Phaclofen

Phaclofen
Names
	IUPAC name [3-amino-2-(4-chlorophenyl)propyl]phosphonic acid
Identifiers
CAS Number	108351-35-5 ;
3D model (JSmol)	Interactive image;
ChemSpider	1579 ;
IUPHAR/BPS	1091;
PubChem CID	1641;
	InChI InChI=1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14) Key: VSGNGLJPOGUDON-UHFFFAOYSA-N ; InChI=1/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14) Key: VSGNGLJPOGUDON-UHFFFAOYAO;
	SMILES C1=CC(=CC=C1C(CN)CP(=O)(O)O)Cl;
Properties
Chemical formula	C9H13ClNO3P
Molar mass	249.631 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Phaclofen, or phosphonobaclofen, is a selective antagonist for the GABA_B receptor.^[1] It was the first selective GABA_B antagonist discovered, but its utility was limited by the fact that it does not cross the blood brain barrier.^[2]

References

↑ David I.B. KerrCorresponding author contact information, Jennifer Ong, Rolf H. Prager, Bruce D. Gynther, David R. Curtis (3 March 1987). "Phaclofen: a peripheral and central baclofen antagonist". Brain Research. 405: 150–154. doi:10.1016/0006-8993(87)90999-1. {{cite journal}}: |author= has generic name (help)CS1 maint: multiple names: authors list (link)
↑ Froestl W, Mickel SJ, von Sprecher G, Diel PJ, Hall RG, Maier L, Strub D, Melillo V, Baumann PA, Bernasconi R, et al. (August 18, 1995). "Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists". J Med Chem. 38 (17): 3313-31. doi:10.1021/jm00017a016. PMID 7650685.

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[1] David I.B. KerrCorresponding author contact information, Jennifer Ong, Rolf H. Prager, Bruce D. Gynther, David R. Curtis (3 March 1987). "Phaclofen: a peripheral and central baclofen antagonist". Brain Research. 405: 150–154. doi:10.1016/0006-8993(87)90999-1. {{cite journal}}: |author= has generic name (help)CS1 maint: multiple names: authors list (link)

[2] Froestl W, Mickel SJ, von Sprecher G, Diel PJ, Hall RG, Maier L, Strub D, Melillo V, Baumann PA, Bernasconi R, et al. (August 18, 1995). "Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists". J Med Chem. 38 (17): 3313-31. doi:10.1021/jm00017a016. PMID 7650685.

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