Vitiligo

Vitiligo
Non-segmental vitiligo of the hand
Pronunciation
  • /ˌvɪtɪˈlaɪɡoʊ/ (About this soundlisten)
SpecialtyDermatology
SymptomsPatches of white skin[1]
Usual onsetChildhood, young adult[1]
DurationLong term[1]
CausesUnknown[2]
Risk factorsFamily history, other autoimmune diseases[3]
Diagnostic methodTissue biopsy[3]
TreatmentSunscreen, makeup, topical corticosteroids, phototherapy[2][3]
Frequency1% of people[4]

Vitiligo is a long-term skin condition characterized by patches of the skin losing their pigment.[1] The patches of skin affected become white and usually have sharp margins.[2] The hair from the skin may also become white.[2] The inside of the mouth and nose may also be involved.[3] Typically both sides of the body are affected.[2] Often the patches begin on areas of skin that are exposed to the sun.[3] It is more noticeable in people with dark skin.[3] Vitiligo may result in psychological stress and those affected may be stigmatized.[2]

The exact cause of vitiligo is unknown.[2] It is believed to be due to genetic susceptibility that is triggered by an environmental factor such that an autoimmune disease occurs.[2][3] This results in the destruction of skin pigment cells.[3] Risk factors include a family history of the condition or other autoimmune diseases, such as hyperthyroidism, alopecia areata, and pernicious anemia.[3] It is not contagious.[5] Vitiligo is classified into two main types: segmental and non-segmental.[2] Most cases are non-segmental, meaning they affect both sides; and in these cases, the affected area of the skin typically expands with time.[2] About 10% of cases are segmental, meaning they mostly involve one side of the body; and in these cases, the affected area of the skin typically does not expand with time.[2] Diagnosis can be confirmed by tissue biopsy.[3]

There is no known cure for vitiligo.[2] For those with light skin, sunscreen and makeup are all that is typically recommended.[2] Other treatment options may include steroid creams or phototherapy to darken the light patches.[3] Alternatively, efforts to lighten the unaffected skin, such as with hydroquinone, may be tried.[3] Several surgical options are available for those who do not improve with other measures.[3] A combination of treatments generally has better outcomes.[4] Counselling to provide emotional support may be useful.[2]

Globally about 1% of people are affected by vitiligo.[4] In some populations it affects as many as 2–3%.[6] Males and females are equally affected.[2] About half show the disorder before age 20 and most develop it before age 40.[2] Vitiligo has been described since ancient history.[2]

Signs and symptoms

The only sign of vitiligo is the presence of pale patchy areas of depigmented skin which tend to occur on the extremities.[7][8] Some people may experience itching before a new patch occurs.[9] The patches are initially small, but often grow and change shape.[7][10] When skin lesions occur, they are most prominent on the face, hands and wrists.[7][8] The loss of skin pigmentation is particularly noticeable around body orifices, such as the mouth, eyes, nostrils, genitalia and umbilicus.[7][8] Some lesions have increased skin pigment around the edges.[11] Those affected by vitiligo who are stigmatized for their condition may experience depression and similar mood disorders.[12]

  • Vitiligo on light skin
    Vitiligo on light skin
  • Non-segmental vitiligo on dark skin, hand facing up
    Non-segmental vitiligo on dark skin, hand facing up
  • Non-segmental vitiligo of the eyelids
    Non-segmental vitiligo of the eyelids

Causes

Although multiple hypotheses have been suggested as potential triggers that cause vitiligo, studies strongly imply that changes in the immune system are responsible for the condition.[2][13] Vitiligo has been proposed to be a multifactorial disease with genetic susceptibility and environmental factors both thought to play a role.[2]

The TYR gene encodes the protein tyrosinase, which is not a component of the immune system, but is an enzyme of the melanocyte that catalyzes melanin biosynthesis, and a major autoantigen in generalized vitiligo.[2] The National Institutes of Health states that some believe that sunburns can cause or exacerbate the condition, but that this idea is not well-supported by good evidence.[14]

