Malassezia

Malassezia
Malassezia furfur in skin scale from a patient with tinea versicolor
Scientific classification
Kingdom: Fungi
Division: Basidiomycota
Class: Malasseziomycetes
Denchev & T.Denchev (2014)
Order: Malasseziales
R.T.Moore (1980)
Family: Malasseziaceae
Denchev & R.T.Moore (2009)
Genus: Malassezia
Baill. (1889)[1]
Type species
Malassezia furfur
(C.P.Robin) Baill. (1889)
Synonyms[2]
  • Pityrosporum Sabour. (1904)

Malassezia (formerly known as Pityrosporum) is a genus of fungi. It is the sole genus in family Malasseziaceae, which is the only family in order Malasseziales, itself the single member of class Malasseziomycetes.[3] Malassezia species are naturally found on the skin surfaces of many animals, including humans. In occasional opportunistic infections, some species can cause hypopigmentation or hyperpigmentation on the trunk and other locations in humans. Allergy tests for these fungi are available.

Systematics

A 25-year-old man with pityrosporum folliculitis and electron micrograph of his skin, showing Malassezia spores.[4]

Due to progressive changes in their nomenclature, some confusion exists about the naming and classification of Malassezia yeast species. Work on these yeasts has been complicated because they require specific growth media and grow very slowly in laboratory culture.[5]

Malassezia were originally identified by the French scientist Louis-Charles Malassez in the late nineteenth century. Raymond Sabouraud identified a dandruff-causing organism in 1904 and called it "Pityrosporum malassez", honoring Malassez, but at the species level as opposed to the genus level. When it was determined that the organisms were the same, the term "Malassezia" was judged to possess priority.[6]

In the mid-twentieth century, it was reclassified into two species:

  • Pityrosporum (Malassezia) ovale, which is lipid-dependent and found only on humans. P. ovale was later divided into two species, P. ovale and P. orbiculare, but current sources consider these terms to refer to a single species of fungus, with M. furfur the preferred name.[7]
  • Pityrosporum (Malassezia) pachydermatis, which is lipophilic but not lipid-dependent. It is found on the skin of most animals.

In the mid-1990s, scientists at the Pasteur Institute in Paris, France, discovered additional species.[8]

Malassezia is the sole genus in the family Malasseziaceae, which was validated by Cvetomir Denchev and Royall T. Moore in 2009.[9] The order Malasseziales had been previously proposed by Moore in 1980,[10] and later emended by Begerow and colleagues in 2000. At this time the order was classified as a member of unknown class placement in the subdivision Ustilaginomycotina.[11] In 2014, Cvetomir and Teodor Denchev circumscribed the class Malasseziomycetes to contain the group.[12]

Species

As of April 2021, Species Fungorum accepts 22 species of Malassezia.[13] The following list gives the name of the fungus, the taxonomic authority (those who first described the fungus, or who transferred it into Malassezia from another genus; standardized author abbreviations are used), and the name of the organism from which the fungus was isolated, if not human.

  • Malassezia arunalokei Honnavar, Rudramurthy, G.S.Prasad & Chakrabarti[14]
  • Malassezia brasiliensis F.J.Cabañes, S.D.A.Coutinho, M.R.Bragulat & G.Castellá[15] – from lesions on the beak of turquoise-fronted amazon parrot
  • Malassezia caprae J.Cabañes & Boekhout[16] – from skin of goat
  • Malassezia cuniculi J.Cabañes & G.Castellá[17] – from healthy skin of external ear canal of rabbit
  • Malassezia dermatis Sugita, M.Takash., A.Nishikawa & Shinoda[18]
  • Malassezia equi Nell, S.A.James, C.J.Bond, B.Hunt & Herrtage[19] – from skin of horse
  • Malassezia equina J.Cabañes & Boekhout[16] – from skin of horse
  • Malassezia furfur (C.P.Robin) Baill.
  • Malassezia globosa Midgley, E.Guého & J.Guillot[20]
  • Malassezia japonica Sugita, M.Takash., M.Kodama, Tsuboi & A.Nishikawa[21]
  • Malassezia muris (Gluge & d'Ukedem ex Guég.) Escomel – skin of mouse
  • Malassezia nana A.Hirai, R.Kano, Makimura, H.Yamag. & A.Haseg.[22] – from discharge from ear of cat
  • Malassezia obtusa Midgley, J.Guillot & E.Guého[23]
  • Malassezia ochoterenai Maecke[24]
  • Malassezia pachydermatis (Weidman) C.W.Dodge[25] – from skin of Indian rhinoceros
  • Malassezia psittaci F.J.Cabañes, S.D.A.Coutinho, M.R.Bragulat & G.Castellá[26] – from lesions on the beak of blue-headed parrot
  • Malassezia restricta E.Guého, J.Guillot & Midgley[27]
  • Malassezia slooffiae J.Guillot, Midgley & E.Guého[28] – from skin of pig
  • Malassezia sympodialis R.B.Simmons & E.Guého[29]
  • Malassezia tropica (Castell.) Schmitter
  • Malassezia vespertilionis J.M.Lorch & Vanderwolf[30] – from vesper bats in subfamily Myotinae
  • Malassezia yamatoensis Sugita, M.Takash., Tajima, Tsuboi & A.Nishikawa[31]

