Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate

Estradiol benzoate/estradiol valerate/hydroxyprogesterone caproate (EB/EV/OHPC), sold under the brand name Sin-Ol, is a combination medication of estradiol benzoate (EB), an estrogen, estradiol valerate (EV), an estrogen, and hydroxyprogesterone caproate (OHPC), a progestin, which was reportedly used as a combined injectable contraceptive in women in the early 1970s.[1] It contained 1 mg EB, 10 mg EV, and 250 mg OHPC in oil solution, was provided in the form of 3 mL ampoules, and was administered by intramuscular injection at regular intervals.[1] The medication was manufactured by the pharmaceutical company Reuffer in Mexico.[1]

Estradiol benzoate /
estradiol valerate /
hydroxyprogesterone caproate
Combination of
Estradiol benzoateEstrogen
Estradiol valerateEstrogen
Hydroxyprogesterone caproateProgestogen
Clinical data
Trade namesSin-Ol
Other namesEB/EV/OHPC
Routes of
administration		Intramuscular injection

See also

References
  1. Rudel HW, Kinel FA (September 1972). "Oral Contraceptives. Human Fertility Studies and Side Effects". In Tausk M (ed.). Pharmacology of the Endocrine System and Related Drugs: Progesterone, Progestational Drugs and Antifertility Agents. Vol. II. Pergamon Press. pp. 385–469. ISBN 978-0080168128. OCLC 278011135.



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