Immune

Variations in genes that are part of the immune system or part of melanocytes have both been associated with vitiligo.[2] It is also thought to be caused by the immune system attacking and destroying the melanocytes of the skin.[15] A genome wide association study found approximately 36 independent susceptibility loci for generalized vitiligo.[16]

Autoimmune associations

Vitiligo is sometimes associated with autoimmune and inflammatory diseases such as Hashimoto's thyroiditis, scleroderma, rheumatoid arthritis, type 1 diabetes mellitus, psoriasis, Addison's disease, pernicious anemia, alopecia areata, systemic lupus erythematosus, and celiac disease.[2][17]

Among the inflammatory products of NALP1 are caspase 1 and caspase 7, which activate the inflammatory cytokine interleukin-1β. Interleukin-1β and interleukin-18 are expressed at high levels in people with vitiligo.[18] In one of the mutations, the amino acid leucine in the NALP1 protein was replaced by histidine (Leu155 → His). The original protein and sequence is highly conserved in evolution, and is found in humans, chimpanzee, rhesus monkey, and the bush baby. Addison's disease (typically an autoimmune destruction of the adrenal glands) may also be seen in individuals with vitiligo.[19][20]

Diagnosis

UV photograph of a hand with vitiligo
UV photograph of a foot with vitiligo

An ultraviolet light can be used in the early phase of this disease for identification and to determine the effectiveness of treatment.[21] Using a Wood's light, skin will change colour (fluoresce) when it is affected by certain bacteria, fungi, and changes to pigmentation of the skin.[22]

Classification

Classification attempts to quantify vitiligo have been analyzed as being somewhat inconsistent,[23] while recent consensus have agreed to a system of segmental vitiligo (SV) and non-segmental vitiligo (NSV). NSV is the most common type of vitiligo.[2]

Non-segmental

In non-segmental vitiligo (NSV), there is usually some form of symmetry in the location of the patches of depigmentation. New patches also appear over time and can be generalized over large portions of the body or localized to a particular area. Extreme cases of vitiligo, to the extent that little pigmented skin remains, are referred to as vitiligo universalis. NSV can come about at any age (unlike segmental vitiligo, which is far more prevalent in teenage years).[11]

Classes of non-segmental vitiligo include the following:

  • Generalized vitiligo: the most common pattern, wide and randomly distributed areas of depigmentation[24]
  • Universal vitiligo: depigmentation encompasses most of the body[24]
  • Focal vitiligo: one or a few scattered macules in one area, most common in children[24]
  • Acrofacial vitiligo: fingers and periorificial areas[24]
  • Mucosal vitiligo: depigmentation of only the mucous membranes[24]

Segmental

Segmental vitiligo (SV) differs in appearance, cause, and frequency of associated illnesses. Its treatment is different from that of NSV. It tends to affect areas of skin that are associated with dorsal roots from the spinal cord and is most often unilateral.[2][25] It is much more stable/static in course and its association with autoimmune diseases appears to be weaker than that of generalized vitiligo.[25] SV does not improve with topical therapies or UV light, however surgical treatments such as cellular grafting can be effective.[11]

Differential diagnosis

Chemical leukoderma is a similar condition due to multiple exposures to chemicals.[1] Vitiligo however is a risk factor.[1]Triggers may include inflammatory skin conditions, burns, intralesional steroid injections and abrasions.[1]

Other conditions with similar symptoms include the following:

Treatment

There is no cure for vitiligo but several treatment options are available.[2] The best evidence is for applied steroids and the combination of ultraviolet light in combination with creams.[26] Due to the higher risks of skin cancer, the United Kingdom's National Health Service suggests phototherapy be used only if primary treatments are ineffective.[27] Lesions located on the hands, feet, and joints are the most difficult to repigment; those on the face are easiest to return to the natural skin color as the skin is thinner in nature.[2]

Immune mediators

Topical preparations of immune suppressing medications including glucocorticoids (such as 0.05% clobetasol or 0.10% betamethasone) and calcineurin inhibitors (such as tacrolimus or pimecrolimus) are considered to be first-line vitiligo treatments.[2]

