Glycopyrronium bromide/formoterol

Glycopyrronium bromide/formoterol
Combination of
Glycopyrronium bromideMuscarinic anticholinergic
FormoterolLong-acting β2 agonist (LABA)
Clinical data
Trade namesBevespi Aerosphere
AHFS/Drugs.comMonograph
License data
Routes of
administration		By mouth (inhalation)
ATC code
Legal status
Legal status
  • US: ℞-only [1]
  • EU: Rx-only [2]
  • In general: ℞ (Prescription only)
Identifiers
KEGG

Glycopyrronium bromide/formoterol, sold under the brand name Bevespi Aerosphere, is a combination medication for the maintenance treatment of chronic obstructive pulmonary disease (COPD).[1][2] It is a combination of glycopyrronium bromide and formoterol. It is inhaled.[1][2]

The most common side effects include headache, nausea (feeling sick), muscle spasms and dizziness.[2]

Glycopyrronium bromide is a muscarinic receptor antagonist.[2] This means that it blocks muscarinic receptors (targets) in muscle cells in the lungs.[2] Because these receptors help control the contraction of muscles, when glycopyrronium is inhaled, it causes the muscles of the airways to relax, helping to keep the airways open.[2]

Formoterol is a long-acting beta-2 agonist.[2] It works by attaching to receptors known as beta-2 receptors found in the muscles of the airways.[2] When it attaches to these receptors, it causes the muscles to relax, which keeps the airways open.[2]

Medical uses

Glycopyrronium bromide/formoterol is indicated as a maintenance bronchodilator treatment to relieve symptoms in adults with chronic obstructive pulmonary disease (COPD).[2]

History

Glycopyrronium bromide/formoterol was approved for medical use in the United States in April 2016,[3] and in the European Union in December 2018.[2]

It is marketed by AstraZeneca.[1][2]

References

  1. 1 2 3 4 "Bevespi Aerosphere- glycopyrrolate and formoterol fumarate aerosol, metered". DailyMed. 29 May 2019. Retrieved 8 May 2020.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 "Bevespi Aerosphere EPAR". European Medicines Agency (EMA). 18 October 2018. Retrieved 8 May 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  3. ↑ "Bevespi Aerosphere (glycopyrrolate and formoterol fumarate) Inhalation Aerosol". U.S. Food and Drug Administration (FDA). 16 February 2018. Retrieved 8 May 2020.

Further reading

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