Role in human diseases

Dermatitis and dandruff

Identification of Malassezia on skin has been aided by the application of molecular or DNA-based techniques. These investigations show that the Malassezia species causing most skin disease in humans, including the most common cause of dandruff and seborrhoeic dermatitis, is M. globosa (though M. restricta is also involved).[20] The skin rash of tinea versicolor (pityriasis versicolor) is also due to infection by this fungus.

As the fungus requires fat to grow,[8] it is most common in areas with many sebaceous glands: on the scalp,[32] face, and upper part of the body. When the fungus grows too rapidly, the natural renewal of cells is disturbed, and dandruff appears with itching (a similar process may also occur with other fungi or bacteria so differential diagnosis should be made).

A project in 2007 has sequenced the genome of dandruff-causing Malassezia globosa and found it to have 4,285 genes.[33][34] M. globosa uses eight different types of lipase, along with three phospholipases, to break down the oils on the scalp. Any of these 11 proteins would be a suitable target for dandruff medications.

The number of specimens of M. globosa on a human head can be up to ten million.[32]

M. globosa has been predicted to have the ability to reproduce sexually,[35] but this has not been observed.

Research

Malassezia is among the many mycobiota undergoing laboratory research to investigate whether it is associated with types of disease.[36]

References

  1. Baillon, Henri Ernest (1889). "Traité de botanique médicale cryptogamique" [Treatise on cryptogamic medical botany] (in French). Paris: Octave Doin: 234. doi:10.5962/bhl.title.5409. OCLC 2139870. {{cite journal}}: Cite journal requires |journal= (help)
  2. "Synonymy: Malassezia Baill., Traité Bot. Méd. Crypt.: 234 (1889)". Species Fungorum. Retrieved 2 April 2021.
  3. Wijayawardene, Nalin; Hyde, Kevin; Al-Ani, Laith Khalil Tawfeeq; Somayeh, Dolatabadi; Stadler, Marc; Haelewaters, Danny; et al. (2020). "Outline of Fungi and fungus-like taxa". Mycosphere. 11: 1060–1456. doi:10.5943/mycosphere/11/1/8.
  4. Ran Yuping (2016). "Observation of Fungi, Bacteria, and Parasites in Clinical Skin Samples Using Scanning Electron Microscopy". In Janecek, Milos; Kral, Robert (eds.). Modern Electron Microscopy in Physical and Life Sciences. InTech. doi:10.5772/61850. ISBN 978-953-51-2252-4.
  5. Theelen, Bart; Cafarchia, Claudia; Gaitanis, Georgios; Bassukas, Ioannis Dimitrios; Boekhout, Teun; Dawson, Thomas L. (2018). "Malassezia ecology, pathophysiology, and treatment". Medical Mycology. 56 (suppl 1): S10–S25. doi:10.1093/mmy/myx134. PMID 29538738.
  6. Inamadar AC, Palit A (2003). "The genus Malassezia and human disease". Indian J Dermatol Venereol Leprol. 69 (4): 265–70. PMID 17642908.
  7. Freedberg; et al., eds. (2003). Fitzpatrick's Dermatology in General Medicine (6th ed.). McGraw-Hill. p. 1187. ISBN 0-07-138067-1.
  8. 1 2 Guého E, Midgley G, Guillot J (May 1996). "The genus Malassezia with description of four new species". Antonie van Leeuwenhoek. 69 (4): 337–355. doi:10.1007/BF00399623. PMID 8836432. S2CID 31791799.
