MRPS25

28S ribosomal protein S25, mitochondrial is a protein that in humans is encoded by the MRPS25 gene.[5][6]

MRPS25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPS25, MRP-S25, RPMS25, mitochondrial ribosomal protein S25, COXPD50
External IDsOMIM: 611987 MGI: 1928140 HomoloGene: 11207 GeneCards: MRPS25
Orthologs
SpeciesHumanMouse
Entrez

64432

64658

Ensembl

ENSG00000131368

ENSMUSG00000014551

UniProt

P82663

Q9D125

RefSeq (mRNA)

NM_022497

NM_025578

RefSeq (protein)

NP_071942

NP_079854

Location (UCSC)Chr 3: 15.01 – 15.07 MbChr 6: 92.15 – 92.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000131368 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000014551 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
  6. "Entrez Gene: MRPS25 mitochondrial ribosomal protein S25".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P82663 (28S ribosomal protein S25, mitochondrial) at the PDBe-KB.
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