Phototherapy

Phototherapy is considered a second-line treatment for vitiligo.[2] Exposing the skin to light from UVB lamps is the most common treatment for vitiligo. The treatments can be done at home with an UVB lamp or in a clinic. The exposure time is managed so that the skin does not suffer overexposure. Treatment can take a few weeks if the spots are on the neck and face and if they existed not more than 3 years. If the spots are on the hands and legs and have been there for more than 3 years, it can take a few months. Phototherapy sessions are done 2–3 times a week. Spots on a large area of the body may require full body treatment in a clinic or hospital. UVB broadband and narrowband lamps can be used,[28][29] but narrowband ultraviolet picked around 311 nm is the choice. It has been constitutively reported that a combination of UVB phototherapy with other topical treatments improves re-pigmentation. However, some people with vitiligo may not see any changes to skin or re-pigmentation occurring. A serious potential side effect involves the risk of developing skin cancer, the same risk as an overexposure to natural sunlight.

Ultraviolet light (UVA) treatments are normally carried out in a hospital clinic. Psoralen and ultraviolet A light (PUVA) treatment involves taking a drug that increases the skin's sensitivity to ultraviolet light, then exposing the skin to high doses of UVA light. Treatment is required twice a week for 6–12 months or longer. Because of the high doses of UVA and psoralen, PUVA may cause side effects such as sunburn-type reactions or skin freckling.[27]

Narrowband ultraviolet B (NBUVB) phototherapy lacks the side-effects caused by psoralens and is as effective as PUVA.[2] As with PUVA, treatment is carried out twice weekly in a clinic or every day at home, and there is no need to use psoralen.[27] Longer treatment is often recommended, and at least 6 months may be required for effects to phototherapy.[30] NBUVB phototherapy appears better than PUVA therapy with the most effective response on the face and neck.[30]

With respect to improved repigmentation: topical calcineurin inhibitors plus phototherapy are better than phototherapy alone,[31] hydrocortisone plus laser light is better than laser light alone, gingko biloba is better than placebo, and oral mini-pulse of prednisolone (OMP) plus NB-UVB is better than OMP alone.[9]

Skin camouflage

In mild cases, vitiligo patches can be hidden with makeup or other cosmetic camouflage solutions. If the affected person is pale-skinned, the patches can be made less visible by avoiding tanning of unaffected skin.[24]

De-pigmenting

In cases of extensive vitiligo the option to de-pigment the unaffected skin with topical drugs like monobenzone, mequinol, or hydroquinone may be considered to render the skin an even color. The removal of all the skin pigment with monobenzone is permanent and vigorous. Sun-safety must be adhered to for life to avoid severe sunburn and melanomas. Depigmentation takes about a year to complete.[27]

History

Descriptions of a disease believed to be vitiligo date back to a passage in the medical text Ebers Papyrus c. 1500 BCE in ancient Egypt. Mentions of whitening of the skin were also present circa 1400 BCE in sacred Indian texts such as Atharvaveda as well as Shinto prayers in East Asia c. 1200 BCE. The Hebrew word "Tzaraath" from the Old Testament book of Leviticus[32] dating to 1280 BCE[33] (or 1312 BCE[34]) described a group of skin diseases associated with white spots, and a subsequent translation to Greek led to continued conflation of those with vitiligo with leprosy and spiritual uncleanliness.[32]

Medical sources in the ancient world such as Hippocrates often did not differentiate between vitiligo and leprosy, often grouping these diseases together. In Arabic literature, the word "alabras" has been associated with vitiligo, with this word found in the Quran. The name "vitiligo" was first used by the Roman physician Aulus Cornelius Celsus in his classic medical text De Medicina.[32]

The etymology of the term "vitiligo" is believed to be derived from "vitium", meaning "defect" or "blemish".[32]

Society and culture

The change in appearance caused by vitiligo can affect a person's emotional and psychological well-being and may create difficulty in becoming or remaining employed, particularly if vitiligo develops on visible areas of the body, such as the face, hands, or arms. Participating in a vitiligo support group may improve social coping skills and emotional resilience.[35] Notable cases include that of American pop singer Michael Jackson[36] and Canadian fashion model Winnie Harlow.[37]

