60S ribosomal protein L10a

60S ribosomal protein L10a is a protein that in humans is encoded by the RPL10A gene.[5][6][7]

RPL10A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPL10A, CSA19, Csa-19, L10A, NEDD6, ribosomal protein L10a, uL1
External IDsOMIM: 615660 MGI: 1343877 HomoloGene: 68543 GeneCards: RPL10A
Orthologs
SpeciesHumanMouse
Entrez

4736

19896

Ensembl

ENSG00000198755

ENSMUSG00000037805

UniProt

P62906

P53026

RefSeq (mRNA)

NM_007104

NM_011287
NM_001357628

RefSeq (protein)

NP_009035

n/a

Location (UCSC)Chr 6: 35.47 – 35.47 MbChr 17: 28.55 – 28.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene used to be referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000198755 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037805 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fisicaro N, Katerelos M, Williams J, Power D, D'Apice A, Pearse M (Aug 1995). "Identification of genes downregulated in the thymus by cyclosporin-A: preliminary characterization of clone CSA-19". Mol Immunol. 32 (8): 565–72. doi:10.1016/0161-5890(95)00032-A. PMID 7609734.
  6. Tripodis N, Mason R, Humphray SJ, Davies AF, Herberg JA, Trowsdale J, Nizetic D, Senger G, Ragoussis J (Jan 1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
  7. "Entrez Gene: RPL10A ribosomal protein L10a".

Further reading


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