Clonitazene

Clonitazene is an opioid analgesic of approximately three times the potency of morphine.[1] It is related to etonitazene, an opioid of significantly higher potency. Clonitazene is not currently marketed. It is a controlled substance; in the United States it is a Schedule I Narcotic controlled substance with a DEA ACSCN of 9612 and an established manufacturing quota of 25 grams for 2022.

Clonitazene
Clinical data
Other namesClonitazene
ATC code
  • none
Legal status
Legal status
  • CA: Schedule I
  • DE: Anlage I (Authorized scientific use only)
  • UK: Class A
  • US: Schedule I
Identifiers
IUPAC name
  • 2-[2-[(4-Chlorophenyl)methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H23ClN4O2
Molar mass386.88 g·mol−1
3D model (JSmol)
SMILES
  • [O-][N+](=O)c3ccc1c(nc(n1CCN(CC)CC)Cc2ccc(Cl)cc2)c3
InChI
  • InChI=1S/C20H23ClN4O2/c1-3-23(4-2)11-12-24-19-10-9-17(25(26)27)14-18(19)22-20(24)13-15-5-7-16(21)8-6-15/h5-10,14H,3-4,11-13H2,1-2H3 Y
  • Key:GPZLDQAEBHTMPG-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

References
  1. Hunger A, Kebrle J, Rossi A, Hoffmann K (October 1957). "[Synthesis of analgesically active benzimidazole derivatives with basic substitutions]" [Synthesis of analgesically active benzimidazole derivatives with basic substitutions]. Experientia. 13 (10): 400–1. doi:10.1007/BF02161116. PMID 13473817. S2CID 32179439.
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