Research

Afamelanotide is in phase II and III clinical trials for vitiligo and other skin diseases.[38]

A medication for rheumatoid arthritis, tofacitinib, has been tested for the treatment of vitiligo.[39]

In October 1992, a scientific report was published of successfully transplanting melanocytes to vitiligo affected areas, effectively re-pigmenting the region.[40] The procedure involved taking a thin layer of pigmented skin from the person's gluteal region. Melanocytes were then separated out to a cellular suspension that was expanded in culture. The area to be treated was then denuded with a dermabrader and the melanocytes graft applied. Between 70 and 85 percent of people with vitiligo experienced nearly complete repigmentation of their skin. The longevity of the repigmentation differed from person to person.[41]

References

  1. 1 2 3 4 5 6 7 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 871-874. ISBN 978-0-323-54753-6. Archived from the original on 2 July 2023. Retrieved 4 May 2023.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 Ezzedine, K; Eleftheriadou, V; Whitton, M; van Geel, N (4 July 2015). "Vitiligo". Lancet. 386 (9988): 74–84. doi:10.1016/s0140-6736(14)60763-7. PMID 25596811.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 "Questions and Answers about Vitiligo". NIAMS. June 2014. Archived from the original on 21 August 2016. Retrieved 11 August 2016.
  4. 1 2 3 Whitton, M; Pinart, M; Batchelor, JM; et al. (May 2016). "Evidence-based management of vitiligo: summary of a Cochrane systematic review". The British Journal of Dermatology. 174 (5): 962–69. doi:10.1111/bjd.14356. PMID 26686510.
  5. ↑ Chopra, Parul; Niyogi, Rageshree; Katyal, Gauri (2009). Skin and Hair Care: Your Questions Answered. Byword Books Private Limited. p. 2. ISBN 978-8181930378. Archived from the original on 23 March 2017.
  6. ↑ Krüger C; Schallreuter KU (October 2012). "A review of the worldwide prevalence of vitiligo in children/adolescents and adults". Int J Dermatol. 51 (10): 1206–12. arXiv:0706.4406. doi:10.1111/j.1365-4632.2011.05377.x. PMID 22458952.
  7. 1 2 3 4 National Institute of Arthritis and Musculoskeletal and Skin Diseases (March 2007). "What Is Vitiligo? Fast Facts: An Easy-to-Read Series of Publications for the Public Additional". Archived from the original on 15 July 2010. Retrieved 18 July 2010.
  8. 1 2 3 Halder RM (2007). "72. Vitiligo". In Wolff K, Freedberg IM, Fitzpatrick TB (eds.). Fitzpatrick's dermatology in general medicine (7th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-146690-5. OCLC 154751587.
  9. 1 2 Whitton, ME; Pinart, M; Batchelor, J; Leonardi-Bee, J; González, U; Jiyad, Z; Eleftheriadou, V; Ezzedine, K (24 February 2015). "Interventions for vitiligo". The Cochrane Database of Systematic Reviews (2): CD003263. doi:10.1002/14651858.CD003263.pub5. PMID 25710794.
  10. ↑ Halder, RM; Chappell, JL (2009). "Vitiligo update". Seminars in Cutaneous Medicine and Surgery. 28 (2): 86–92. doi:10.1016/j.sder.2009.04.008. PMID 19608058.
  11. 1 2 3 Huggins RH, Schwartz RA, Janniger CK (2005). "Vitiligo" (PDF). Acta Dermatovenerologica Alpina, Pannonica et Adriatica. 14 (4): 137–42, 144–45. PMID 16435042. Archived (PDF) from the original on 10 December 2006.
