Flutrimazole

Flutrimazole
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • (RS)-1-[(2-Fluorophenyl)(4-fluorophenyl)benzyl]-1H-imidazole
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.170.770
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Chemical and physical data
FormulaC22H16F2N2
Molar mass346.381 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
SMILES
  • Fc1ccc(cc1)C(c2c(F)cccc2)(c3ccccc3)n4ccnc4
InChI
  • InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H checkY
  • Key:QHMWCHQXCUNUAK-UHFFFAOYSA-N checkY
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Flutrimazole is a wide-spectrum antifungal drug. It is used for the topical treatment of superficial mycoses of the skin. Flutrimazole is an imidazole derivative. Its antifungal activity has been demonstrated in in vivo and in vitro studies to be comparable to that of clotrimazole and higher than bifonazole.[1]

Mechanism of action

It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol 14 α-demethylase.

See also

References

The Merck Index, 12th Edition. 4247

  1. ↑ Alomar A, Videla S, Delgadillo J, Gich I, Izquierdo I, Forn J (1995). "Flutrimazole 1% dermal cream in the treatment of dermatomycoses: a multicentre, double-blind, randomized, comparative clinical trial with bifonazole 1% cream. Efficacy of flutrimazole 1% dermal cream in dermatomycoses. Catalan Flutrimazole Study Group". Dermatology. 190 (4): 295–300. doi:10.1159/000246720. PMID 7655109.
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