Ro 6-3129

Ro 6-3129
Clinical data
Other names16α-Ethylthiodydrogesterone; 16α-Ethylthio-6-dehydroretroprogesterone; 16α-Ethylthio-9β,10α-pregna-4,6-diene-3,20-dione
Routes of
administration		Oral
Identifiers
IUPAC name
  • (1R,2S,10S,11S,13R,14S,15S)-14-Acetyl-13-(ethylsulfanyl)-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-6,8-dien-5-one
ChemSpider
Chemical and physical data
FormulaC23H32O2S
Molar mass372.57 g·mol−1
3D model (JSmol)
SMILES
  • CCS[C@@H]1C[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]2(C)[C@H]1C(C)=O
InChI
  • InChI=1S/C23H32O2S/c1-5-26-20-13-19-17-7-6-15-12-16(25)8-10-22(15,3)18(17)9-11-23(19,4)21(20)14(2)24/h6-7,12,17-21H,5,8-11,13H2,1-4H3/t17-,18-,19+,20-,21+,22-,23?/m1/s1
  • Key:OWNPEOXTHUGQDI-LWAHLCLDSA-N

Ro 6-3129, also known as 16α-ethylthio-6-dehydroretroprogesterone or as 16α-ethylthio-9β,10α-pregna-4,6-diene-3,20-dione, as well as 16α-ethylthiodydrogesterone, is a progestogen of the retroprogesterone group which was developed by Roche but was never marketed.[1][2][3] It shows greater potency than dydrogesterone in bioassays.[4]

References

  1. ↑ JUCKER (8 March 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des rechersches pharmaceutiques. Birkhäuser. pp. 321–. ISBN 978-3-0348-7098-6.
  2. ↑ Larsson-Cohn U, Johansson ED, Wide L, Gemzell C (1970). "Effects of daily administration of a retrosteroid on the plasma levels of progesterone and on the urinary excretion of luteinizing hormone and total oestrogens". J Obstet Gynaecol Br Commonw. 77 (9): 840–6. doi:10.1111/j.1471-0528.1970.tb04411.x. PMID 5458777. S2CID 6176278.
  3. ↑ Dixon, Ross; Hudson, Sean; Darragh, Austin (1973). "Pharmacokinetics of the retro-steroid progestogen, 16α-ethylthio-9β,10α-pregna-4, 6-diene-3, 20-dione (Ro 6-3129), in man and the sheep". Contraception. 8 (1): 53–65. doi:10.1016/0010-7824(73)90159-5. ISSN 0010-7824.
  4. ↑ The Journal of Obstetrics and Gynaecology of the British Commonwealth. Royal College of Obstetricians and Gynaecologists. 1970.



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