Fenticonazole

Fenticonazole
Clinical data
Trade names	Lomexin, Gynoxin
AHFS/Drugs.com	International Drug Names
Routes of; administration	Topical (ovule, spray, cream)
ATC code	D01AC12 (WHO) G01AF12 (WHO);
Legal status
Legal status	UK: POM (Prescription only) ; US: Not approved ; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)phenyl]methoxy}ethyl]-1H-imidazole;
CAS Number	72479-26-6 ;
PubChem CID	51755;
ChemSpider	46840 ;
UNII	QG05NRB077;
KEGG	D02582 ;
ChEBI	CHEBI:82863 ;
CompTox Dashboard (EPA)	DTXSID7057812 ;
Chemical and physical data
Formula	C24H20Cl2N2OS
Molar mass	455.40 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1ccc(cc1)Sc2ccc(cc2)COC(Cn3ccnc3)c4ccc(cc4Cl)Cl;
	InChI InChI=1S/C24H20Cl2N2OS/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20/h1-14,17,24H,15-16H2 ; Key:ZCJYUTQZBAIHBS-UHFFFAOYSA-N ;
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Fenticonazole is an imidazole antifungal drug, used locally as the nitrate in the treatment of vulvovaginal candidiasis. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans.

Uses and administration

A 200 mg pessary is inserted into the vagina at bedtime for 3 nights or a 600 mg pessary is inserted once only at bedtime. Fenticonazole nitrate is also applied topically as a 2% cream or solution for the treatment of fungal skin infections.

Adverse effects

Burning and itching have been reported after the application of fenticonazole nitrate.

Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local administration.

References

The Merck Index, 12th Edition. 4047

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