Arformoterol

Arformoterol
Names
Trade namesBrovana
Other namesArformoterol tartrate
IUPAC name
  • N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl) propan-2-yl]amino]ethyl] phenyl]formamide
Clinical data
Drug classLABA[1]
Main usesCOPD[1]
Side effectsDiarrhea, sinusitis, rash, peripheral swelling, chest pain[1]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Routes of
use		Inhalation solution for nebuliser
External links
AHFS/Drugs.comMonograph
MedlinePlusa602023
Legal
License data
Legal status
Pharmacokinetics
Protein binding52–65%
Elimination half-life26 hours
Chemical and physical data
FormulaC19H24N2O4
Molar mass344.411 g·mol−1
InChI
  • InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1 checkY
  • Key:BPZSYCZIITTYBL-YJYMSZOUSA-N checkY

Arformoterol, sold under the brand name Brovana, is a medication used for the long-term treat chronic obstructive pulmonary disease (COPD).[1] It is not indicated for sudden worsening.[2] It is given by nebulization.[1] Maximum effect may take 3 hours.[1]

Common side effects include diarrhea, sinusitis, rash, peripheral swelling, and chest pain.[1] Other side effect ma include low potassium, anaphylaxis, and bronchospasm.[1] Safety in pregnancy is unclear.[1] It is a long-acting β2 adrenoreceptor agonist (LABA).[1] It is the active component of formoterol.[1]

Arformoterol was approved for medical use in the United States in 2006.[1] It is available as a generic medication.[3] In the United States a month of medication costs about 240 USD as of 2022.[3]

Medical uses

Dosage

It is typically used at a dose of 15 micrograms twice per day.[1]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 "Arformoterol Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 16 January 2022.
  2. ↑ "DailyMed - ARFORMOTEROL TARTRATE solution". dailymed.nlm.nih.gov. Archived from the original on 16 January 2022. Retrieved 16 January 2022.
  3. 1 2 "Arformoterol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 August 2016. Retrieved 16 January 2022.
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