  12. ↑ Picardi A, Pasquini P, Cattaruzza MS, Gaetano P, Melchi CF, Baliva G, Camaioni D, Tiago A, Abeni D, Biondi M (2003). "Stressful life events, social support, attachment security and alexithymia in vitiligo. A case-control study". Psychotherapy and Psychosomatics. 72 (3): 150–58. doi:10.1159/000069731. PMID 12707482. Archived from the original on 27 August 2021. Retrieved 20 July 2020. {{cite journal}}: Unknown parameter |displayauthors= ignored (help)
  13. ↑ Ongenae, Katia; Van Geel, Nanny; Naeyaert, Jean-Marie (April 2003). "Evidence for an Autoimmune Pathogenesis of Vitiligo". Pigment Cell Research. 16 (2): 90–100. doi:10.1034/j.1600-0749.2003.00023.x. PMID 12622785.
  14. ↑ "Questions and Answers about Vitiligo". National Institute of Arthritis and Musculoskeletal and Skin Diseases. 30 October 2016. Archived from the original on 8 August 2007. Retrieved 22 July 2018.
  15. ↑ Staff, Mayo Clinic (15 May 2014). "Vitiligo Causes". Mayoclinic. Archived from the original on 30 April 2015. Retrieved 22 April 2015.
  16. ↑ Spritz, Richard A. (May 2013). "Modern vitiligo genetics sheds new light on an ancient disease". The Journal of Dermatology. 40 (5): 310–18. doi:10.1111/1346-8138.12147. PMC 3783942. PMID 23668538.
  17. ↑ Van Driessche F, Silverberg N (2015). "Current Management of Pediatric Vitiligo". Paediatr Drugs (Review). 17 (4): 303–13. doi:10.1007/s40272-015-0135-3. PMID 26022363. Archived from the original on 27 August 2021. Retrieved 20 July 2020.
  18. ↑ Lamkanfi M, Vande Walle L, Kanneganti TD (2011). "Deregulated inflammasome signaling in disease". Immunol Rev (Review). 243 (1): 163–73. doi:10.1111/j.1600-065X.2011.01042.x. PMC 3170132. PMID 21884175.
  19. ↑ Gregersen PK (2007). "Modern genetics, ancient defenses, and potential therapies". The New England Journal of Medicine. 356 (12): 1263–66. doi:10.1056/NEJMe078017. PMID 17377166.
  20. ↑ Jin Y, Mailloux CM, Gowan K, et al. (2007). "NALP1 in vitiligo-associated multiple autoimmune disease" (PDF). The New England Journal of Medicine. 356 (12): 1216–25. doi:10.1056/NEJMoa061592. PMID 17377159. Archived (PDF) from the original on 6 March 2020. Retrieved 20 July 2020.
  21. ↑ Wang, Yen-Jen; Chang, Chang-Cheng; Cheng, Kun-Lin (December 2017). "Wood's lamp for vitiligo disease stability and early recognition of initiative pigmentation after epidermal grafting". International Wound Journal. 14 (6): 1391–94. doi:10.1111/iwj.12800. PMID 28799192.
  22. ↑ Al Aboud, Daifallah M.; Gossman, William (2019). "Woods Light (Woods Lamp)". StatPearls. StatPearls Publishing. PMID 30725878.
  23. ↑ Picardo, Mauro; Taïeb, Alain, eds. (2009). "Introduction". Vitiligo. Berlin: Springer. ISBN 978-3-540-69360-4.
  24. 1 2 3 4 5 6 7 8 9 10 Halder, R. M.; et al. (2007). "Vitiligo". In Wolff, K.; et al. (eds.). Fitzpatrick's Dermatology in General Medicine (7th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-146690-5.
  25. 1 2 van Geel N, Mollet I, Brochez L, Dutré M, De Schepper S, Verhaeghe E, Lambert J, Speeckaert R (February 2012). "New insights in segmental vitiligo: case report and review of theories". British Journal of Dermatology. 166 (2): 240–46. doi:10.1111/j.1365-2133.2011.10650.x. PMID 21936857. {{cite journal}}: Unknown parameter |displayauthors= ignored (help)
  26. ↑ Whitton, ME; Ashcroft, DM; González, U (October 2008). "Therapeutic interventions for vitiligo". Journal of the American Academy of Dermatology. 59 (4): 713–17. doi:10.1016/j.jaad.2008.06.023. PMID 18793940.
