PSB-CB5

PSB-CB5 (CID-85469571) is a compound which acts as an antagonist at the former orphan receptor GPR18, and is the first selective antagonist characterised for this receptor, with an IC50 of 279nM, and good selectivity over related receptors (over 36x selectivity vs CB1 and GPR55, and 14x vs CB2.) As all previously known antagonists for GPR18 also antagonise GPR55, it has been difficult to separate the effects of these two receptor targets, so the discovery of a selective GPR18 antagonist is expected to be useful in research into the actions of this receptor.[1][2][3]

PSB-CB5
Identifiers
IUPAC name
  • (2Z)-2-[(3-[(4-chlorophenyl)methoxy]phenyl)methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC20H17ClN2O2S
Molar mass384.879 g·mol−1
3D model (JSmol)
SMILES
  • Clc4ccc(cc4)COc(c2)cccc2\C=C(\C1=O)/N=C3N1CCCS3
InChI
  • InChI=1S/C20H17ClN2O2S/c21-16-7-5-14(6-8-16)13-25-17-4-1-3-15(11-17)12-18-19(24)23-9-2-10-26-20(23)22-18/h1,3-8,11-12H,2,9-10,13H2/b18-12-
  • Key:XJBQRMOGMULGPP-PDGQHHTCSA-N

See also

References
  1. Rempel V, Atzler K, Behrenswerth A, Karcz T, Schoeder C, Hinz S, et al. (2014). "Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55". MedChemComm. 5 (5): 632–49. doi:10.1039/C3MD00394A.
  2. Flegel C, Vogel F, Hofreuter A, Wojcik S, Schoeder C, Kieć-Kononowicz K, et al. (August 2016). "Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18". Scientific Reports. 6: 32255. Bibcode:2016NatSR...632255F. doi:10.1038/srep32255. PMC 5004183. PMID 27572937.
  3. Schoeder CT, Kaleta M, Mahardhika AB, Olejarz-Maciej A, Łażewska D, Kieć-Kononowicz K, Müller CE (July 2018). "Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18". European Journal of Medicinal Chemistry. 155: 381–397. doi:10.1016/j.ejmech.2018.05.050. PMID 29902723.
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