HLA-B73

HLA-B73 (B73) is an HLA-B serotype. The serotype identifies the HLA-B*7301 gene product.[1] Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes.[2] B73 is more common in Western Indian Ocean, Mediterranean and Africa. (For terminology help see: HLA-serotype tutorial)

major histocompatibility complex (human), class I, B73
Alleles B*7301
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*7301
Locus chr.6 6p21.31

Serotype

B*73:01 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*18:06, B*46:01, and B*55:03.[3]

B73 serotype recognition of B*7301 allele-group gene products[4]
B*73B73 OtherSample
allele % %size (N)
73012269106

B*7301 frequencies
HLA B*7301 frequencies
freq
ref.Population(%)
[5]Parsi (Karachi, Pakistan)4.9
[5]United Arab Emirates2.0
[5]Italy2.0
[5]Seri (Sonora, Mexico)1.5
[5]Purépecha (Michoacán, Mexico)1.5
[5]Jews (Israel) (*2 studies)1.2
[5]Beti (Cameroon)1.1
[5]Casablanca (Morocco)0.9
[5]Tbilisi (Georgia)0.9
[5]Mossi (Burkina Faso)0.9
[5]Bulgaria0.9
[5]Sudanese0.8
[5]Tuva (Russia) (2)0.8
[5]Oman0.8
[5]Bamileke (Cameroon)0.6
[5]Pathan (Pakistan)0.5
[5]Khalkha (Mongolia)0.5
[5]Druse Arabs (Israel)0.5
[5]Baloch (Iran)0.5
[5]Manchester (England)0.5
[5]Algeria (1)0.5
[5]Turkey0.4
[5]Amman (Jordan)0.3
[5]Shona (Harare, Zimbabwe)0.2
[5]Republic of Macedonia0.2
[5]Nandi (Kenya)0.2
[5]Luo (Kenya)0.2
[5]Campania (Italy)0.2
[5]Greece0.2

References
  1. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. Hoffmann HJ, Kristensen TJ, Jensen TG, Graugaard B, Lamm LU (1995). "Antigenic characteristics and cDNA sequences of HLA-B73". Eur. J. Immunogenet. 22 (3): 231–40. doi:10.1111/j.1744-313X.1995.tb00237.x. PMID 8547229.
  3. Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID 11098937.
  4. derived from IMGT/HLA
  5. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)
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