GW-803430

GW-803430 (GW-3430) is a drug used in scientific research and is a selective non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has anxiolytic, antidepressant and anorectic effects.[1][2]

GW-803430
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 6-(4-chlorophenyl)-3-[3-methoxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.230.542
Chemical and physical data
FormulaC25H24ClN3O3S
Molar mass482.00 g·mol−1
3D model (JSmol)
SMILES
  • C5CCCN5CCOc3ccc(cc3OC)-n1cnc2cc(sc2c1=O)-c(cc4)ccc4Cl
InChI
  • InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3
  • Key:MWULMTACIBZPGN-UHFFFAOYSA-N
  (verify)

References
  1. Chaki S, Kanuma K (2007). "Neuropeptide receptors: Novel therapeutic targets for depression and anxiety disorders". Drugs of the Future. 32 (9): 809. doi:10.1358/dof.2007.032.09.1131450.
  2. Gehlert DR, Rasmussen K, Shaw J, Li X, Ardayfio P, Craft L, et al. (May 2009). "Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression". The Journal of Pharmacology and Experimental Therapeutics. 329 (2): 429–38. doi:10.1124/jpet.108.143362. PMID 19182070. S2CID 7770969.


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