AdCLD-CoV19

AdCLD-CoV19 is a COVID-19 vaccine candidate developed by Cellid Co,[1][2] a company from South Korea.[3]

AdCLD-CoV19
Vaccine description
TargetSARS-CoV-2
Vaccine typeViral vector
Clinical data
Routes of
administration
Intramuscular

A phase 1/2 trial of a single injection of AdCLD-CoV19 began in December 2020 in South Korea.[4] In September 2021, a phase 1 trial began for a single injection of another version, named AdCLD-CoV19-1.[5] Preclinical studies of a single dose in mice and non-human primates for this vaccine candidate were published in April 2022.[6] In August 2022, a phase 2 trial of 1 or 2 doses of AdCLD-CoV19-1 was registered.[7]

References

  1. Chan-Hyuk K (10 December 2020). "LG Chem pushes for Covid-19 vaccine CMO deal". Korea Biomedical Review. Retrieved 22 August 2021.
  2. Chan-hyuk K (11 August 2021). "Covid-19 vaccine trials stalled by rare chance to get licensed vaccines". Korea Biomedical Review. Retrieved 22 August 2021.
  3. "Cellid Co Ltd, Company Profile and News". Bloomberg Markets.
  4. Clinical trial number NCT04666012 for "Safety and Immunogenicity Study of AdCLD-CoV19: A COVID-19 Preventive Vaccine in Healthy Volunteers" at ClinicalTrials.gov
  5. Cellid Co (21 January 2022). "A Dose Escalation, Multicenter, Open, Phase I Study to Assess the Safety and Immunogenicity of AdCLD-CoV19-1, a COVID-19 Preventive Vaccine in Healthy Volunteers". clinicaltrials.gov. National Institutes of Health. Retrieved 27 September 2022.
  6. Shin, Seung-Phil; Shin, Kwang-Soo; Lee, Jeong-Mi; Jung, In-Kyung; Koo, Jimo; Lee, Seung-Woo; Park, Seowoo; Shin, Jieun; Park, Myunghwan; Park, Bongju; Oh, Hanseul; Koo, Bon-Sang; Hong, Jungjoo; Ryu, Choong-Min; Kim, Jae-Ouk; Oh, Taegwon; Kang, Chang-Yuil (May 2022). "The Chimeric Adenovirus (Ad5/35) Expressing Engineered Spike Protein Confers Immunity against SARS-CoV-2 in Mice and Non-Human Primates". Vaccines. 10 (5): 712. doi:10.3390/vaccines10050712. PMC 9147121. PMID 35632468.
  7. Cellid Co (27 August 2022). "A Phase IIb, Multicenter, Observer-Blinded, Randomized, Placebo-Controlled Trial to Evaluate the Immunogenicity and Safety of the AdCLD-CoV19-1 in Healthy Adults Aged 19 Years Old and Above". clinicaltrials.gov. National Institutes of Health. Retrieved 27 September 2022.


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