List of investigational antipsychotics
This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Receptor modulators
Monoamine receptor modulators
- ATI-9242 – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)[1]
- AVN-211 (CD-008-0173) – 5-HT6 receptor antagonist[2]
- Brilaroxazine (RP-5063, RP-5000; oxaripiprazole) – atypical antipsychotic (D2 receptor partial agonist, 5-HT2A receptor antagonist, other actions)[3]
- F-17464 – D3 receptor antagonist, 5-HT1A receptor partial agonist, and weak D2 receptor partial agonist[4]
- FKF-02SC (TGOF-02N) – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)[5]
- Lu-AF35700 – D1, 5-HT2A, and 5-HT6 receptor antagonist[6]
- Masupirdine (SUVN-502) – 5-HT6 receptor antagonist[7]
- Ralmitaront (RG-7906, RO-6889450) – TAAR1 agonist[8]
- Ulotaront (SEP-856, SEP-363856) – 5-HT1A receptor and TAAR1 agonist[9]
- SUVN-D4010 – 5-HT4 receptor partial agonist[10]
- TAK-058 (ENV-8058) – 5-HT3 receptor antagonist[11]
Glutamate receptor modulators
- Neboglamine (CR-2249, XY-2401; nebostinel) – NMDA receptor glycine-site positive allosteric modulator[12]
- PF-4958242 – AMPA receptor positive allosteric modulator[13]
- Pomaglumetad methionil (DB-103, LY-2140023, LY-2812223) – mGluR2 and mGluR3 agonist[14]
Acetylcholine receptor modulators
- APN-1125 – α7 nicotinic acetylcholine receptor partial agonist[15]
- KarXT (xanomeline/trospium) – combined M1 and M4 muscarinic acetylcholine receptor agonist and peripherally-selective muscarinic acetylcholine receptor antagonist[16]
Cannabinoid receptor modulators
- AX-1604 – cannabinoid receptor modulator (phytocannabinoid-based chewing gum)[17]
- Cannabidiol (CBD; GW-42003, GWP-42003, GWP-42003-P, ECP-012A; Arvisol, Epidiolex) – cannabinoid receptor modulator, antioxidant, other actions[18][19]
Other/mixed receptor modulators
- Basmisanil (RG-1662, RO-5186582) – GABAA receptor α5 subunit-containing negative allosteric modulator[20]
- Deudextromethorphan (d-DM; AVP-786, CTP-786) – σ1 receptor agonist, serotonin–norepinephrine reuptake inhibitor, uncompetitive NMDA receptor antagonist, muscarinic acetylcholine receptor agonist, other actions[21][22]
- Erteberel (LY-500307, SERBA-1) – ERβ agonist[23]
- Roluperidone (CYR-101, MIN-101, MT-210) – 5-HT2A and σ2 receptor antagonist[24]
- TAK-041 – GPR139 receptor agonist[25]
Enzyme inhibitors
- BI-409306 (SUB-166499) – phosphodiesterase 9A inhibitor[26]
- Lu-AF11167 – dual phosphodiesterase 2A and 10A inhibitor[27]
- OMS-824 (OMS-643762) – phosphodiesterase 10A inhibitor[28]
- Sodium benzoate (SND-11, SND-12, SND-13, SND-14; Clozaben, NaBen) – D-amino acid oxidase inhibitor[29]
- TAK-831 – D-amino acid oxidase inhibitor[30]
Ion channel modulators
- AUT-00206 – shaw potassium channel modulator[31]
- Evenamide (NW-3509; NW-3509A) – Nav1.3, Nav1.7, and Nav1.8 voltage-gated sodium channel blocker[32]
Others
- ADE-615 – undefined mechanism of action[33]
- ADE-616 – undefined mechanism of action[34]
- AMG-581 – undefined mechanism of action[35]
- ASP-4345 – undefined mechanism of action[36]
- ASP-6981 – undefined mechanism of action[37]
- ATx11-004 – undefined mechanism of action[38]
- MK-8189 – undefined mechanism of action[39]
- PF-06266047 – undefined mechanism of action[40]
- Pyridoxamine (BST-4001, K-163, K-163SZ; Pyridorin) – vitamin B6 analog, advanced glycosylation end-product inhibitor, free radical scavenger[41]
- TS-134 (TS-1341) – undefined mechanism of action[42]
See also
References
- "ATI 9242 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "AVN 211 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Brilaroxazine - Reviva Biopharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "F 17464 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "FKF 02SC - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Lu AF35700 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Masupirdine - Suven Life Sciences - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Ralmitaront - AdisInsight". adisinsight.springer.com. Springer. Retrieved 10 July 2021.
- "SEP 363856 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "SUVN D4010 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "TAK 058 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Neboglamine - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "BIIB 104 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Pomaglumetad methionil - Denovo Biopharma/Eli Lilly and Company - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "APN 1125 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "APN 1125 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "AX 1604 - Axim Biotech - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Cannabidiol - GW Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Cannabidiol - Echo Pharmaceuticals - AdisInsight". adisinsight.springer.com. Retrieved 14 February 2020.
- "Basmisanil - Roche - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Deudextromethorphan - Avanir Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- Nguyen, Linda; Thomas, Kelan L.; Lucke-Wold, Brandon P.; Cavendish, John Z.; Crowe, Molly S.; Matsumoto, Rae R. (March 2016). "Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders". Pharmacology & Therapeutics. 159: 1–22. doi:10.1016/j.pharmthera.2016.01.016. ISSN 1879-016X. PMID 26826604.
- "Erteberel - Eli Lilly and Company - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Roluperidone - Minerva Neurosciences - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- Dao, Maria; Stoveken, Hannah M.; Cao, Yan; Martemyanov, Kirill A. (Jan 21, 2021). "The role of orphan receptor GPR139 in neuropsychiatric behavior". Neuropsychopharmacology. 47: 902–913. doi:10.1038/s41386-021-00962-2. Retrieved 5 August 2022.
- "BI 409306 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Lu AF11167 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "OMS 824 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Sodium benzoate - SyneuRx - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "TAK 831 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "AUT 00206 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Evenamide - Newron Pharmaceuticals - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "ADE 615 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "ADE 616 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "AMG 581 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "ASP 4345 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "ASP 6981 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Atx11 004 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "MK 8189 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "PF 06266047 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "Pyridoxamine - NephroGenex/Kowa - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
- "TS 134 - AdisInsight". adisinsight.springer.com. Springer. Retrieved 14 February 2020.
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