,IV) |
ICD-9
Codes |
Notes/Autoantibodies/Synonyms |
|---|---|---|---|---|
| Agammaglobulinemia | Not Autoimmune, Y | 279.00 | An immune system disorder but not an autoimmune disease.. Autoantibodies: IGHM; IGLL1: CD79A; CD79B; BLNK; LRRC8A. | |
| Amyloidosis | Not Autoimmune, N | 277.30 | No consistent evidence of association with autoimmunity. | |
| Amyotrophic lateral sclerosis | Not Autoimmune, Y | 335.20 | No consistent evidence of association with autoimmunity. Autoantibodies: Amyotrophic lateral sclerosis (Also Lou Gehrig's disease; Motor Neuron Disease). | |
| Anti-tubular basement membrane nephritis | Not Autoimmune, N | No consistent evidence of association with autoimmunity. | ||
| Atopic allergy | Not Autoimmune, Y | I | 691.8 | A hypersensitivity. |
| Atopic dermatitis | Not Autoimmune, Y | I | 691.8 | A hypersensitivity. |
| Autism | Not Autoimmune, N | No consistent evidence of association with maternal autoimmunity. | ||
| Autoimmune peripheral neuropathy | Not Autoimmune, F, A | A symptom of many diseases, including some that may be autoimmune. Not an autoimmune disease. | ||
| Blau syndrome | Not Autoimmune, Y | Overlaps both sarcoidosis and granuloma annulare. No evidence of association with autoimmunity. | ||
| Cancer | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. | ||
| Castleman's disease | Not Autoimmune, Y | An immune system disorder but not an autoimmune disease.. Autoantibodies: Over expression of IL-6. | ||
| Chagas disease[83] | Not Autoimmune, S | No consistent evidence of association with autoimmunity. | ||
| Chronic obstructive pulmonary disease[84][85] | Not Autoimmune, S | No consistent evidence of association with autoimmunity. | ||
| Chronic recurrent multifocal osteomyelitis | Not Autoimmune, Y | LPIN2, D18S60. Synonyms: Majeed syndrome | ||
| Complement component 2 deficiency | Not Autoimmune, Y | Possibly symptomatic of autoimmune diseases, but not a disease. | ||
| Congenital heart block | Not Autoimmune, N | May be related to autoimmune activity in the mother. | ||
| Contact dermatitis | Not Autoimmune, Y | IV | A hypersensitivity. | |
| Cushing's syndrome | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. | ||
| Cutaneous leukocytoclastic angiitis | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. Autoantibodies: neutrophils. | ||
| Dego's disease | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. | ||
| Eczema | Autoimmune, Y | eczema is an autoimmune disease. It was previously thought not to be, but has been accepted as an autoimmune disease since at least 2014. Eczema and Psoriasis are both autoimmune diseases. | ||
| Eosinophilic gastroenteritis | Not Autoimmune, Y | Possibly a hypersensitivity. Autoantibodies: IgE, IL-3, IL-5, GM-CSF, eotaxin. | ||
| Eosinophilic pneumonia | Not Autoimmune, F, Y | A class of diseases, some of which may be autoimmune. Specifically, Churg–Strauss syndrome, a subtype of Eosinophilic pneumonia, is autoimmune. | ||
| Erythroblastosis fetalis | Not Autoimmune, Y | II | Mother's immune system attacks fetus. An immune system disorder but not autoimmune. Autoantibodies: ABO, Rh, Kell antibodies. | |
| Fibrodysplasia ossificans progressiva | Not Autoimmune, Y | Possibly an immune system disorder but not autoimmune. Autoantibodies: ACVR1 Lymphocytes express increased BMP4. | ||
| Gastrointestinal pemphigoid | Not Autoimmune, A | No consistent evidence of association with autoimmunity. | ||
| Hypogammaglobulinemia | Not Autoimmune, Y | An immune system disorder but not autoimmune. Autoantibodies: IGHM, IGLL1, CD79A, BLNK, LRRC8A, CD79B. | ||
| Idiopathic giant-cell myocarditis[86] | Not Autoimmune, N | No consistent evidence of autoimmune cause though the disease has been found comorbid with other autoimmune diseases. Synonyms: Giant cell myocarditis | ||
| Idiopathic pulmonary fibrosis[87] | Not Autoimmune, Y | Autoantibodies: SFTPA1, SFTPA2, TERT, and TERC.. Synonyms: Fibrosing alveolitis | ||
