Mitochondrial ribosomal protein L17

39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.[5]

MRPL17
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL17, L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, mitochondrial ribosomal protein L17
External IDsOMIM: 611830 MGI: 1351608 HomoloGene: 32526 GeneCards: MRPL17
Orthologs
SpeciesHumanMouse
Entrez

63875

27397

Ensembl

ENSG00000158042

ENSMUSG00000030879

UniProt

Q9NRX2

Q9D8P4

RefSeq (mRNA)

NM_022061

NM_025301

RefSeq (protein)

NP_071344

NP_079577

Location (UCSC)Chr 11: 6.68 – 6.68 MbChr 7: 105.45 – 105.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000158042 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030879 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: MRPL17 mitochondrial ribosomal protein L17".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9NRX2 (39S ribosomal protein L17, mitochondrial) at the PDBe-KB.
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