Immune thrombocytopenic purpura

Immune thrombocytopenic purpura
Other names: Idiopathic thrombocytopenic purpura, idiopathic immune thrombocytopenia, primary immune thrombocytopenia, idiopathic thrombocytopenic purpura, primary immune thrombocytopenic purpura, autoimmune thrombocytopenic purpura
Petechiae, or small bruise-like markings, may occur in ITP
SpecialtyHematology
SymptomsPurple bruises, small red dots in the skin, bleeding gums[1]
ComplicationsIntracranial bleeding[1]
TypesAcute, chronic[2]
Risk factorsPost infection, autoimmune disease[1]
Diagnostic methodPlatelets < 100 x 109/L, normal WBCs, normal RBCs[1]
Differential diagnosisLeukemia, autoimmune hemolytic anemia, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome[1]
TreatmentNone, medications, surgery to remove the spleen[1]
Frequency3 per 100,000 new cases per year[1]

Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura, is low platelets with generally normal white blood cells and red blood cells.[1] Symptoms may include bleeding into the skin, resulting in purpura (purple bruises) or petechiae (small red dots) or bleeding gums.[1] Less commonly more seriously bleeding, such as intracranial bleeding, may occur.[1]

The underlying mechanism typically involves autoantibodies against platelet membrane proteins.[1] This is typically triggered by an infection such as hepatitis C, cytomegalovirus, or varicella zoster, an autoimmune disease such as lupus, a cancer such as chronic lymphocytic leukemia or lymphoma, or certain medications.[1][2] Diagnosis is by finding a platelet level of less than 100 x 109/L (100,000/mm3).[1] Sometimes the remaining platelets may be abnormally large.[1] A bone marrow biopsy is generally not needed.[1]

In adults with platelets of more than 30 x 109/L and children at all platelet levels, who have only mild bleeding, careful observation is generally all that is required.[1] Up to 70% of children will get better within six months.[1] For more significant cases corticosteroids, intravenous immunoglobulin, or anti-D immunoglobulin may be used.[1] In those who do not respond to these treatments eltrombopag or romiplostim may be used.[1] Surgery to remove the spleen may also occasionally be required.[1]

About 3 per 100,000 people are newly affected a year.[1] Rates are similar in children and adults.[1] The acute form more commonly occurs in children while the chronic form more commonly occurs in adults.[2] In earliest description of a case that fits with ITP is from 1025 by Avicenna.[3]

Signs and symptoms

Signs include the spontaneous formation of bruises (purpura) and petechiae (tiny bruises), especially on the extremities, bleeding from the nostrils and/or gums, and menorrhagia (excessive menstrual bleeding), any of which may occur if the platelet count is below 20,000 per μl.[4] A very low count (<10,000 per μl) may result in the spontaneous formation of hematomas (blood masses) in the mouth or on other mucous membranes. Bleeding time from minor lacerations or abrasions is usually prolonged.

Serious and possibly fatal complications due to extremely low counts (<5,000 per μl) include subarachnoid or intracerebral hemorrhage (bleeding inside the skull or brain), lower gastrointestinal bleeding or other internal bleeding. An person with ITP with an extremely low count is vulnerable to internal bleeding caused by blunt abdominal trauma, as might be experienced in a motor vehicle crash. These complications are not likely when the platelet count is above 20,000 per μl.

Pathogenesis

In approximately 60 percent of cases, antibodies against platelets can be detected.[5] Most often these antibodies are against platelet membrane glycoproteins IIb-IIIa or Ib-IX, and are of the immunoglobulin G (IgG) type. The Harrington–Hollingsworth experiment established the immune pathogenesis of ITP.[6]

The coating of platelets with IgG renders them susceptible to opsonization and phagocytosis by splenic macrophages, as well by Kupffer cells in the liver. The IgG autoantibodies are also thought to damage megakaryocytes, the precursor cells to platelets, although this is believed to contribute only slightly to the decrease in platelet numbers. Recent research now indicates that impaired production of the glycoprotein hormone thrombopoietin, which is the stimulant for platelet production, may be a contributing factor to the reduction in circulating platelets. This observation has led to the development of a class of ITP-targeted medications referred to as thrombopoietin receptor agonists.