  27. 1 2 3 4 Anon. "Vitiligo -Treatment". Patient UK. NHS. Archived from the original on 6 June 2013. Retrieved 3 June 2013.
  28. ↑ Scherschun, L; Kim, JJ; Lim, HW (2001). "Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo". Journal of the American Academy of Dermatology. 44 (6): 999–1003. doi:10.1067/mjd.2001.114752. PMID 11369913. Archived from the original on 27 August 2021. Retrieved 20 July 2020.
  29. ↑ Don, Philip; Iuga, Aurel; Dacko, Anne; Hardick, Kathleen (2006). "Treatment of vitiligo with broadband ultraviolet B and vitamins". International Journal of Dermatology. 45 (1): 63–65. doi:10.1111/j.1365-4632.2005.02447.x. PMID 16426381.
  30. 1 2 Bae, Jung Min; Jung, Han Mi; Hong, Bo Young; Lee, Joo Hee; Choi, Won Joon; Lee, Ji Hae; Kim, Gyong Moon (1 July 2017). "Phototherapy for Vitiligo: A Systematic Review and Meta-analysis". JAMA Dermatology. 153 (7): 666–74. doi:10.1001/jamadermatol.2017.0002. ISSN 2168-6068. PMC 5817459. PMID 28355423.
  31. ↑ Bae, Jung Min; Hong, Bo Young; Lee, Joo Hee; Lee, Ji Hae; Kim, Gyong Moon (May 2016). "The efficacy of 308-nm excimer laser/light (EL) and topical agent combination therapy versus EL monotherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials (RCTs)". Journal of the American Academy of Dermatology. 74 (5): 907–15. doi:10.1016/j.jaad.2015.11.044. PMID 26785803.
  32. 1 2 3 4 Gauthier, Yvon; Benzekri, Laila (2009). "Historical Aspects". In Picardo, Mauro; Taïeb, Alain (eds.). Vitiligo (Online-Ausg. ed.). Berlin: Springer. ISBN 978-3-540-69360-4.
  33. ↑ Kurzweil, Arthur (2008). The Torah For Dummies (PDF). For Dummies. p. 11. ISBN 978-0-470-28306-6. Archived (PDF) from the original on 22 June 2020. Retrieved 19 August 2010.
  34. ↑ History Crash Course #36: Timeline: From Abraham to Destruction of the Temple Archived 20 July 2014 at the Wayback Machine, by Rabbi Ken Spiro, Aish.com. Retrieved 2010-08-19.
  35. ↑ Chaturvedi, SK; Singh, G; Gupta, N (October 2005). "Stigma experience in skin disorders: an Indian perspective". Dermatologic Clinics. 23 (4): 635–42. doi:10.1016/j.det.2005.05.007. PMID 16112439.
  36. ↑ Vogel, Joseph (17 March 2018). "Black and White: how Dangerous kicked off Michael Jackson's race paradox". The Guardian. Archived from the original on 17 March 2018. Retrieved 14 September 2019.
  37. ↑ "Winnie Harlow: Canadian Model With Rare Skin Condition Lands 2 Major Campaigns". Complex. Archived from the original on 23 October 2020. Retrieved 17 February 2020.
  38. ↑ Fabrikant J; et al. (July 2013). "A review and update on melanocyte stimulating hormone therapy: afamelanotide". J Drugs Dermatol. 12 (7): 775–79. PMID 23884489.
  39. ↑ "For vitiligo patient, arthritis drug restores skin color". 24 June 2015. Archived from the original on 22 July 2015.
  40. ↑ Olsson MJ, Juhlin L (1992). "Melanocyte transplantation in vitiligo". Lancet. 340 (8825): 981. doi:10.1016/0140-6736(92)92875-G. PMID 1357390. Archived from the original on 27 August 2021. Retrieved 20 July 2020.
  41. ↑ Olsson MJ, Juhlin L (2002). "Long-term follow-up of leucoderma patients treated with transplants of autologous cultured melanocytes, ultrathin epidermal sheets and basal cell layer suspension". The British Journal of Dermatology. 147 (5): 893–904. doi:10.1046/j.1365-2133.2002.04837.x. PMID 12410698.
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