LY-88329

LY-88329 is an opioid receptor ligand related to medicines such as pethidine. It has high affinity to the μ-opioid receptor, but unlike structurally related drugs such as 3-methylfentanyl and OPPPP, LY-88329 is a potent opioid antagonist. In animal studies it blocks the effects of morphine and has anorectic action.[1][2]

LY-88329
Identifiers
IUPAC name
  • 3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-1-phenylpropan-1-one
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC22H27NO2
Molar mass337.463 g·mol−1
3D model (JSmol)
SMILES
  • C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CCC(=O)C3=CC=CC=C3
InChI
  • InChI=1S/C22H27NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h3-10,15,17,24H,11-14,16H2,1-2H3/t17-,22+/m0/s1
  • Key:IQGJBVSSFDCTAJ-HTAPYJJXSA-N

See also

References
  1. Leander JD (July 1981). "Behavioral effects of phenylpiperidine narcotic antagonists". Pharmacology, Biochemistry, and Behavior. 15 (1): 65–70. doi:10.1016/0091-3057(81)90340-3. PMID 7291232. S2CID 24797157.
  2. Shaw WN, Mitch CH, Leander JD, Zimmerman DM (April 1990). "Effect of phenylpiperidine opioid antagonists on food consumption and weight gain of the obese Zucker rat". The Journal of Pharmacology and Experimental Therapeutics. 253 (1): 85–9. PMID 2329525.



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