| IgA nephropathy | Not Autoimmune, Y | III? | Autoantibodies: IgA produced from marrow rather than MALT. Synonyms: IgA nephrits, Berger's disease, Synpharyngitic Glomerulonephritis. An immune system disorder but not an autoimmune disease. | |
| Immunoregulatory lipoproteins[88] | Not Autoimmune, N | Not a disease. | ||
| IPEX syndrome | Not Autoimmune, N | A genetic mutation in FOXP3 that leads to autoimmune diseases, but no consistent evidence that it is an autoimmune disorder itself.. Synonyms: X-linked polyendocrinopathy, immunodeficiency and diarrhea-syndrome (XLAAD) | ||
| Ligneous conjunctivitis | Not Autoimmune, N | No consistent evidence of association with autoimmunity. | ||
| Majeed syndrome | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. Autoantibodies: LPIN2. | ||
| Narcolepsy[89][90][91][92] | Not Autoimmune, Y | II? | No evidence of association with autoimmunity. Research not reproducible. Autoantibodies: hypocretin or orexin, HLA-DQB1*0602. | |
| Rasmussen's encephalitis | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. Autoantibodies: anti-NR2A antibodies. | ||
| Schizophrenia[93][94][95] | Not Autoimmune, S | No consistent evidence of association with autoimmunity. | ||
| Serum sickness | Not Autoimmune, Y | III | A hypersensitivity. | |
| Spondyloarthropathy | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. Autoantibodies: HLA-B27. | ||
| Sweet's syndrome | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. Autoantibodies: GCSF. | ||
| Takayasu's arteritis | Not Autoimmune, Y | No consistent evidence of association with autoimmunity. | ||
| Undifferentiated spondyloarthropathy | Not Autoimmune, Y | See Enthesitis-related arthritis. |
See also
References
- ↑ Root-Bernstein, Robert; Fairweather, DeLisa (December 2014). "Unresolved issues in theories of autoimmune disease using myocarditis as a framework". Journal of Theoretical Biology. 375: 101–23. doi:10.1016/j.jtbi.2014.11.022. PMC 4417457. PMID 25484004.
- 1 2 3 MacKay, Ian R.; Rose, Noel Richard, eds. (2014). The autoimmune diseases (Fifth ed.). [S.l.]: Academic Press. p. Chapter 70. ISBN 978-0-12-384929-8.
- ↑ Agarwal A, Clements J, Sedmak DD, et al. (December 1997), "Subacute bacterial endocarditis masquerading as type III essential mixed", Journal of the American Society of Nephrology, 8 (12): 1971–6, doi:10.1681/ASN.V8121971, PMID 9402102
- 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Autoimmune+Diseases at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ Kárpáti F, Dénes L, Büttner K (1975). "[Interstitial cystitis=autoimmune cyatitis? Interstitial as a participating disease in lupus erythematosus]". Zeitschrift für Urologie und Nephrologie (in German). 68 (9): 633–9. PMID 1227191.
- ↑ Bogdanos DP, Invernizzi P, Mackay IR, Vergani D (June 2008). "Autoimmune liver serology: Current diagnostic and clinical challenges". World Journal of Gastroenterology. 14 (21): 3374–3387. doi:10.3748/wjg.14.3374. PMC 2716592. PMID 18528935. Archived from the original on 2011-09-29.
- ↑ "autoimmune hepatitis".
- ↑ "Medscape & eMedicine Log In".
- ↑ "Primary Biliary Cirrhosis: Fatty Liver, Cirrhosis, and Related Disorders: Merck Manual Home Health Handbook". Retrieved 2008-04-05.
- 1 2 3 Franceschini F, Cavazzana I (2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706. S2CID 24327937.
- 1 2 3 Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55–63. doi:10.1080/08916930400022954. PMID 15804706. S2CID 24327937.
- 1 2 3 Goëb V, Salle V, Duhaut P, Jouen F, Smail A, Ducroix JP, Tron F, Le Loët X, Vittecoq O (2007). "Clinical significance of autoantibodies recognizing Sjogren's syndrome A (SSA), SSB, calpastatin and alpha-fodrin in primary Sjogren's syndrome". Clinical and Experimental Immunology. 148 (2): 281–7. doi:10.1111/j.1365-2249.2007.03337.x. PMC 1868868. PMID 17286756.
