60S ribosomal protein L15

60S ribosomal protein L15 is a protein that in humans is encoded by the RPL15 gene.[5][6]

RPL15
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPL15, DBA12, EC45, L15, RPL10, RPLY10, RPYL10, ribosomal protein L15
External IDsOMIM: 604174 MGI: 1913730 HomoloGene: 37713 GeneCards: RPL15
Orthologs
SpeciesHumanMouse
Entrez

6138

66480

Ensembl

ENSG00000174748

ENSMUSG00000012405

UniProt

P61313

Q9CZM2

RefSeq (mRNA)

NM_025586
NM_001359897
NM_001359899

RefSeq (protein)

NP_079862
NP_001346826
NP_001346828

Location (UCSC)Chr 3: 23.92 – 23.92 MbChr 14: 4.2 – 4.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000174748 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000012405 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  6. "Entrez Gene: RPL15 ribosomal protein L15".

Further reading


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