PYCARD

PYCARD
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1UCP, 2KN6, 3J63, 5H8O
المعرفات
الأسماء المستعارة	PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 606838 MGI: MGI:1931465 HomoloGene: 8307 GeneCards: 29108
علم الوجود الجيني
الوظيفة الجزيئية	• protein homodimerization activity; • interleukin-6 receptor binding; • BMP receptor binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • identical protein binding; • enzyme binding; • cysteine-type endopeptidase activity involved in apoptotic process; • Pyrin domain binding; • cysteine-type endopeptidase activator activity involved in apoptotic process; • myosin I binding; • tropomyosin binding; • protease binding; • transmembrane transporter binding; • protein dimerization activity; • cysteine-type endopeptidase activity;
المكونات الخلوية	• سيتوبلازم; • NLRP3 inflammasome complex; • NLRP1 inflammasome complex; • AIM2 inflammasome complex; • نوية; • شبكة إندوبلازمية; • ميتوكندريون; • IkappaB kinase complex; • نواة; • secretory granule lumen; • azurophil granule lumen; • منطقة خارج الخلية; • عصارة خلوية; • ‏GO:0009327 protein-containing complex; • جسم الخلية العصبية; • Golgi membrane; • جهاز غولجي; • غشاء;
العمليات الحيوية	• positive regulation of cysteine-type endopeptidase activity; • regulation of apoptotic process; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • regulation of intrinsic apoptotic signaling pathway; • intrinsic apoptotic signaling pathway by p53 class mediator; • positive regulation of adaptive immune response; • ‏GO:0051636 defense response to Gram-negative bacterium; • immune system process; • cellular response to tumor necrosis factor; • regulation of tumor necrosis factor-mediated signaling pathway; • positive regulation of DNA-binding transcription factor activity; • tumor necrosis factor-mediated signaling pathway; • positive regulation of JNK cascade; • negative regulation of interferon-beta production; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • myeloid dendritic cell activation; • positive regulation of T cell activation; • defense response to virus; • cellular response to interleukin-1; • positive regulation of apoptotic process; • positive regulation of tumor necrosis factor production; • positive regulation of release of cytochrome c from mitochondria; • negative regulation of protein serine/threonine kinase activity; • positive regulation of extrinsic apoptotic signaling pathway; • inflammatory response; • cellular response to lipopolysaccharide; • negative regulation of NF-kappaB transcription factor activity; • ‏GO:0072468 توصيل الإشارة; • ‏GO:0097285 استماتة; • مناعة فطرية; • neutrophil degranulation; • positive regulation of NF-kappaB transcription factor activity; • activation of innate immune response; • myeloid dendritic cell activation involved in immune response; • positive regulation of antigen processing and presentation of peptide antigen via MHC class II; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of actin filament polymerization; • regulation of protein stability; • positive regulation of interferon-gamma production; • positive regulation of interleukin-6 production; • positive regulation of activated T cell proliferation; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • macropinocytosis; • positive regulation of phagocytosis; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of T cell migration; • positive regulation of defense response to virus by host; • intrinsic apoptotic signaling pathway in response to DNA damage; • response to bacterium; • regulation of autophagy; • interleukin-1 beta production; • ‏GO:0043087، ‏GO:0032313، ‏GO:0032319، ‏GO:0032314، ‏GO:0043088 regulation of GTPase activity; • regulation of cysteine-type endopeptidase activity involved in apoptotic process; • regulation of inflammatory response; • protein homooligomerization; • activation of cysteine-type endopeptidase activity; • negative regulation of cytokine production involved in inflammatory response; • تحلل بروتيني; • positive regulation of interleukin-1 beta production;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9ULZ3
	Q9EPB4
	‏NM_013258، ‏NM_145182 NM_145183، ‏NM_013258، ‏NM_145182
	NM_023258
	‏NP_660183 NP_037390، ‏NP_660183
	NP_075747
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

PYCARD‏ (PYD and CARD domain containing) هوَ بروتين يُشَفر بواسطة جين PYCARD في الإنسان.[1][2][3]

المراجع

Alba, Eva de (20 نوفمبر 2009)، "Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)"، Journal of Biological Chemistry (باللغة الإنجليزية)، 284 (47): 32932–32941، doi:10.1074/jbc.M109.024273، ISSN 0021-9258، PMC 2781708، PMID 19759015، مؤرشف من الأصل في 03 يونيو 2018.
"Entrez Gene: PYCARD PYD and CARD domain containing"، مؤرشف من الأصل في 05 ديسمبر 2010، اطلع عليه بتاريخ 18 سبتمبر 2010.
Dunn, JH؛ Fujita, M (2015)، "PYCARD (PYD and CARD domain containing)"، Atlas of Genetics and Cytogenetics in Oncology and Haematology (باللغة الإنجليزية) (4)، doi:10.4267/2042/56440، ISSN 1768-3262، مؤرشف من الأصل في 07 ديسمبر 2019.

