Oxiconazole

Oxiconazole
Names
Trade namesOxistat, Oxizole, others
IUPAC name
  • (E)-[1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethylidene][(2,4-dichlorophenyl)methoxy]amine
Clinical data
Drug classAntifungal
Main usesAthlete's foot, jock itch, ringworm, tinea versicolor, yeast infections[1]
Side effectsIrritation, burning, itching[1]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
External links
AHFS/Drugs.comMonograph
MedlinePlusa689004
Chemical and physical data
FormulaC18H13Cl4N3O
Molar mass429.12 g·mol−1
3D model (JSmol)
SMILES
  • Clc3ccc(/C(=N\OCc1ccc(Cl)cc1Cl)Cn2ccnc2)c(Cl)c3
InChI
  • InChI=1S/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18- checkY
  • Key:QRJJEGAJXVEBNE-MOHJPFBDSA-N checkY

Oxiconazole, sold under the brand name Oxistat among others, is an antifungal medication used to treat athlete's foot, jock itch, ringworm, tinea versicolor, and yeast infections.[1] It is typically applied to the skin as a cream or lotion.[1]

Common side effects include irritation, burning, and itching.[1] Other side effects may include contact dermatitis.[1] Use appears to be safe in pregnancy, though has not been well studied.[2] It is in the azole family of medications.[1] It is believed to work by increasing the permeability of the cellular membrane.[1]

Oxiconazole was patented in 1975 and approved for medical use in 1983.[3] It is available as a generic medication.[4] In the United States a tube of 30 grams costs about 110 USD.[4]

See also

References

  1. 1 2 3 4 5 6 7 8 "Oxiconazole Monograph for Professionals". Drugs.com. Archived from the original on 18 January 2021. Retrieved 10 November 2021.
  2. ↑ "Oxiconazole topical (Oxistat) Use During Pregnancy". Drugs.com. Archived from the original on 25 January 2021. Retrieved 10 November 2021.
  3. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 503. ISBN 9783527607495. Archived from the original on 2017-09-10. Retrieved 2020-09-20.
  4. 1 2 "Oxiconazole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 May 2016. Retrieved 10 November 2021.
Identifiers:
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