The stimulus for auto-antibody production in ITP is probably abnormal T cell activity.[7][8][9] Preliminary findings suggest that these T cells can be influenced by medications that target B cells, such as rituximab.[10]

Pregnancy

Anti-platelet autoantibodies in a pregnant woman with ITP will attack the person's own platelets and will also cross the placenta and react against fetal platelets. Therefore, ITP is a significant cause of fetal and neonatal immune thrombocytopenia. Approximately 10% of newborns affected by ITP will have platelet counts <50,000/uL and 1% to 2% will have a risk of intracerebral hemorrhage comparable to infants with neonatal alloimmune thrombocytopenia (NAIT).[11][12]

No lab test can reliably predict if neonatal thrombocytopenia will occur. The risk of neonatal thrombocytopenia is increased with:[13]

  • Mothers with a history of splenectomy for ITP
  • Mothers who had a previous infant affected with ITP
  • Gestational (maternal) platelet count less than 100,000/uL

It is recommended that pregnant women with thrombocytopenia or a previous diagnosis of ITP should be tested for serum antiplatelet antibodies. A woman with symptomatic thrombocytopenia and an identifiable antiplatelet antibody should be started on therapy for their ITP which may include steroids or IVIG. Fetal blood analysis to determine the platelet count is not generally performed as ITP-induced thrombocytopenia in the fetus is generally less severe than NAIT. Platelet transfusions may be performed in newborns, depending on the degree of thrombocytopenia. It is recommended that neonates be followed with serial platelet counts for the first few days after birth.[11][13]

Diagnosis

The diagnosis of ITP is a process of exclusion. First, it has to be determined that there are no blood abnormalities other than a low platelet count, and no physical signs other than bleeding. Then, secondary causes (5–10 percent of suspected ITP cases) should be excluded. Such secondary causes include leukemia, medications (e.g., quinine, heparin), lupus erythematosus, cirrhosis, HIV, hepatitis C, congenital causes, antiphospholipid syndrome, von Willebrand factor deficiency, onyalai and others.[4][14] In approximately 2.7 to 5 percent of cases, autoimmune hemolytic anemia and ITP coexist, a condition referred to as Evans syndrome.[15][16]

Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged. In fact, an enlarged spleen should lead to a search for other possible causes for the thrombocytopenia. Bleeding time is usually prolonged in ITP. However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines[17] and a normal bleeding time does not exclude a platelet disorder.[18]

Bone marrow examination may be performed in those over the age of 60 and those who do not respond to treatment, or when the diagnosis is in doubt.[14] On examination of the marrow, an increase in the production of megakaryocytes may be observed and may help in establishing a diagnosis of ITP. An analysis for anti-platelet antibodies is a matter of clinician's preference, as there is disagreement on whether the 80 percent specificity of this test is sufficient to be clinically useful.[14]

Treatment

With rare exceptions, there is usually no need to treat based on platelet counts. Many older recommendations suggested a certain platelet count threshold (usually somewhere below 20.0/µl) as an indication for hospitalization or treatment. Current guidelines recommend treatment only in cases of significant bleeding. Treatment recommendations sometimes differ for adult and pediatric ITP.[19]

Steroids

Initial treatment usually consists of the administration of corticosteroids, a group of medications that suppress the immune system. The dose and mode of administration is determined by platelet count and whether there is active bleeding: in urgent situations, infusions of dexamethasone or methylprednisolone may be used, while oral prednisone or prednisolone may suffice in less severe cases. Once the platelet count has improved, the dose of steroid is gradually reduced while the possibility of relapse is monitored. 60–90 percent will experience a relapse during dose reduction or cessation.[14][20] Long-term steroids are avoided if possible because of potential side-effects that include osteoporosis, diabetes and cataracts.[21]

