Tobramycin/dexamethasone

Tobramycin/dexamethasone
Combination of
TobramycinAminoglycoside antibiotic
DexamethasoneGlucocorticoid
Names
Trade namesTobradex
Clinical data
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: C (Risk not ruled out)[1]
    Routes of
    use    		Eye drops, topical
    External links
    AHFS/Drugs.comProfessional Drug Facts
    Legal
    Legal status
    Identifiers
    CAS Number
    • 32986-56-4 checkY
    • 50-02-2 checkY
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    ATC code

    Tobramycin/dexamethasone, sold under the brand name Tobradex, is a fixed-dose combination medication in the form of eye drops and eye ointment, marketed by Alcon.[2][3][4] The active ingredients are tobramycin (an antibiotic) and dexamethasone (a corticosteroid).[3] It is prescribed for the treatment of pink eye in combination with bacterial infections.[3]

    Contraindications

    It is contraindicated with herpetic and other viral eye infections. Other contraindications include fungal and mycobacterial infections because tobramycin is inactive against those, and the corticoid acts as an immunosuppressive agent, preventing the body's immune system from dealing with the infection. The drops are also contraindicated in patients with corneal lesions.[5][2][3][4]

    Side effects

    Similarly to other corticosteroid eye drops, side effects include hypersensitivity and, especially after long-term use, secondary eye infections, cataract (clouding of the eye lens) and increased intraocular pressure, leading to glaucoma. Consequently, the drug should not be applied longer than 24 days[5][6][7] without further medical evaluation.[3][4]

    Interactions

    Anticholinergic eye drops potentiate the risk of increased intraocular pressure. Systemic aminoglycoside antibiotics increase toxicity for ears, nerves and kidney.[5]

    Society and culture

    Brand names

    Tobrason is a brand name in Jordan.[8]

    Cost

    The U.S. cost for 2.5 ml ophthalmic suspension 0.1%-0.3% is $42 (USD)[9]


    • DexamethasoneTobramycin costs (US)
      DexamethasoneTobramycin costs (US)
    • DexamethasoneTobramycin prescriptions (US)
      DexamethasoneTobramycin prescriptions (US)

    References

    1. ↑ "Dexamethasone / tobramycin ophthalmic Use During Pregnancy". Drugs.com. 28 November 2018. Archived from the original on 25 November 2020. Retrieved 13 September 2020.
    2. 1 2 3 "Tobradex- tobramycin and dexamethasone ointment". DailyMed. 24 April 2020. Archived from the original on 17 August 2020. Retrieved 24 September 2020.
    3. 1 2 3 4 5 6 "Tobradex- tobramycin and dexamethasone suspension/ drops". DailyMed. 24 April 2020. Archived from the original on 17 August 2020. Retrieved 24 September 2020.
    4. 1 2 3 4 "Tobradex ST- tobramycin / dexamethasone suspension/ drops". DailyMed. 9 September 2019. Archived from the original on 29 October 2020. Retrieved 24 September 2020.
    5. 1 2 3 Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. Tobradex-Augentropfen. ISBN 978-3-85200-196-8.{{cite book}}: CS1 maint: unrecognized language (link)
    6. ↑ Faschinger C (3 January 2011). "TobraDex". Österreichische Apothekerzeitung (in German) (1/2011): 13.{{cite journal}}: CS1 maint: unrecognized language (link)
    7. ↑ Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 2 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.{{cite book}}: CS1 maint: unrecognized language (link)
    8. ↑ "Jordanian Food and Drug Administration". Archived from the original on 2020-11-16. Retrieved 2013-10-24.
    9. ↑ "Dexamethasone/tobramycin ophthalmic Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 24 January 2021. Retrieved 27 March 2021.
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