- ↑ American Academy of Dermatology, "Archived copy". Archived from the original on 2010-07-06. Retrieved 2010-07-16.
{{cite web}}: CS1 maint: archived copy as title (link) - ↑ HtmlThe University of Texas MD Anderson Cancer Center, http://www.mdanderson.org/patient-and-cancer-information/cancer-information/cancer-types/alopecia-areata/index.html Archived 2011-11-05 at the Wayback Machine
- 1 2 Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A (2002). "Ankylosing spondylitis: an overview". Annals of the Rheumatic Diseases. 61 (3): iii8–18. doi:10.1136/ard.61.suppl_3.iii8. PMC 1766729. PMID 12381506.
- ↑ Soundararajan S, Kikuchi Y, Kusumam J, Kaplan AP (2004). "Functional | assessment of pathogenic IgG subclass in chronic autoimmune urticaria". The Journal of Allergy and Clinical Immunology. 115 (4): 815–21. doi:10.1016/j.jaci.2004.12.1120. PMID 15806004.
- ↑ Goh, CL; Tan, KT (2009). "Chronic autoimmune urticaria : Where we stand ?". Indian Journal of Dermatology. 54 (3): 269–74. doi:10.4103/0019-5154.55640. PMC 2810697. PMID 20161862.
- 1 2 "Autoimmune Disorders: Immune Disorders: Merck Manual Home Health Handbook".
- 1 2 3 4 Table 12-6 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). Robbins Basic Pathology. Philadelphia: Saunders. ISBN 978-1-4160-2973-1. 8th edition.
- ↑ Toro JR, Finlay D, Dou X, Zheng SC, LeBoit PE, Connoly KM (2000). "Detection of Type 1 Cytokines in Discoid Lupus Erythematosus". Archives of Dermatology. 136 (12): 1497–1501. doi:10.1001/archderm.136.12.1497. PMID 11115160.
- ↑ "Clinical Trial: Etanercept in Hidradenitis Suppurativa". Retrieved 2007-07-08.
- ↑ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
- 1 2 Takehara K, Sato S (2005). "Localized scleroderma is an autoimmune disorder". Rheumatology. 44 (3): 274–9. doi:10.1093/rheumatology/keh487. PMID 15561734.
- ↑ National Psoriasis Foundation, http://www.psoriasis.org/home/learn01.php
- ↑ Jimenez SA, Derk CT (2004). "Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis". Annals of Internal Medicine. 140 (1): 37–50. doi:10.7326/0003-4819-140-2-200401200-00013. PMID 14706971.
- ↑ "Questions and Answers about Vitiligo". Retrieved 2007-08-06.
- ↑ "A New Gene Linked to Vitiligo and Susceptibility to Autoimmune Disorders - Journal Watch Dermatology". Archived from the original on 3 September 2007. Retrieved 2007-08-06.
- ↑ de Carmo Silva R, Kater CE, Dib SA, Laureti S, Forini F, Cosentino A, Falorni A (February 2000). "Autoantibodies against recombinant human steroidogenic enzymes 21-hydroxylase, side-chain cleavage and 17alpha-hydroxylase in Addison's disease and autoimmune polyendocrine syndrome type III". European Journal of Endocrinology. 142 (2): 187–94. doi:10.1530/eje.0.1420187. PMID 10664529. Retrieved 2008-07-25.
- ↑ Gleicher N, el-Roeiy A, Confino E, Friberg J (1987). "Is endometriosis an autoimmune disease?". Obstetrics and Gynecology. 70 (1): 115–22. PMID 3110710.
- ↑ "Celiac Disease". Archived from the original on 2009-07-20.
- ↑ Meize-Grochowski R (2005). "Celiac disease: a multisystem autoimmune disorder". Gastroenterology Nursing. 28 (5): 394–402, quiz 403–4. doi:10.1097/00001610-200509000-00005. PMID 16234635. S2CID 44364035.
- ↑ Sollid LM, Jabri B (December 2005). "Is celiac disease an autoimmune disorder?". Current Opinion in Immunology. 17 (6): 595–600. doi:10.1016/j.coi.2005.09.015. PMID 16214317.
