5-TFMO-DMT

5-TFMO-DMT (5-(trifluoromethoxy)-DMT, 5-OCF3-DMT, 5-(trifluoromethoxy)-N,N-dimethyltryptamine) is a psychedelic tryptamine derivative related to drugs such as 5-MeO-DMT and DMT (DMT). It acts as an agonist at the 5-HT2A receptor with an EC50 of 127.2 nM.[1] It was shown to release serotonin (5-HT) from synaptosomal preparations, and to reduce immobility time in the forced-swim test in animal studies, suggesting that it might have antidepressant activity.[1]

5-(Trifluoromethoxy)-DMT
Clinical data
Other names5-OCF3-DMT
Identifiers
  • N,N-dimethyl-5-(trifluoromethoxy)-1H-Indole-3-ethanamine
CAS Number
PubChem CID
Chemical and physical data
FormulaC13H15F3N2O
Molar mass272.271 g·mol−1
3D model (JSmol)
  • CN(C)CCC1=CNC2=CC=C(OC(F)(F)F)C=C21
  • InChI=InChI=1S/C13H15F3N2O/c1-18(2)6-5-9-8-17-12-4-3-10(7-11(9)12)19-13(14,15)16/h3-4,7-8,17H,5-6H2,1-2H3
  • Key:ODQYGFDOWUZNBA-UHFFFAOYSA-N

See also

References
  1. WO 2022/235927, Kruegel AC, "NOVEL TRYPTAMINES AND METHODS OF TREATING MOOD DISORDERS.", published 10 November 2022, assigned to Gilgamesh Pharmaceuticals, Inc..


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.