Anti-D

Another option, suitable for Rh-positive people with functional spleens is intravenous administration of Rho(D) immune globulin [Human; Anti-D]. The mechanism of action of anti-D is not fully understood. However, following administration, anti-D-coated red blood cell complexes saturate Fcγ receptor sites on macrophages, resulting in preferential destruction of red blood cells (RBCs), therefore sparing antibody-coated platelets. There are two anti-D products indicated for use in ITP: WinRho SDF and Rhophylac. The most common adverse reactions are headache (15%), nausea/vomiting (12%) chills (<2%) and fever (1%).

Steroid-sparing agents

There is increasing use of immunosuppressants such as mycophenolate mofetil and azathioprine because of their effectiveness. In chronic refractory cases, where immune pathogenesis has been confirmed,[22] the off-label use of the vinca alkaloid[23][24][25] and chemotherapy agent vincristine may be attempted.[26][27] However, vincristine has significant side effects[28] and its use in treating ITP must be approached with caution, especially in children.

Intravenous immunoglobulin

Intravenous immunoglobulin (IVIg) may be infused in some cases in order to decrease the rate at which macrophages consume antibody-tagged platelets. However, while sometimes effective, it is costly and produces improvement that generally lasts less than a month. Nevertheless, in the case of people with ITP already scheduled for surgery who has a dangerously low platelet count and has experienced a poor response to other treatments, IVIg can rapidly increase platelet counts, and can also help reduce the risk of major bleeding by transiently increasing platelet counts.

Thrombopoietin receptor agonists

Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. In this, they differ from the previously discussed agents that act by attempting to curtail platelet destruction.[29] Two such products are currently available:

  • Romiplostim (trade name Nplate) is a thrombopoiesis stimulating Fc-peptide fusion protein (peptibody) that is administered by subcutaneous injection. Designated an orphan drug in 2003 under United States law, clinical trials demonstrated romiplostim to be effective in treating chronic ITP, especially in relapsed post-splenectomy.[30][31] Romiplostim was approved by the United States Food and Drug Administration (FDA) for long-term treatment of adult chronic ITP on August 22, 2008.[32]
  • Eltrombopag (trade name Promacta in the USA, Revolade in the EU) is an orally-administered agent with an effect similar to that of romiplostim. It too has been demonstrated to increase platelet counts and decrease bleeding in a dose-dependent manner.[33] Developed by GlaxoSmithKline and also designated an orphan drug by the FDA, Promacta was approved by the FDA on November 20, 2008.[34]

Thrombopoietin receptor agonists exhibited the greatest success so far in treating people with refractory ITP.[35]

Side effects of thrombopoietin receptor agonists include headache, joint or muscle pain, dizziness, nausea or vomiting, and an increased risk of blood clots.[29]

Surgery

Splenectomy (removal of the spleen) may be considered in people who are either unresponsive to steroid treatment, have frequent relapses, or cannot be tapered off steroids after a few months. Platelets which have been bound by antibodies are taken up by macrophages in the spleen (which have Fc receptors), and so removal of the spleen reduces platelet destruction. The procedure is potentially risky in ITP cases due to the increased possibility of significant bleeding during surgery. Durable remission following splenectomy is achieved in 60 - 80 percent of ITP cases.[36] Even though there is a consensus regarding the short-term efficacy of splenectomy, findings on its long-term efficacy and side-effects are controversial.[35][37] After splenectomy, 11.6 - 75 percent of ITP cases relapsed, and 8.7 - 40 percent of ITP cases had no response to splenectomy.[35][38][39][40] The use of splenectomy to treat ITP has diminished since the development of steroid therapy and other pharmaceutical remedies.[41]

Platelet transfusion

Platelet transfusion alone is normally not recommended except in an emergency, and is usually unsuccessful in producing a long-term platelet count increase. This is because the underlying autoimmune mechanism that is destroying the person's platelets will also destroy donor platelets, and so platelet transfusions are not considered a long-term treatment option.