- ↑ Dessein, R; Chamaillard, M; Danese, S (Sep 2008). "Innate immunity in Crohn's disease: the reverse side of the medal". Journal of Clinical Gastroenterology. 42 Suppl 3 Pt 1: S144–7. doi:10.1097/MCG.0b013e3181662c90. PMID 18806708.
- ↑ "Idiopathic achalasia | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".
- ↑ "MedlinePlus Medical Encyclopedia: Pernicious anemia". Archived from the original on 9 May 2008. Retrieved 2008-04-05.
- ↑ Moake JL (2004). "von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. 41 (1): 4–14. doi:10.1053/j.seminhematol.2003.10.003. PMID 14727254.
- ↑ Mueller-Eckhardt C, Kiefel V, Grubert A, Kroll H, Weisheit M, Schmidt S, Mueller-Eckhardt G, Santoso S (1989). "348 cases of fetal alloimmune thrombocytopenia". The Lancet. 1 (8634): 363–6. doi:10.1016/S0140-6736(89)91733-9. PMID 2563515. S2CID 30147670.
- ↑ Singal A, Janiga JJ, Bossenbroek NM, Lim HW (May 2007). "Dercum's disease (adiposis dolorosa): a report of improvement with infliximab and methotrexate". Journal of the European Academy of Dermatology and Venereology. 21 (5): 717. doi:10.1111/j.1468-3083.2006.02021.x. PMID 17448013. S2CID 12981175.
- 1 2 De Benedetti F, Meazza C, Vivarelli M, Rossi F, Pistorio A, Lamb R, Lunt M, Thomson W, Ravelli A, Donn R, Martini A (May 2003). "Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis". Arthritis & Rheumatology. 48 (5): 1398–407. doi:10.1002/art.10882. PMID 12746913.
- ↑ Colbert RA (2010). "Classification of juvenile spondyloarthritis: Enthesitis-related arthritis and beyond". Nature Reviews Rheumatology. 6 (8): 477–85. doi:10.1038/nrrheum.2010.103. PMC 2994189. PMID 20606622.
- ↑ Viswanath V, Myles A, Dayal R, Aggarwal A (2011). "Levels of Serum Matrix Metalloproteinase-3 Correlate with Disease Activity in the Enthesitis-related Arthritis Category of Juvenile Idiopathic Arthritis". The Journal of Rheumatology. 38 (11): 2482–7. doi:10.3899/jrheum.110352. PMID 21885500. S2CID 10897674.
- ↑ Myles A, Aggarwal A (March 2011). "Expression of Toll-like receptors 2 and 4 is increased in peripheral blood and synovial fluid monocytes of patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis". Rheumatology. 50 (3): 481–8. doi:10.1093/rheumatology/keq362. PMID 21097451.
- ↑ Hinks A, Martin P, Flynn E, Eyre S, Packham J, Barton A, Worthington J, Thomson W (2001). "Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis". Arthritis Research & Therapy. 13 (1): R12. doi:10.1186/ar3235. PMC 3241356. PMID 21281511.
- ↑ FC Lafeber GJ, de Vries E, van Krieken JH, Cats A (1986). "Immune complexes and the pathogenesis of neutropenia in Felty's syndrome". Annals of the Rheumatic Diseases. 45 (8): 696–702. doi:10.1136/ard.45.8.696. PMC 1001970. PMID 3740999.
- ↑ Borchers, Andrea T.; Keen, Carl L.; Huntley, Arthur C.; Gershwin, M. Eric (February 2015). "Lyme disease: A rigorous review of diagnostic criteria and treatment". Journal of Autoimmunity. 57: 82–115. doi:10.1016/j.jaut.2014.09.004. PMID 25451629.
- ↑ Powell A, Davis P, Jones N, Russell AS (June 2008). "Palindromic rheumatism is a common disease: comparison of new-onset palindromic rheumatism compared to new-onset rheumatoid arthritis in a 2-year cohort of patients". The Journal of Rheumatology. 35 (6): 992–4. PMID 18412310. Archived from the original on 2011-10-01.
- ↑ National Psoriasis Foundation, http://www.psoriasis.org/home/learn02.php
- ↑ "Relapsing Polychondritis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook".
- ↑ Girschick HJ, Guilherme L, Inman RD, Latsch K, Rihl M, Sherer Y, Shoenfeld Y, Zeidler H, Arienti S, Doria A (2008). "Bacterial triggers and autoimmune rheumatic diseases". Clinical and Experimental Rheumatology. 26 (1 Suppl 48): S12–7. PMID 18570749.
