Sotagliflozin

Sotagliflozin
Names
Pronunciation/ˌsoʊtəɡlɪˈfloʊzɪn/
SOH-tə-gli-FLOH-zin
Trade namesInpefa, Zynquista
Clinical data
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Routes of
use		By mouth
Legal
License data
Legal status
Chemical and physical data
FormulaC21H25ClO5S
Molar mass424.94 g·mol−1
3D model (JSmol)
SMILES
  • CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)SC)O)O)O)Cl
InChI
  • InChI=1S/C21H25ClO5S/c1-3-26-15-7-4-12(5-8-15)10-14-11-13(6-9-16(14)22)20-18(24)17(23)19(25)21(27-20)28-2/h4-9,11,17-21,23-25H,3,10H2,1-2H3/t17-,18-,19+,20+,21-/m1/s1
  • Key:QKDRXGFQVGOQKS-CRSSMBPESA-N

Sotagliflozin, sold under the brand name Inpefa among others, is a medication used for heart failure.[1]

Common side effect is genital infection in women.[2] Other common side effects include diabetic ketoacidosis, diarrhea, and genital infection in men.[2]

Sotagliflozin was approved for medical use in Europe in 2019, for the treatment for type 1 diabetes,[2] and in the United States in 2023, to reduce the risk of death due to heart failure.[1][3] Its approval was withdrawn in Europe in 2022.[2]

Medical uses

In the United States, sotagliflozin is indicated to reduce the risk of cardiovascular death.[1] Sotaglifozin is a sodium-glucose co-transporter 1 and 2 inhibitor that reduces both postprandial glucose and insulin levels by delaying intestinal glucose absorption, decreases gastric inhibitory polypeptide, and elevations in glucagon-like peptide and peptide yy levels are consistent with local inhibition of intestinal SGLT1.[4] Combination of insulin with sotaglifozin 200 and 400 mg led to a significant lowering of systolic and diastolic blood pressure and multiple indirect markers of arterial stiffness, including pulse pressure, without changes in pulse rates.[5] Also, it decreased the incidence of myocardial infarction and stroke, pointing to a potential side effect of SGLT1 inhibition.[6]

Society and culture

The US Food and Drug Administration (FDA) refused its approval for use in combination with insulin for the treatment of type 1 diabetes. It is developed by Lexicon Pharmaceuticals.[7][8][9]

References

  1. 1 2 3 4 "Inpefa- sotagliflozin tablet". DailyMed. 5 June 2023. Archived from the original on 26 June 2023. Retrieved 25 June 2023.
  2. 1 2 3 4 5 "Zynquista EPAR". European Medicines Agency (EMA). 27 February 2019. Archived from the original on 3 November 2020. Retrieved 28 October 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  3. ↑ "Lexicon Announces FDA Approval of Inpefa (sotagliflozin) for Treatment of Heart Failure" (Press release). Lexicon Pharmaceuticals. 26 May 2023. Archived from the original on 20 October 2023. Retrieved 28 May 2023 – via GlobeNewswire.
  4. ↑ Powell, D. R.; Zambrowicz, B.; Morrow, L.; Beysen, C.; Hompesch, M.; Turner, S.; Hellerstein, M.; Banks, P.; Strumph, P.; Lapuerta, P. Sotagliflozin Decreases Postprandial Glucose and Insulin Concentrations by Delaying Intestinal Glucose Absorption. The Journal of Clinical Endocrinology & Metabolism 2020, 105 (4), e1235–e1249. https://doi.org/10.1210/clinem/dgz258 Archived 2023-08-18 at the Wayback Machine.
  5. ↑ Rodbard, H. W.; Giaccari, A.; Cariou, B.; Garg, S.; Davies, M. J.; Seth, K.; Sawhney, S. Effect of Sotagliflozin as an Adjunct to Insulin Therapy on Blood Pressure and Arterial Stiffness in Adults with Type 1 Diabetes: A Post Hoc Pooled Analysis of InTandem1 and InTandem2. Diab Vasc Dis Res 2021, 18 (1), 1479164121995928. https://doi.org/10.1177/1479164121995928 Archived 2023-08-18 at the Wayback Machine.
  6. ↑ Sayour, A. A.; Ruppert, M.; Oláh, A.; Benke, K.; Barta, B. A.; Zsáry, E.; Merkely, B.; Radovits, T. Effects of SGLT2 Inhibitors beyond Glycemic Control-Focus on Myocardial SGLT1. Int J Mol Sci 2021, 22 (18), 9852. https://doi.org/10.3390/ijms22189852 Archived 2023-08-18 at the Wayback Machine
  7. ↑ "Sotagliflozin as an Adjunct to Insulin for Type 1 Diabetes" (PDF). U.S. Food and Drug Administration (FDA). Archived (PDF) from the original on 26 April 2019. Retrieved 1 April 2019.
  8. ↑ "Sanofi: FDA advisory committee votes on Zynquista (sotagliflozin) as treatment for adults with type 1 diabetes" (Press release). Sanofi. 17 January 2019. Archived from the original on 1 August 2019. Retrieved 1 April 2019 – via GlobeNewswire.
  9. ↑ "Sanofi: FDA advisory committee votes on Zynquista (sotagliflozin) as treatment for adults with type 1 diabetes". Sanofi (Press release). 18 January 2019. Archived from the original on 29 November 2020. Retrieved 28 October 2020.

Further reading

Identifiers:
  • Clinical trial number NCT03521934 for "Effect of Sotagliflozin on Cardiovascular Events in Participants With Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF Trial)" at ClinicalTrials.gov
  • Clinical trial number NCT03315143 for "Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk (SCORED)" at ClinicalTrials.gov


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