قراءة متعمقة

"ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells"، J. Biol. Chem.، 274 (48): 33835–8، 1999، doi:10.1074/jbc.274.48.33835، PMID 10567338.
"Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2"، Mol. Endocrinol.، 14 (6): 915–25، 2000، doi:10.1210/mend.14.6.0471، PMID 10847592.
"TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers"، Cancer Res.، 60 (22): 6236–42، 2000، PMID 11103776.
"Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1"، Cancer Res.، 60 (22): 6243–7، 2000، PMID 11103777.
"The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation"، Curr. Biol.، 11 (4): R118-20، 2001، doi:10.1016/S0960-9822(01)00056-2، PMID 11250163.
"Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis"، Biochem. Biophys. Res. Commun.، 284 (1): 77–82، 2001، doi:10.1006/bbrc.2001.4928، PMID 11374873.
"Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis"، J. Biol. Chem.، 276 (42): 39320–9، 2001، doi:10.1074/jbc.M104730200، PMID 11498534.
"Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture"، J. Biol. Chem.، 277 (7): 4951–8، 2002، doi:10.1074/jbc.M109809200، PMID 11733524.
"PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B"، J. Biol. Chem.، 277 (13): 11570–5، 2002، doi:10.1074/jbc.M112208200، PMID 11786556.
"The PYRIN-CARD protein ASC is an activating adaptor for caspase-1"، J. Biol. Chem.، 277 (24): 21119–22، 2002، doi:10.1074/jbc.C200179200، PMID 11967258.
"PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing"، J. Biol. Chem.، 277 (33): 29874–80، 2002، doi:10.1074/jbc.M203915200، PMID 12019269.
"ASC, which is composed of a PYD and a CARD, is up-regulated by inflammation and apoptosis in human neutrophils"، Biochem. Biophys. Res. Commun.، 293 (5): 1314–8، 2002، doi:10.1016/S0006-291X(02)00384-4، PMID 12054656.
"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta"، Mol. Cell، 10 (2): 417–26، 2002، doi:10.1016/S1097-2765(02)00599-3، PMID 12191486.
"The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways"، J. Exp. Med.، 196 (12): 1605–15، 2002، doi:10.1084/jem.20021552، PMC 2196065، PMID 12486103.
"A proapoptotic caspase recruitment domain protein gene, TMS1, is hypermethylated in human breast and gastric cancers"، Anticancer Res.، 22 (6C): 4163–8، 2003، PMID 12553049.
"Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product"، Biochem. Biophys. Res. Commun.، 302 (3): 575–80، 2003، doi:10.1016/S0006-291X(03)00221-3، PMID 12615073.
"ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis"، Biochem. Biophys. Res. Commun.، 303 (1): 69–73، 2003، doi:10.1016/S0006-291X(03)00309-7، PMID 12646168.
"The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation"، Biochem. J.، 373 (Pt 1): 101–13، 2003، doi:10.1042/BJ20030304، PMC 1223462، PMID 12656673.
"Effects of methylation on expression of TMS1/ASC in human breast cancer cells"، Oncogene، 22 (22): 3475–88، 2003، doi:10.1038/sj.onc.1206430، PMID 12776200.

بوابة الكيمياء الحيوية
بوابة طب
بوابة علم الأحياء الخلوي والجزيئي

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[1] Alba, Eva de (20 نوفمبر 2009)، "Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)"، Journal of Biological Chemistry (باللغة الإنجليزية)، 284 (47): 32932–32941، doi:10.1074/jbc.M109.024273، ISSN 0021-9258، PMC 2781708، PMID 19759015، مؤرشف من الأصل في 03 يونيو 2018.

[entrez-2] "Entrez Gene: PYCARD PYD and CARD domain containing"، مؤرشف من الأصل في 05 ديسمبر 2010، اطلع عليه بتاريخ 18 سبتمبر 2010.

[:0-3] Dunn, JH؛ Fujita, M (2015)، "PYCARD (PYD and CARD domain containing)"، Atlas of Genetics and Cytogenetics in Oncology and Haematology (باللغة الإنجليزية) (4)، doi:10.4267/2042/56440، ISSN 1768-3262، مؤرشف من الأصل في 07 ديسمبر 2019.

التصنيفات الطبية	OMIM ID: 606838
المعرفات الخارجية	Ensembl Transcript ID: ENST00000565022, ENST00000247470, ENST00000350605, ENST00000561508