ITIH2

ITIH2
المعرفات
الأسماء المستعارة	ITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 146640 MGI: MGI:96619 HomoloGene: 1668 GeneCards: 3698
علم الوجود الجيني
الوظيفة الجزيئية	• peptidase inhibitor activity; • endopeptidase inhibitor activity; • serine-type endopeptidase inhibitor activity;
المكونات الخلوية	• blood microparticle; • حويصلة خارج خلوية; • منطقة خارج الخلية; • endoplasmic reticulum lumen; • collagen-containing extracellular matrix;
العمليات الحيوية	• hyaluronan metabolic process; • negative regulation of peptidase activity; • negative regulation of endopeptidase activity; • تعديل ما بعد الترجمة;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P19823
	Q61703
	NM_002216
	NM_010582
	NP_002207
	NP_034712
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

ITIH2‏ (Inter-alpha-trypsin inhibitor heavy chain 2) هوَ بروتين يُشَفر بواسطة جين ITIH2 في الإنسان.[1][2][3]

المراجع

"Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2"، مؤرشف من الأصل في 05 ديسمبر 2010.
"The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?"، FEBS Lett، 446 (1): 6–8، مايو 1999، doi:10.1016/S0014-5793(99)00173-8، PMID 10100603.
"Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily"، Genomics، 14 (1): 83–8، ديسمبر 1992، doi:10.1016/S0888-7543(05)80287-3، PMID 1385302.

قراءة متعمقة

"The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A."، Biol. Chem. Hoppe-Seyler، 373 (10): 1009–18، 1992، doi:10.1515/bchm3.1992.373.2.1009، PMID 1384548.
"Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI."، Proc. Natl. Acad. Sci. U.S.A.، 84 (23): 8272–6، 1988، doi:10.1073/pnas.84.23.8272، PMC 299524، PMID 2446322.
"Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex."، FEBS Lett.، 229 (1): 63–7، 1988، doi:10.1016/0014-5793(88)80798-1، PMID 2450046.
"Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain."، Biol. Chem. Hoppe-Seyler، 369 Suppl: 15–8، 1989، PMID 2462430.
"Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes."، Eur. J. Biochem.، 179 (1): 147–54، 1989، doi:10.1111/j.1432-1033.1989.tb14532.x، PMID 2465147.
"Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan."، J. Biol. Chem.، 264 (27): 15975–81، 1989، PMID 2476436.
"cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins."، Biol. Chem. Hoppe-Seyler، 368 (8): 963–70، 1987، doi:10.1515/bchm3.1987.368.2.963، PMID 3663330.
"A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor."، J. Biol. Chem.، 268 (35): 26725–30، 1994، PMID 7504674.
"Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor."، Eur. J. Biochem.، 221 (2): 881–8، 1994، doi:10.1111/j.1432-1033.1994.tb18803.x، PMID 7513643.
"TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor."، Biochemistry، 33 (23): 7423–9، 1994، doi:10.1021/bi00189a049، PMID 7516184.
"Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin."، J. Biol. Chem.، 268 (12): 8711–6، 1993، PMID 7682553.
"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides"، Gene، 138 (1–2): 171–4، 1994، doi:10.1016/0378-1119(94)90802-8، PMID 8125298.
"Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains."، J. Immunol. Methods، 190 (1): 61–70، 1996، doi:10.1016/0022-1759(95)00257-X، PMID 8601712.
"Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library"، Gene، 200 (1–2): 149–56، 1997، doi:10.1016/S0378-1119(97)00411-3، PMID 9373149.
"Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2."، Biochemistry، 37 (1): 408–16، 1998، doi:10.1021/bi971137d، PMID 9425062.
"Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues."، Biol. Pharm. Bull.، 21 (2): 167–9، 1998، doi:10.1248/bpb.21.167، PMID 9514613.
"Glycosylation pattern of human inter-alpha-inhibitor heavy chains."، Biochem. J.، 333 (3): 749–56، 1998، PMC 1219641، PMID 9677337.
"Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis."، BMC Cancer، 8 (25): 25، 2008، doi:10.1186/1471-2407-8-25، PMC 2268946، PMID 18226209.

بوابة طب
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي

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[entrez-1] "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2"، مؤرشف من الأصل في 05 ديسمبر 2010.

[pmid10100603-2] "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?"، FEBS Lett، 446 (1): 6–8، مايو 1999، doi:10.1016/S0014-5793(99)00173-8، PMID 10100603.

[pmid1385302-3] "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily"، Genomics، 14 (1): 83–8، ديسمبر 1992، doi:10.1016/S0888-7543(05)80287-3، PMID 1385302.

التصنيفات الطبية	OMIM ID: 146640
المعرفات الخارجية	Ensembl Transcript ID: ENST00000358415, ENST00000379587, ENST00000429820, ENST00000473227, ENST00000477751, ENST00000480387