Codoxime

Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6-ketone group has been replaced by carboxymethyloxime. It has primarily antitussive effects[1] and was found to have moderate potential to cause dependence in animal studies.[2]

Codoxime
Clinical data
Other namesCodoxime
ATC code
  • none
Legal status
Legal status
  • CA: Schedule I
  • DE: Anlage I (Authorized scientific use only)
  • UN: Narcotic Schedule I
Identifiers
IUPAC name
  • (((4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-ylidene)amino)oxy)acetic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.027.660
Chemical and physical data
FormulaC20H24N2O5
Molar mass372.421 g·mol−1
3D model (JSmol)
SMILES
  • O=C(O)CO\N=C4\[C@@H]5Oc1c2c(ccc1OC)C[C@H]3N(CC[C@]25[C@H]3CC4)C

References
  1. US granted 3153042, Jack Fishman, "Morphinone and Codeinone Derivatives", issued 13 October 1964, assigned to Mozes Juda Lowenstein
  2. Jasinski DR, Martin WR (1967). "Assessment of the dependence-producing properties of dihydrocodeinone and codoxime". Clinical Pharmacology and Therapeutics. 8 (2): 266–70. doi:10.1002/cpt196782266. PMID 6021586. S2CID 36504901.



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