H. pylori eradication

In adults, particularly those living in areas with a high prevalence of Helicobacter pylori (which normally inhabits the stomach wall and has been associated with peptic ulcers), identification and treatment of this infection has been shown to improve platelet counts in a third of people. In a fifth, the platelet count normalized completely; this response rate is similar to that found in treatment with rituximab, which is more expensive and less safe.[42] In children, this approach is not supported by evidence, except in high prevalence areas. Urea breath testing and stool antigen testing perform better than serology-based tests; moreover, serology may be false-positive after treatment with IVIG.[43]

Other agents

  • Dapsone (also called diphenylsulfone, DDS, or avlosulfon) is an anti-infective sulfone medication. Dapsone may also be helpful in treating lupus, rheumatoid arthritis, and as a second-line treatment for ITP. The mechanism by which dapsone assists in ITP is unclear but an increased platelet count is seen in 40–60 percent of recipients.[44][45]
  • The off-label use of rituximab, a chimeric monoclonal antibody against the B cell surface antigen CD20, may sometimes be an effective alternative to splenectomy. However, significant side-effects can occur, and randomized controlled trials are inconclusive.[46]

Prognosis

It is uncommon for people with ITP to present with severe bleeding (only 5% of affected people). However, within five years of diagnosis, 15% of affected individuals are hospitalized with bleeding complications.

Epidemiology

A normal platelet count is considered to be in the range of 150,000–450,000 per microlitre (μl) of blood for most healthy individuals. Hence one may be considered thrombocytopenic below that range, although the threshold for a diagnosis of ITP is not tied to any specific number.

The incidence of ITP is estimated at 50–100 new cases per million per year, with children accounting for half of that amount. At least 70 percent of childhood cases will end up in remission within six months, even without treatment.[47][48][49] Moreover, a third of the remaining chronic cases will usually remit during follow-up observation, and another third will end up with only mild thrombocytopenia (defined as a platelet count above 50,000).[47] A number of immune related genes and polymorphisms have been identified as influencing predisposition to ITP, with FCGR3a-V158 allele and KIRDS2/DL2 increasing susceptibility and KIR2DS5 shown to be protective.[50][51]

ITP is usually chronic in adults[52] and the probability of durable remission is 20–40 percent.[20] The male to female ratio in the adult group varies from 1:1.2 to 1.7 in most age ranges (childhood cases are roughly equal for both genders) and the median age of adults at the diagnosis is 56–60.[14] The ratio between male and female adult cases tends to widen with age. In the United States, the adult chronic population is thought to be approximately 60,000—with women outnumbering men approximately 2 to 1, which has resulted in ITP being designated an orphan disease.[53]

The mortality rate due to chronic ITP varies but tends to be higher relative to the general population for any age range. In a study conducted in Great Britain, it was noted that ITP causes an approximately 60 percent higher rate of mortality compared to gender- and age-matched subjects without ITP. This increased risk of death with ITP is largely concentrated in the middle-aged and elderly. Ninety-six percent of reported ITP-related deaths were individuals 45 years or older. No significant difference was noted in the rate of survival between males and females.[54]

