Estradiol/dydrogesterone

Estradiol/dydrogesterone (E2/DYD), sold under the brand name Femoston among others, is a combination of estradiol (E2), an estrogen, and dydrogesterone (DYD), a progestin, which is used in menopausal hormone therapy, specifically to treat and prevent hot flashes and osteoporosis, in postmenopausal women.[2][3][4] It is taken by mouth and contains 0.5, 1, or 2 mg E2 and 2.5, 5, 10, or 20 mg DYD per tablet.[5][6][7][8] The medication is marketed widely throughout the world.[5] It is not available in the United States or Canada.[5]

Estradiol/dydrogesterone
Estradiol
Dydrogesterone
Combination of
EstradiolEstrogen
DydrogesteroneProgestogen; Progestin
Clinical data
Trade namesFemoston, Climaston, Femaston
Other namesE2/DYD
Routes of
administration		By mouth
Drug classEstrogen; Progestin; Progestogen
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only) [1]
  • US: ℞-only
Identifiers
CAS Number

See also

References
  1. "Femoston 1/10 mg Film-coated Tablets - Summary of Product Characteristics (SmPC)". (emc). 23 November 2016. Retrieved 23 August 2020.
  2. https://www.medicines.org.uk/emc/files/pil.1347.pdf
  3. Foster RH, Balfour JA (October 1997). "Estradiol and dydrogesterone. A review of their combined use as hormone replacement therapy in postmenopausal women". Drugs Aging. 11 (4): 309–32. doi:10.2165/00002512-199711040-00006. PMID 9342560. S2CID 1733575.
  4. Stevenson JC, Panay N, Pexman-Fieth C (September 2013). "Oral estradiol and dydrogesterone combination therapy in postmenopausal women: review of efficacy and safety". Maturitas. 76 (1): 10–21. doi:10.1016/j.maturitas.2013.05.018. PMID 23835005.
  5. "Dydrogesterone".
  6. Simon Cartwright; Carolyn Godlee (20 January 2012). Churchill's Pocketbook of General Practice E-Book. Elsevier Health Sciences. pp. 55–. ISBN 978-0-7020-5073-2.
  7. Dr. Narendra Teotia (8 April 2016). Living With the Menopause. Fusion Books. pp. 37–. ISBN 978-93-85975-08-0.
  8. Danielle Mazza (7 January 2011). Women's Health in General Practice. Elsevier Health Sciences. pp. 269–. ISBN 978-0-7295-7871-4.
  • "Estradiol". Drug Information Portal. U.S. National Library of Medicine.
  • "Dydrogesterone". Drug Information Portal. U.S. National Library of Medicine.


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