LAE-32

D-Lysergic acid ethylamide (LAE-32) is a derivative of ergine.[1][2] It is reported to have some LSD-like effects but is weaker and shorter lasting, with an active dose reported to be between 0.5 and 1.5 milligrams.

LAE-32
Clinical data
Other namesLAE; Lysergic acid ethylamide; d-Lysergic acid ethylamide; d-Ethyllysergamide,
Routes of
administration		Oral
Pharmacokinetic data
MetabolismHepatic
ExcretionRenal
Identifiers
  • (8β)-N-Ethyl-6-methyl-9,10-didehydroergoline-8-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H21N3O
Molar mass295.386 g·mol−1
3D model (JSmol)
  • CCNC(=O)[C@@H]2C=C1c3cccc4[nH]cc(C[C@H]1N(C)C2)c34
  • InChI=1S/C18H21N3O/c1-3-19-18(22)12-7-14-13-5-4-6-15-17(13)11(9-20-15)8-16(14)21(2)10-12/h4-7,9,12,16,20H,3,8,10H2,1-2H3,(H,19,22)/t12-,16-/m1/s1 checkY
  • Key:VEBWTGYUIBTVNR-MLGOLLRUSA-N checkY
  (verify)

It was studied by the CIA as part of Project MKULTRA. Documents published by the CIA under the Freedom of Information Act suggest it causes "a schizophrenia-like condition" but it allows people with schizophrenia to remain indifferent to their disorder.

References
  1. "N-Ethyllysergamide". PubChem. U.S. National Library of Medicine. Retrieved 2022-11-16.
  2. Baquiran M, Al Khalili Y (2022). "Lysergic Acid Diethylamide Toxicity". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 31985997. Retrieved 2022-11-18.


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