History

After initial reports by the Portuguese physician Amato Lusitano in 1556 and Lazarus de la Rivière (physician to the King of France) in 1658, it was the German physician and poet Paul Gottlieb Werlhof who in 1735 wrote the most complete initial report of the purpura of ITP. Platelets were unknown at the time.[3] The name "Werlhof's disease" was used more widely before the current descriptive name became more popular.[3][55] Platelets were described in the early 19th century, and in the 1880s several investigators linked the purpura with abnormalities in the platelet count.[3][56] The first report of a successful therapy for ITP was in 1916, when a young Polish medical student, Paul Kaznelson, described a female's response to a splenectomy.[3] Splenectomy remained a first-line remedy until the introduction of steroid therapy in the 1950s.[3]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 Pietras, NM; Pearson-Shaver, AL (January 2020). "Immune Thrombocytopenic Purpura". PMID 32965953. {{cite journal}}: Cite journal requires |journal= (help)
  2. 1 2 3 Justiz Vaillant, AA; Gupta, N (January 2020). "ITP-Immune Thrombocytopenic Purpura". PMID 30725925. {{cite journal}}: Cite journal requires |journal= (help)
  3. 1 2 3 4 5 6 Stasi R, Newland AC (May 2011). "ITP: a historical perspective". Br. J. Haematol. 153 (4): 437–50. doi:10.1111/j.1365-2141.2010.08562.x. PMID 21466538.
  4. 1 2 Cines DB, McMillan R (2005). "Management of adult idiopathic thrombocytopenic purpura". Annu. Rev. Med. 56: 425–42. doi:10.1146/annurev.med.56.082103.104644. PMID 15660520.
  5. Coopamah M, Garvey M, Freedman J, Semple J (2003). "Cellular immune mechanisms in autoimmune thrombocytopenic purpura: An update". Transfus Med Rev. 17 (1): 69–80. doi:10.1053/tmrv.2003.50004. PMID 12522773.
  6. Schwartz RS (2007). "Immune thrombocytopenic purpura—from agony to agonist". N. Engl. J. Med. 357 (22): 2299–301. doi:10.1056/NEJMe0707126. PMID 18046034. S2CID 9765360.
  7. Semple JW, Freedman J (1991). "Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia". Blood. 78 (10): 2619–25. doi:10.1182/blood.V78.10.2619.2619. PMID 1840468.
  8. Stasi R, Cooper N, Del Poeta G, et al. (August 2008). "Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab". Blood. 112 (4): 1147–50. doi:10.1182/blood-2007-12-129262. PMID 18375792.
  9. Yu J, Heck S, Patel V, et al. (August 2008). "Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura". Blood. 112 (4): 1325–8. doi:10.1182/blood-2008-01-135335. PMC 2515134. PMID 18420827.
  10. Godeau B, Porcher R, Fain O, et al. (August 2008). "Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter phase 2 study". Blood. 112 (4): 999–1004. doi:10.1182/blood-2008-01-131029. PMID 18463354.
  11. 1 2 Roback et al. AABB Technical Manual, 16th Ed. Bethesda, AABB Press, 2008.
  12. Webert KE, Mittal R, Sigouin C, Heddle NM, Kelton JG (December 2003). "A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura". Blood. 102 (13): 4306–11. doi:10.1182/blood-2002-10-3317. PMID 12947011.
  13. 1 2 Mais DD. ASCP Quick Compendium of Clinical Pathology. Chicago: ASCP Press, 2009.
  14. 1 2 3 4 5 Cines DB, Bussel JB (2005). "How I treat idiopathic thrombocytopenic purpura (ITP)". Blood. 106 (7): 2244–51. doi:10.1182/blood-2004-12-4598. PMID 15941913.