- ↑ Faé KC, da Silva DD, Oshiro SE, Tanaka AC, Pomerantzeff PM, Douay C, Charron D, Toubert A, Cunningham MW, Kalil J, Guilherme L (May 2006). "Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease". Journal of Immunology. 176 (9): 5662–70. doi:10.4049/jimmunol.176.9.5662. PMID 16622036.
- ↑ "eMedicine - Hypersensitivity Reactions, Delayed : Article by Walter Duane Hinshaw". Archived from the original on 2008-09-15. Retrieved 2008-09-18.
- ↑ Morell F, Levy G, Orriols R, Ferrer J, De Gracia J, Sampol G (April 2002). "Delayed cutaneous hypersensitivity tests and lymphopenia as activity markers in sarcoidosis". Chest. 121 (4): 1239–44. doi:10.1378/chest.121.4.1239. PMID 11948059.
- ↑ Grunewald J, Eklund A, Olerup O (March 2004). "Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients". American Journal of Respiratory and Critical Care Medicine. 169 (6): 696–702. CiteSeerX 10.1.1.321.2788. doi:10.1164/rccm.200303-459OC. PMID 14656748.
- ↑ Ehrenstein MR (August 1999). "Antinuclear antibodies and lupus: causes and consequences". Rheumatology. 38 (8): 691–3. doi:10.1093/rheumatology/38.8.691. PMID 10501412.
- 1 2 "Polymyositis and Dermatomyositis: Autoimmune Disorders of Connective Tissue: Merck Manual Home Health Handbook".
- ↑ Ghirardello A, Zampieri S, Tarricone E, Iaccarino L, Bendo R, Briani C, Rondinone R, Sarzi-Puttini P, Todesco S, Doria A (May 2006). "Clinical implications of autoantibody screening in patients with autoimmune myositis". Autoimmunity. 39 (3): 217–221. doi:10.1080/08916930600622645. PMID 16769655. S2CID 2411394.
- ↑ Maddison P (2006). "Neuromyotonia". Clinical Neurophysiology. 117 (10): 2118–27. doi:10.1016/j.clinph.2006.03.008. PMID 16843723. S2CID 235331553.
- ↑ Darnell, R.B. (1996), "Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain", Proceedings of the National Academy of Sciences of the United States of America, 93 (10): 4529–4536, Bibcode:1996PNAS...93.4529D, doi:10.1073/pnas.93.10.4529, PMC 39311, PMID 8643438
- ↑ Peterson K, Rosenblum MK, Kotanides H, Posner JB (1992). "Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients". Neurology. 42 (10): 1931–7. doi:10.1212/wnl.42.10.1931. PMID 1407575.
- ↑ Albert ML, Austin LM, Darnell RB (2000). "Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration". Annals of Neurology. 47 (1): 9–17. doi:10.1002/1531-8249(200001)47:1<9::aid-ana5>3.0.co;2-i. PMID 10632096.
- ↑ Lim, JP; Devaux, J; Yuki, N (October 2014). "Peripheral nerve proteins as potential autoantigens in acute and chronic inflammatory demyelinating polyneuropathies". Autoimmunity Reviews. 13 (10): 1070–8. doi:10.1016/j.autrev.2014.08.005. PMID 25172243.
- ↑ Tanaka, K (2014). "[Autoimmune encephalitis-update: roles of autoantibodies in the pathogenesis]". Rinsho Shinkeigaku. 54 (12): 1107–9. doi:10.5692/clinicalneurol.54.1107. PMID 25672721.
- ↑ MacKay, Ian R.; Rose, Noel Richard, eds. (2014). The autoimmune diseases (Fifth ed.). [S.l.]: Academic Press. p. Chapter 75. ISBN 978-0-12-384929-8.
- ↑ Yoneda M, Fujii A, Ito A, Yokoyama H, Nakagawa H, Kuriyama M (April 2007). "High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy". Journal of Neuroimmunology. 185 (1–2): 195–200. doi:10.1016/j.jneuroim.2007.01.018. PMID 17335908. S2CID 11857420.
