CYP26A1
CYP26A1 (Cytochrome P450 family 26 subfamily A member 1) هوَ بروتين يُشَفر بواسطة جين CYP26A1 في الإنسان.[1][2][3]
الوظيفة
المراجع
- "cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450"، The Journal of Biological Chemistry، 272 (30): 18538–41، يوليو 1997، doi:10.1074/jbc.272.30.18538، PMID 9228017.
- "P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3"، Genomics، 48 (2): 270–2، مارس 1998، doi:10.1006/geno.1997.5157، PMID 9521883.
- "Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1"، مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
- "Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid"، The Journal of Investigative Dermatology، 106 (2): 316–20، فبراير 1996، doi:10.1111/1523-1747.ep12342972، PMID 8601734.
- "CYP26, a novel mammalian cytochrome P450, is induced by retinoic acid and defines a new family"، The Journal of Biological Chemistry، 272 (30): 18702–8، يوليو 1997، doi:10.1074/jbc.272.30.18702، PMID 9228041.
- "Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells"، Cell Growth & Differentiation، 9 (8): 629–37، أغسطس 1998، PMID 9716180.
- "Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues"، Biochemical and Biophysical Research Communications، 252 (2): 487–91، نوفمبر 1998، doi:10.1006/bbrc.1998.9659، PMID 9826557.
- "Cytochrome P450, CYP26AI, is expressed at low levels in human epidermal keratinocytes and is not retinoic acid-inducible"، The British Journal of Dermatology، 141 (3): 460–8، سبتمبر 1999، doi:10.1046/j.1365-2133.1999.03039.x، PMID 10583049.
- "Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation"، Biochemical Pharmacology، 60 (4): 517–26، أغسطس 2000، doi:10.1016/S0006-2952(00)00356-7، PMID 10874126.
- "Cytochrome P450RAI(CYP26) promoter: a distinct composite retinoic acid response element underlies the complex regulation of retinoic acid metabolism"، Molecular Endocrinology، 14 (9): 1483–97، سبتمبر 2000، doi:10.1210/me.14.9.1483، PMID 10976925.
- "Coordinate regulation of the production and signaling of retinoic acid by estrogen in the human endometrium"، The Journal of Clinical Endocrinology and Metabolism، 88 (5): 2157–63، مايو 2003، doi:10.1210/jc.2002-021844، PMID 12727970.
- "The effect of cellular retinoic acid binding protein-I expression on the CYP26-mediated catabolism of all-trans retinoic acid and cell proliferation in head and neck squamous cell carcinoma"، Metabolism، 53 (8): 1007–12، أغسطس 2004، doi:10.1016/j.metabol.2003.12.015، PMID 15281009.
- "Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility"، The Biochemical Journal، 392 (Pt 1): 241–8، نوفمبر 2005، doi:10.1042/BJ20050874، PMC 1317683، PMID 16053444.
- "Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells"، Leukemia & Lymphoma، 46 (10): 1497–506، أكتوبر 2005، doi:10.1080/10428190500174737، PMID 16194896.
- "Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models"، The Journal of Investigative Dermatology، 126 (11): 2473–80، نوفمبر 2006، doi:10.1038/sj.jid.5700432، PMID 16778795.
- "Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida"، Birth Defects Research. Part A, Clinical and Molecular Teratology، 76 (6): 491–8، يونيو 2006، doi:10.1002/bdra.20275، PMID 16933217.
- "Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding"، Journal of Enzyme Inhibition and Medicinal Chemistry، 21 (4): 361–9، أغسطس 2006، doi:10.1080/14756360600742014، PMID 17059167.
- "Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity"، Blood، 109 (10): 4450–60، مايو 2007، doi:10.1182/blood-2006-10-051086، PMID 17218384.
- "The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system"، Pharmacogenetics and Genomics، 17 (3): 169–80، مارس 2007، doi:10.1097/FPC.0b013e32801152d6، PMC 2393551، PMID 17460545.
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