  9. Denchev, C.M.; Moore, R.T. (2009). "Validation of Malasseziaceae and Ceraceosoraceae (Exobasidiomycetes)". Mycotaxon. 110: 379–382. doi:10.5248/110.379.
  10. Moore, R.T. (1980). "Taxonomic proposals for the classification of marine yeasts and other yeast-like fungi including the smuts". Botanica Marina. 23 (6): 361–373.
  11. Begerow, Dominik; Bauer, Robert; Boekhout, Teun (2000). "Phylogenetic placements of ustilaginomycetous anamorphs as deduced from nuclear LSU rDNA sequences". Mycological Research. 104 (1): 53–60. doi:10.1017/s0953756299001161.
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  15. Cabañes, F.J.; Coutinho, S.D.A.; Puig, L.; Bragulat, M.R.; Castellá, G. (2016). "New lipid-dependent Malassezia species from parrots". Revista Iberoamericana de Micología. 33 (2): 92–99. doi:10.1016/j.riam.2016.03.003. PMID 27184440.
  16. 1 2 Cabañes, FJ, Theelen, B, Castella, G, Boukhout, T (2007). "Two new lipid-dependent Malassezia species from domestic animals". FEMS Yeast Research. 7 (6): 1064–1076. doi:10.1111/j.1567-1364.2007.00217.x. ISSN 1567-1356. PMID 17367513.
  17. Cabañes FJ, Vega S, Castellá G (2011). "Malassezia cuniculi sp. nov., a novel yeast species isolated from rabbit skin". Medical Mycology. 49 (1): 40–48. doi:10.3109/13693786.2010.493562. PMID 20560865.
  18. Sugita T, Takashima M, Shinoda T, et al. (April 2002). "New Yeast Species, Malassezia dermatis, Isolated from Patients with Atopic Dermatitis". J. Clin. Microbiol. 40 (4): 1363–7. doi:10.1128/JCM.40.4.1363-1367.2002. PMC 140359. PMID 11923357.
  19. White, S.D.; Vandenabeele, S.I.J.; Drazenovich, N.L.; Foley, J.E. (2006). "Malassezia species isolated from the intermammary and preputial fossa areas of horses". Journal of Veterinary Internal Medicine. 20 (2): 395–398. doi:10.1892/0891-6640(2006)20[395:MSIFTI]2.0.CO;2. PMID 16594600.
  20. 1 2 DeAngelis YM, Saunders CW, Johnstone KR, et al. (September 2007). "Isolation and expression of a Malassezia globosa lipase gene, LIP1". J. Invest. Dermatol. 127 (9): 2138–46. doi:10.1038/sj.jid.5700844. PMID 17460728.
  21. Sugita, Takashi; Masako Takashima; Minako Kodama; Ryoji Tsuboi; Akemi Nishikawa (October 2003). "Description of a New Yeast Species, Malassezia japonica, and Its Detection in Patients with Atopic Dermatitis and Healthy Subjects". J. Clin. Microbiol. 41 (10): 4695–4699. doi:10.1128/JCM.41.10.4695-4699.2003. PMC 254348. PMID 14532205.
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  23. Guého, E.; Midgley, G.; Guillot, J. (1996). "The genus Malassezia with description of four new species". Antonie van Leeuwenhoek. 69 (4): 337–355. doi:10.1007/BF00399623. PMID 8836432. S2CID 31791799.
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  31. Sugita T, Tajima M, Takashima M, et al. (2004). "A new yeast, Malassezia yamatoensis, isolated from a patient with seborrheic dermatitis, and its distribution in patients and healthy subjects". Microbiol. Immunol. 48 (8): 579–83. doi:10.1111/j.1348-0421.2004.tb03554.x. PMID 15322337. S2CID 34281815.
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Further reading

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