- ↑ Srivastava, Rajneesh; Aslam, Muhammad; Kalluri, Sudhakar Reddy; Schirmer, Lucas; Buck, Dorothea; Tackenberg, Björn; Rothhammer, Veit; Chan, Andrew; Gold, Ralf; Berthele, Achim; Bennett, Jeffrey L.; Korn, Thomas; Hemmer, Bernhard (2012). "Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis". New England Journal of Medicine. 367 (2): 115–123. doi:10.1056/NEJMoa1110740. PMC 5131800. PMID 22784115.
- ↑ Kalinowska A, Losy J (2006). "PECAM-1, a key player in neuroinflammation". European Journal of Neurology. 13 (12): 1284–90274. doi:10.1111/j.1468-1331.2006.01640.x. PMID 17116209. S2CID 22437957.
- ↑ Jarius S, Metz I, König FB, Ruprecht K, Reindl M, Paul F, Brück W, Wildemann B (2016). "Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case". Multiple Sclerosis Journal. 22 (12): 1541–1549. doi:10.1177/1352458515622986. PMID 26869529. S2CID 1387384.
- ↑ Ayoglu B (2016). "Anoctamin 2 identified as an autoimmune target in multiple sclerosis". Proceedings of the National Academy of Sciences. 113 (8): 2188–2193. Bibcode:2016PNAS..113.2188A. doi:10.1073/pnas.1518553113. PMC 4776531. PMID 26862169.
- ↑ R Planas et al. (2018). "GDP-l-fucose synthase is a CD4+ T cell–specific autoantigen in DRB3*02:02 patients with multiple sclerosis" (PDF). Science Translational Medicine. 10 (462): eaat4301. doi:10.1126/scitranslmed.aat4301. PMID 30305453. S2CID 52959112.
{{cite journal}}: CS1 maint: uses authors parameter (link) - ↑ "Oshtoran Syndrome Research Group - issuu".
- ↑ Murinson BB (2004). "Stiff-person syndrome". Neurologist. 10 (3): 131–7. doi:10.1097/01.nrl.0000126587.37087.1a. PMID 15140273. S2CID 41638783.
- ↑ Grange, Landon; Dalal, Monica; Nussenblatt, Robert B.; Sen, H. Nida (February 2014). "Autoimmune Retinopathy". American Journal of Ophthalmology. 157 (2): 266–272.e1. doi:10.1016/j.ajo.2013.09.019. PMC 3946999. PMID 24315290.
- ↑ Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR (2005). "IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel". Journal of Experimental Medicine. 202 (4): 473–477. doi:10.1084/jem.20050304. PMC 2212860. PMID 16087714.
- ↑ Pittock SJ, Weinshenker BG, Lucchinetti CF, Wingerchuk DM, Corboy JR, Lennon VA (2006). "Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression". Archives of Neurology. 63 (7): 964–968. doi:10.1001/archneur.63.7.964. PMID 16831965.
- ↑ Pranzatelli MR, Travelstead AL, Tate ED, Allison TJ, Moticka EJ, Franz DN, Nigro MA, Parke JT, Stumpf DA, Verhulst SJ (2004). "B- and T-cell markers in opsoclonus-myoclonus syndrome: Immunophenotyping of CSF lymphocytes". Neurology. 62 (9): 1526–1532. doi:10.1212/WNL.62.9.1526. PMID 15136676. S2CID 71988257.
- ↑ "Autoimmune Inner Ear Disease, Baylor College of Medicine". 1993. Archived from the original on 2008-05-17.
- ↑ Boulassel MR, Deggouj N, Tomasi JP, Gersdorff M (January 2001). "Inner ear autoantibodies and their targets in patients with autoimmune inner ear diseases". Acta Oto-Laryngologica. 121 (1): 28–34. doi:10.1080/000164801300006236. PMID 11270490.
- 1 2 3 J. C. Jennette; R. J. Falk; P. A. Bacon; et al. (January 2013). "2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides". Arthritis & Rheumatism. 65 (1): 1–11. doi:10.1002/art.37715. PMID 23045170.
- ↑ "Possible Source of Kawasaki Disease Found".
- ↑ Wisnieski JJ, Naff GB (September 1989). "Serum IgG antibodies to C1q in hypocomplementemic urticarial vasculitis syndrome". Arthritis & Rheumatology. 32 (9): 1119–27. doi:10.1002/anr.1780320910. PMID 2528353.