  15. Hansen DL; Möller S; Andersen K; Gaist D; Frederiksen H (2019). "Evans syndrome in adults - incidence, prevalence, and survival in a nationwide". Am J Hematol. 94 (10): 1081–1090. doi:10.1002/ajh.25574. PMID 31292991. S2CID 195879785. Archived from the original on 2021-08-28. Retrieved 2019-10-23.
  16. Michel M; Chanet V; Dechartres A; Morin A-S; Piette J-C; Cirasino L; Emilia G; Zaja F; Ruggeri M; Andrès E; Bierling P; Godeau B; Rodeghiero F (2009). "The spectrum of Evans syndrome in adults: new insight into the disease based on the analysis of 68 cases". Blood. 114 (15): 3167–3172. doi:10.1182/blood-2009-04-215368. PMID 19638626.
  17. "Diagnosis and treatment of idiopathic thrombocytopenic purpura: recommendations of the American Society of Hematology. The American Society of Hematology ITP Practice Guideline Panel". Ann. Intern. Med. 126 (4): 319–26. 1997. doi:10.7326/0003-4819-126-4-199702150-00010. PMID 9036806. S2CID 53089071.
  18. Liesner RJ, Machin SJ (1997). "ABC of clinical haematology. Platelet disorders". BMJ. 314 (7083): 809–12. doi:10.1136/bmj.314.7083.809. PMC 2126215. PMID 9081003.
  19. Neunert C, Lim W, Crowther M, Cohen A, Solberg L, Crowther MA (April 2011). "The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia". Blood. 117 (16): 4190–207. doi:10.1182/blood-2010-08-302984. PMID 21325604.
  20. 1 2 Stevens W, Koene H, Zwaginga JJ, Vreugdenhil G (2006). "Chronic idiopathic thrombocytopenic purpura: present strategy, guidelines and new insights". The Netherlands Journal of Medicine. 64 (10): 356–63. PMID 17122451.
  21. Buchman, AL (Oct 2001). "Side effects of corticosteroid therapy". J Clin Gastroenterol. 33 (4): 289–294. doi:10.1097/00004836-200110000-00006. PMID 11588541. S2CID 23828538.
  22. Psaila, Bethan; Bussel, James B. (2008). "Refractory immune thrombocytopenic purpura: current strategies for investigation and management". British Journal of Haematology. 143 (1): 16–26. doi:10.1111/j.1365-2141.2008.07275.x. PMID 18573111.
  23. van der Heijden, Robert; Jacobs, Denise I.; Snoeijer, Wim; Hallard, Didier; Verpoorte, Robert (2004). "The Catharanthus alkaloids: Pharmacognosy and biotechnology". Current Medicinal Chemistry. 11 (5): 607–628. doi:10.2174/0929867043455846. PMID 15032608.
  24. Raviña, Enrique (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John Wiley & Sons. pp. 157–159. ISBN 9783527326693. Archived from the original on 2019-12-16. Retrieved 2020-05-27.
  25. Cooper, Raymond; Deakin, Jeffrey John (2016). "Africa's gift to the world". Botanical Miracles: Chemistry of Plants That Changed the World. CRC Press. pp. 46–51. ISBN 9781498704304. Archived from the original on 2020-05-21. Retrieved 2020-05-27.
  26. Kuboyama, Takeshi; Yokoshima, Satoshi; Tokuyama, Hidetoshi; Fukuyama, Tohru (2004). "Stereocontrolled total synthesis of (+)-vincristine". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 11966–11970. doi:10.1073/pnas.0401323101. PMC 514417. PMID 15141084.
  27. Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893–5914. doi:10.3390/molecules17055893. PMC 6268133. PMID 22609781.
  28. Ishida, Yoji; Tomiyama, Yoshiaki, eds. (2017). Autoimmune Thrombocytopenia. Springer Nature. ISBN 9789811041426. Archived from the original on 2021-08-28. Retrieved 2020-05-27.
  29. 1 2 "Idiopathic thrombocytopenic purpura: Treatments and Drugs". Mayo Clinic. Archived from the original on November 3, 2012. Retrieved October 16, 2012.
