THCP-O-acetate

THCP-O-acetate (THCP-O) is a semi-synthetic derivative of tetrahydrocannabiphorol (THCP) derived by acetylation of the OH group. It has been found as a component of grey-market cannabis products such as e-cigarette liquids and edible gummy lollies, and is allegedly a potent and long-lasting psychoactive cannabinoid.[1]

THCP-O-acetate
Identifiers
  • (6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-yl acetate
Chemical and physical data
FormulaC25H36O3
Molar mass384.560 g·mol−1
3D model (JSmol)
  • CC(=O)Oc1cc(CCCCCCC)cc2OC(C)(C)[C@@H]3CCC(C)=C[C@H]3c21

Toxicity

In 2022, researchers at Portland State University who screened for the presence of reacted ketene as N-benzylacetamide reported that Vitamin E acetate, CBD-acetate, CBN-acetate and THC-O-acetate may break down to release ketene gas when heated at 340 °C (644 °F).

The lowest concentration of inhaled ketene that produces a physiologically negative response is 5 ppm (5 parts per million).[2] For this reason it is advised to exercise caution around THC-O acetate and other acetate esters of inhaled drugs.

See also

References
  1. Erickson BE (2023). "Waiting for CBD regulations in the US". Chemical & Engineering News. 101 (28): 17–19. doi:10.1021/cen-10128-feature1. S2CID 261318144.
  2. Ketene. National Academies Press (US). 21 March 2014.
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