- ↑ Dispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson DR, Greipp PR, Witzig TE, Basu R, Suarez GA, Fonseca R, Lust JA, Gertz MA (2003). "POEMS syndrome: definitions and long-term outcome". Blood. 101 (7): 2496–506. doi:10.1182/blood-2002-07-2299. PMID 12456500.
- ↑ Lim, Megan S.; Elenitoba-Johnson, Kojo S.J. (May 2004). "The Molecular Pathology of Primary Immunodeficiencies". The Journal of Molecular Diagnostics. 6 (2): 59–83. doi:10.1016/S1525-1578(10)60493-X. PMC 1867474. PMID 15096561.
- ↑ Hyland KV, Engman DM (2006). "Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease". Trends in Parasitology. 22 (3): 101–2, author reply 103. doi:10.1016/j.pt.2006.01.001. PMID 16446117.
- ↑ Agustí A, MacNee W, Donaldson K, Cosio M (2003). "Hypothesis: does COPD have an autoimmune component?". Thorax. 58 (10): 832–834. doi:10.1136/thorax.58.10.832. PMC 1746486. PMID 14514931.
- ↑ Lee SH, Goswami S, Grudo A, Song LZ, Bandi V, Goodnight-White S, Green L, Hacken-Bitar J, Huh J, Bakaeen F, Coxson HO, Cogswell S, Storness-Bliss C, Corry DB, Kheradmand F (2007). "Antielastin autoimmunity in tobacco smoking-induced emphysema". Nature Medicine. 13 (5): 567–9. doi:10.1038/nm1583. PMID 17450149. S2CID 1732877.
- ↑ Blauwet, Lori A.; Cooper, Leslie T. (31 October 2012). "Idiopathic giant cell myocarditis and cardiac sarcoidosis". Heart Failure Reviews. 18 (6): 733–746. doi:10.1007/s10741-012-9358-3. PMID 23111533. S2CID 21558135.
- ↑ Online Mendelian Inheritance in Man (OMIM): 178500
- ↑ van der Vliet, Hans J. J.; Nieuwenhuis, Edward E. (2007). "IPEX as a Result of Mutations in FOXP3". Clinical and Developmental Immunology. 2007: 89017. doi:10.1155/2007/89017. PMC 2248278. PMID 18317533.
- ↑ Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SC, Hong SS, Honda Y, Honda M, Högl B, Longstreth WT, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poli F, Frauscher B, Jeong JH, Lee SP, Ton TG, Kvale M, Kolesar L, Dobrovolná M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok PY, Risch N, Mignot E (June 2009). "Narcolepsy is strongly associated with the TCR alpha locus". Nature Genetics. 41 (6): 708–11. doi:10.1038/ng.372. PMC 2803042. PMID 19412176.
- ↑ "Narcolepsy is an autoimmune disorder, Stanford researcher says". EurekAlert. American Association for the Advancement of Science. 2009-05-03. Archived from the original on 10 May 2009. Retrieved 2009-05-31.
- ↑ Mignot E (2001). "A commentary on the neurobiology of the hypocretin/orexin system". Neuropsychopharmacology. 25 (5 Suppl): S5–13. doi:10.1016/S0893-133X(01)00316-5. PMID 11682267.
- ↑ Maret S, Tafti M (November 2005). "Genetics of narcolepsy and other major sleep disorders" (PDF). Swiss Medical Weekly. 135 (45–46): 662–5. PMID 16453205. Archived (PDF) from the original on 14 April 2008. Retrieved 2008-03-07.
- ↑ Eaton WW, Byrne M, Ewald H, Mors O, Chen CY, Agerbo E, Mortensen PB (2006). "Association of schizophrenia and autoimmune diseases: linkage of Danish national registers". American Journal of Psychiatry. 163 (3): 521–8. doi:10.1176/appi.ajp.163.3.521. PMID 16513876.
- ↑ Jones AL, Mowry BJ, Pender MP, Greer JM (2005). "Immune dysregulation and self-reactivity in schizophrenia: do some cases of schizophrenia have an autoimmune basis?" (PDF). Immunology and Cell Biology. 83 (1): 9–17. doi:10.1111/j.1440-1711.2005.01305.x. PMID 15661036. S2CID 23236916.
- ↑ Strous RD, Shoenfeld Y (2006). "Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited". Journal of Autoimmunity. 27 (2): 71–80. doi:10.1016/j.jaut.2006.07.006. PMID 16997531.
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