  30. Bussel JB, Kuter DJ, George JN, et al. (2006). "AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP". N. Engl. J. Med. 355 (16): 1672–81. doi:10.1056/NEJMoa054626. PMID 17050891.
  31. Kuter, DJ; Rummel, M; Boccia, R; Macik, BG; Pabinger, I; Selleslag, D; Rodeghiero, F; Chong, BH; Wang, X; Berger, DP (November 2010). "Romiplostim or standard of care in patients with immune thrombocytopenia". N. Engl. J. Med. 363 (20): 1889–99. doi:10.1056/NEJMoa1002625. PMID 21067381. S2CID 22991485.
  32. "Archive copy". Archived from the original on 2008-09-15. Retrieved 2008-08-23.{{cite web}}: CS1 maint: archived copy as title (link)
  33. Bussel JB, Cheng G, Saleh MN, et al. (2007). "Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura". N. Engl. J. Med. 357 (22): 2237–2247. doi:10.1056/NEJMoa073275. PMID 18046028.
  34. "FDA approves Promacta (eltrombopag), the first oral medication to increase platelet production for people with serious blood disorder" (Press release). GlaxoSmithKline. 2008-11-20. Archived from the original on 2010-12-27. Retrieved 2008-11-25.
  35. 1 2 3 Kara-Jovanović, Aleksandar; Suvajdžić-Vuković, Nada (2020-04-30). "Clinical Presentation and Therapy of Primary Immune Thrombocytopenia Resistant to Splenectomy". International Journal of Medical Students. 8 (1): 11–14. doi:10.5195/ijms.2020.436. ISSN 2076-6327. Archived from the original on 2020-05-02. Retrieved 2020-05-16.
  36. Chaturvedi, Shruti; Arnold, Donald M.; McCrae, Keith R. (2018-03-15). "Splenectomy for immune thrombocytopenia: down but not out". Blood. 131 (11): 1172–1182. doi:10.1182/blood-2017-09-742353. ISSN 0006-4971. PMC 5855018. PMID 29295846.
  37. Vianelli, Nicola; Galli, Monica; de Vivo, Antonio; Intermesoli, Tamara; Giannini, Benedetta; Mazzucconi, Maria Gabriella; Barbui, Tiziano; Tura, Sante; Baccaranion, Michele; Gruppo Italiano per lo Studio delle Malattie Ematologiche dell'Adulto (January 2005). "Efficacy and safety of splenectomy in immune thrombocytopenic purpura: long-term results of 402 cases". Haematologica. 90 (1): 72–77. ISSN 1592-8721. PMID 15642672.
  38. McMillan, Robert; Durette, Carol (2004-08-15). "Long-term outcomes in adults with chronic ITP after splenectomy failure". Blood. 104 (4): 956–960. doi:10.1182/blood-2003-11-3908. ISSN 0006-4971. PMID 15100149.
  39. Vianelli, N.; Palandri, F.; Polverelli, N.; Stasi, R.; Joelsson, J.; Johansson, E.; Ruggeri, M.; Zaja, F.; Cantoni, S.; Catucci, A. E.; Candoni, A. (2012-11-09). "Splenectomy as a curative treatment for immune thrombocytopenia: a retrospective analysis of 233 patients with a minimum follow up of 10 years". Haematologica. 98 (6): 875–880. doi:10.3324/haematol.2012.075648. ISSN 0390-6078. PMC 3669442. PMID 23144195.
  40. Ahmed, Rayaz; Devasia, Anup J.; Viswabandya, Auro; Lakshmi, Kavitha M.; Abraham, Aby; Karl, Sampath; Mathai, John; Jacob, Paul M.; Abraham, Deepak; Srivastava, Alok; Mathews, Vikram (2016-07-02). "Long-term outcome following splenectomy for chronic and persistent immune thrombocytopenia (ITP) in adults and children". Annals of Hematology. 95 (9): 1429–1434. doi:10.1007/s00277-016-2738-3. ISSN 0939-5555. PMID 27370992. S2CID 23025470.
  41. Bhatt, NS; Bhatt, P; Donda, K; Dapaah-Siakwan, F; Chaudhari, R; Linga, VG; Patel, B; Lekshminarayanan, A; Bhaskaran, S; Zaid-Kaylani, S; Badawy, SM (September 20, 2018). "Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia". Pediatric Blood & Cancer. 65 (7): e27072. doi:10.1002/pbc.27072. PMID 29637697. S2CID 4778713.
  42. Stasi R, Sarpatwari A, Segal JB, Osborn J, Evangelista ML, Cooper N, Provan D, Newland A, Amadori S, Bussel JB (2009). "Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review". Blood. 113 (6): 1231–40. doi:10.1182/blood-2008-07-167155. PMID 18945961.
  43. Provan D, Stasi R, Newland AC, et al. (2010). "International consensus report on the investigation and management of primary immune thrombocytopenia". Blood. 115 (2): 168–86. doi:10.1182/blood-2009-06-225565. PMID 19846889.
  44. Godeau B, Durand JM, Roudot-Thoraval F, et al. (1997). "Dapsone for chronic autoimmune thrombocytopenic purpura: a report of 66 cases". Br. J. Haematol. 97 (2): 336–9. doi:10.1046/j.1365-2141.1997.412687.x. PMID 9163598.
  45. Wozel, G.; Blasum, C. (2014). "Dapsone in dermatology and beyond". Arch. Dermatol. Res. 306 (2): 103–24. doi:10.1007/s00403-013-1409-7. PMC 3927068. PMID 24310318.
  46. National Institute for Health and Care Excellence. Immune (idiopathic) thrombocytopenic purpura: rituximab. October 2014. Archived 2015-04-14 at the Wayback Machine
  47. 1 2 Watts RG (2004). "Idiopathic thrombocytopenic purpura: a 10-year natural history study at the children's hospital of Alabama". Clinical Pediatrics. 43 (8): 691–702. doi:10.1177/000992280404300802. PMID 15494875. S2CID 43752571.
  48. Treutiger I, Rajantie J, Zeller B, Henter JI, Elinder G, Rosthøj S (2007). "Does treatment of newly diagnosed idiopathic thrombocytopenic purpura reduce morbidity?". Arch. Dis. Child. 92 (8): 704–7. doi:10.1136/adc.2006.098442. PMC 2083887. PMID 17460024.
  49. Ou CY, Hsieh KS, Chiou YH, Chang YH, Ger LP (2006). "A comparative study of initial use of intravenous immunoglobulin and prednisolone treatments in childhood idiopathic thrombocytopenic purpur". Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi. 47 (5): 226–31. PMID 17352309.
  50. Nourse, JP (Jan 2012). "The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms". Blood Coagul. Fibrinolysis. 23 (1): 45–50. doi:10.1097/mbc.0b013e32834d7ce3. PMID 22024796. S2CID 3327902.
  51. Seymour, LA (Mar 2014). "The presence of KIR2DS5 confers protection against adult immune thrombocytopenia". Tissue Antigens. 83 (3): 154–60. doi:10.1111/tan.12295. PMID 24571473.
  52. Cines DB, Blanchette VS (2002). "Immune thrombocytopenic purpura". N. Engl. J. Med. 346 (13): 995–1008. doi:10.1056/NEJMra010501. PMID 11919310.
  53. "Amgen to Discuss Romiplostim BLA". drugs.com. March 12, 2008. Archived from the original on 2016-03-03. Retrieved 2008-11-04.
  54. Schoonen WM, Kucera G, Coalson J, et al. (April 2009). "Epidemiology of immune thrombocytopenic purpura in the General Practice Research Database". Br. J. Haematol. 145 (2): 235–44. doi:10.1111/j.1365-2141.2009.07615.x. PMID 19245432.
  55. synd/3349 at Who Named It?
  56. Liebman HA (2008). "Immune thrombocytopenia (ITP): an historical perspective". Hematology Am Soc Hematol Educ Program. 2008 (1): 205. doi:10.1182/asheducation-2008.1.205. PMID 19074083.
Classification
External resources
This article is issued from Offline. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.